SSB Protein, Human (His)
The SSB protein critically binds to the 3' poly(U) terminus of RNA polymerase III transcripts, preventing exonuclease digestion and aiding in correct folding. In coxsackievirus B3 infection, SSB binds to the viral internal ribosome entry site (IRES) and enhances IRES-mediated translation. SSB Protein, Human (His) is the recombinant human-derived SSB protein, expressed by E. coli , with N-His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
The SSB protein critically binds to the 3' poly(U) terminus of RNA polymerase III transcripts, preventing exonuclease digestion and aiding in correct folding. In coxsackievirus B3 infection, SSB binds to the viral internal ribosome entry site (IRES) and enhances IRES-mediated translation. SSB Protein, Human (His) is the recombinant human-derived SSB protein, expressed by E. coli , with N-His labeled tag.
The SSB protein plays a crucial role by binding to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, providing protection against exonuclease digestion and facilitating their proper folding and maturation, as evidenced by various studies. Additionally, in the context of Coxsackievirus B3 infection, SSB binds to the viral internal ribosome entry site (IRES), thereby stimulating IRES-mediated translation. The protein further engages in interactions with DDX15 and may potentially interact with RUFY1, indicating its involvement in diverse cellular processes and highlighting its multifunctional nature.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-His
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Accession
P05455 (M1-Q408)
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Molecular Construction
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N-term
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His
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SSB (M1-Q408)
Accession # P05455 -
C-term
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Protein Length
Full Length
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Synonyms
SSB; Sjoegren Syndrome Type B Antigen; Small RNA Binding Exonuclease Protection Factor La; Sjogren Syndrome Antigen B; Lupus La Protein; La Ribonucleoprotein; La Autoantigen; SS-B; La/SSB; Sjogren Syndrome Antigen B (Autoantigen La); LARP3; Lupus La Antig
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AA Sequence
MAENGDNEKMAALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRRSPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLLILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEGIILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKKTKFASDDEHDEHDENGATGPVKRAREETDKEEPASKQQKTENGAGDQ
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Predicted Molecular Mass
47.8 kDa
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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