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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
lupus syndrome
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "lupus syndrome" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-18620
CAS No.: 33231-14-0
Research Areas:
DZ2002 is an orally active, reversible and low-cytotoxic type III SAHH inhibitor (Ki=17.9 nM), with good immunosuppressive activity. DZ2002 prevents the development of experimental dermal fibrosis by reversing the profibrotic phenotype of various cell types. DZ2002 can be used in studies of autoimmune diseases such as lupus syndrome and systemic sclerosis .
Cat. No.: HY-P99625
CAS No.: 2515463-86-0
Synonyms: SAR441344; INX-021
Target:
Research Areas:
Cat. No.: HY-P4155
Target:
Research Areas:
Cat. No.: HY-18620R
CAS No.: 33231-14-0
Research Areas:
DZ2002 (Standard) is the analytical standard of DZ2002. This product is intended for research and analytical applications. DZ2002 is an orally active, reversible and low-cytotoxic type III SAHH inhibitor (Ki=17.9 nM), with good immunosuppressive activity. DZ2002 prevents the development of experimental dermal fibrosis by reversing the profibrotic phenotype of various cell types. DZ2002 can be used in studies of autoimmune diseases such as lupus syndrome and systemic sclerosis .
Cat. No.: HY-185893
CAS No.: 3126213-85-9
Target:
Research Areas:
UNC11676A is an MDA5 ATPase inhibitor with IC50 values of 6 μM, 115 μM and 108 μM against MDA5, LGP2 and DDX1, respectively. MDA5, LGP2 and DDX1 are three human DExD/H-box RNA helicases. UNC11676A can be used in the research of Aicardi-Goutières syndrome, Singleton-Merten syndrome, systemic lupus erythematosus and Alzheimer's disease .
Cat. No.: HY-178049A
Target:
Research Areas:
UM-259 hydrochloride is a STING inhibitor with activity against both murine and human STING (including the STING R232 mutant). UM-259 hydrochloride inhibits STING-dependent signaling pathways, blocks STING oligomerization, and acts on human primary CD14 + monocytes. UM-259 hydrochloride can be used for research on amyotrophic lateral sclerosis, lupus erythematosus, Aicardi-Goutières syndrome, and infant-onset STING-associated vasculopathy .
Cat. No.: HY-P73630A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SSB; Sjoegren syndrome Type B Antigen; Small RNA Binding Exonuclease Protection Factor La; Sjogren syndrome Antigen B; lupus La Protein; La Ribonucleoprotein; La Autoantigen; SS-B; La/SSB; Sjogren syndrome Antigen B (Autoantigen La); LARP3; lupus La Antig
Species:
Human
Source:
E. coli
Cat. No.: HY-P73630
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SSB; Sjoegren syndrome Type B Antigen; Small RNA Binding Exonuclease Protection Factor La; Sjogren syndrome Antigen B; lupus La Protein; La Ribonucleoprotein; La Autoantigen; SS-B; La/SSB; Sjogren syndrome Antigen B (Autoantigen La); LARP3; lupus La Antig
Species:
Human
Source:
E. coli
Cat. No.: HY-P73629
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SSB; Sjoegren syndrome Type B Antigen; Small RNA Binding Exonuclease Protection Factor La; Sjogren syndrome Antigen B; lupus La Protein; La Ribonucleoprotein; La Autoantigen; SS-B; La/SSB; Sjogren syndrome Antigen B (Autoantigen La); LARP3; lupus La Antig
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-184075S
CAS No.: 2794195-73-4
Cat. No.: HY-P78939
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SSB; Sjoegren syndrome Type B Antigen; Small RNA Binding Exonuclease Protection Factor La; Sjogren syndrome Antigen B; lupus La Protein; La Ribonucleoprotein; La Autoantigen; SS-B; La/SSB; Sjogren syndrome Antigen B (Autoantigen La); LARP3; lupus La Antigen; La; SS-B/La Protein; La Ribonucleoprotein Domain Family, Member 3; Autoantigen La
Species:
Others
Source:
E. coli
Cat. No.: HY-184593
Target:
Research Areas:
UM-232 is a highly selective covalent STING antagonist with an EC50 of 6.20 μM in STING R232-expressing THP-1 cells. UM-232 covalently targets C292 and C309 cysteines of STING, blocks STING oligomerization and inhibits downstream TBK1/IRF3 activation and proinflammatory cytokine transcription. UM-232 has low off-target reactivity and good hepatic stability, serving as a chemical probe for STING-driven autoimmune and inflammatory diseases including Aicardi-Goutières syndrome (AGS), Systemic Lupus Erythematosus (SLE) and Amyotrophic Lateral Sclerosis (ALS) .
Research Areas:
Oxophenarsine hydrochloride is an anti-syphilitic agent, and also has non-classical applications including treating chronic discoid lupus erythematosus, inhibiting HIV-1 protein synthesis, and prolonging the duration of insulin action . Oxophenarsine hydrochloride forms an unstable insulin complex via sulfhydryl groups or free amino groups, thereby prolonging the hypoglycemic effect of insulin. Oxophenarsine hydrochloride inhibits HIV-1-specific protein synthesis and virus production .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
