SSB - small RNA binding exonuclease protection factor La Gene

Also Known as La; LARP3; La/SSB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6741

About SSB

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:169,798,871-169,812,064 (from NCBI)

This gene has 12 transcripts (splice variants), 219 orthologues and 6 paralogues. Ubiquitous expression in fat (RPKM 51.7), thyroid (RPKM 36.0) and 25 other tissues.

Summary

The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]

SSB Products (2)

mRNA	Protein	Name
NM_001294145.2	NP_001281074.1	lupus La protein
NM_003142.5	NP_003133.1	lupus La protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IMP IMP: Inferred from mutant phenotype	3192525	GOA
enables poly(U) RNA binding	IMP IMP: Inferred from mutant phenotype	12842046	GOA
enables poly(U) RNA binding	IPI IPI: Inferred from physical interaction	12842046	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23552417	GOA
enables sequence-specific mRNA binding	IMP IMP: Inferred from mutant phenotype	9154801	GOA
enables tRNA binding	IMP IMP: Inferred from mutant phenotype	10983981	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in IRES-dependent viral translational initiation	IDA IDA: Inferred from direct assay	12384597	GOA
involved in nuclear histone mRNA catabolic process	IMP IMP: Inferred from mutant phenotype	9154801	GOA
involved in protein localization to cytoplasmic stress granule	IDA IDA: Inferred from direct assay	24965446	GOA
involved in tRNA 3'-end processing	IGI IGI: Inferred from genetic interaction	10983981	GOA
involved in tRNA 5'-leader removal	IGI IGI: Inferred from genetic interaction	10983981	GOA
involved in tRNA export from nucleus	IMP IMP: Inferred from mutant phenotype	17308035	GOA
involved in tRNA processing	IMP IMP: Inferred from mutant phenotype	17308035	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17308035	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17308035	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SSB Protein Structure

RRM_1

RRM_3

0
100
200
300
408 a.a.

Protein Preferred Names	Protein Names
lupus La protein	La ribonucleoprotein domain family, member 3

SSB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SSB	P05455	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	SSB	P05455	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	SSB	P05455	HTT	Homo sapiens	P42858	Y2H Array	32814053
Cross	SSB	P05455	Q99IB8-PRO_0000045599	Hepatitis C virus	Q99IB8-PRO_0000045599	Anti Bait CoIP	23552417
Cross	SSB	P05455	Q99IB8-PRO_0000045603	Hepatitis C virus	Q99IB8-PRO_0000045603	Anti Bait CoIP	23552417

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SSB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73629	SSB Protein, Human (sf9, His)	P05455 (M1-Q408)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73630	SSB Protein, Human (His)	P05455 (M1-Q408)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73630A	SSB Protein, Human	P05455 (M1-Q408)	≥ 95%, as determined by reducing SDS-PAGE.

SSB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80901	SSB Antibody (YA668)	WB	Human
HY-P80901A	SSB Antibody (YA668)(PBS only)	WB	Human

Related Diseases

Diseases	Alias
Sjogren Syndrome	Sicca Syndrome Sjogren'S Syndrome Sjögren Syndrome Sjogren-Gougerot Syndrome Keratoconjunctivitis Sicca Sjögren'S Syndrome Xerodermosteosis Dacryosialoadenopathia Atrophicans Gougerot-Houwer-Sjogren Syndrome Gougerot-Sjogren Syndrome Keratoconjunctivitis Sicca-Xerostomia Secreto-Inhibitor-Xerodermostenosis Primary Sjogren Syndrome Primary Sjogren-Gougerot Syndrome Sjogrens Syndrome Primary Sjogrens Syndrome Dry Eye Syndromes
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Heart Block, Congenital	Congenital Heart Block Heart Block Congenital Congenital Atrioventricular Block
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Xerophthalmia	Conjunctival Xerosis
Second-Degree Atrioventricular Block	Second-Degree Heart Block Second Degree Atrioventricular Block Second Degree Atrioventricular Heart Block Second Degree Heart Block Incomplete Atrioventricular Block, Second Degree Nos Second-Degree Block, Type 1 And 2 Atrioventricular Block, Type 1 And 2 Second Degree Incomplete Atrioventricular Block Av - [Atrioventricular] Block 2nd
Autoimmune Disease Of Exocrine System
Lacrimal Apparatus Disease	Lacrimal Apparatus Diseases
Hepatitis C Virus	Hepatitis C Virus, Susceptibility To Hepatitis C Virus Infection, Response To Therapy Of Hcv Hcv, Susceptibility To Hepatitis C Virus, Resistance To Hepatitis C Virus, Response To Therapy Of Resistance To Hepatitis C Virus
Parotid Disease	Parotid Diseases
Potocki-Shaffer Syndrome	Proximal 11p Deletion Syndrome Chromosome 11p11.2 Deletion Syndrome Pss 11p11.2 Deletion P11pds Defect11 Syndrome Deletion Of Chromosome 11p11.2 POSHS
Diffuse Infiltrative Lymphocytosis Syndrome
Mononeuritis Multiplex
Cutaneous Lupus Erythematosus	Lupus Erythematosus, Cutaneous Lupus Erythematosus Cutaneous
Mononeuritis Of Upper Limb And Mononeuritis Multiplex
Keratoconjunctivitis Sicca	Kcs Dry Eye Syndromes Keratitis Sicca Xerophthalmia
Dry Eye Syndrome	Dry Eye Syndromes Dry Eye Disease Tear Film Insufficiency Xerophthalmia
Third-Degree Atrioventricular Block	Third Degree Atrioventricular Block Complete Atrioventricular Block Complete Av Block Third-Degree Block Complete Atrioventricular Heart Block Complete Heart Block Third Degree Atrioventricular Heart Block Third Degree Heart Block Complete Heart Block Nos Chb - [Complete Heart Block] Idioventricular Rhythm Av - [Atrioventricular] Block, Complete
Endocardial Fibroelastosis	Endomyocardial Fibroelastosis Elastomyofibrosis EFE Efe - [Endocardial Fibroelastosis] Primary Endocardial Fibroelastosis Fibroelastosis Cordis Fetal Endocarditis Fibroelastosis Congenital Endocardial Fibroelastosis Congenital Valvular Endocarditis
Chromosomal Deletion Syndrome
Dacryoadenitis	Dacryocystitis
Lymphoid Interstitial Pneumonia	Lymphocytic Interstitial Pneumonia Lip Disease Lip Diseases LIP Disease Of Lips
Systemic Scleroderma	Scleroderma Progressive Systemic Sclerosis Systemic Sclerosis Scleroderma, Systemic Scleroderma Syndrome Dermatosclerosis Familial Progressive Scleroderma Progressive Scleroderma Scleroderma Disease Scleroderma, Localized Diffuse Scleroderma Scleroderma, Familial Progressive
Atrioventricular Block	Av Block
Drug-Induced Lupus Erythematosus	Dile Dil Drug-Induced Systemic Lupus Erythematosus
Munchausen By Proxy	Munchausen Syndrome By Proxy Munchausen By Proxy Syndrome Münchausen Syndrome By Proxy
Sialadenitis	Sialoadenitis Adenitis, Salivary Gland Salivary Gland Inflammation Salivary Gland Adenitis Sialitis Inflammation Of Salivary Gland Inflammation Of Salivary Duct Or Gland Salivary Glandular Adenitis Sialoangiitis Sialoangitis Sialodochitis
Mononeuropathy	Mononeuropathies
Parotitis
Mikulicz Disease	Igg4-Related Dacryoadenitis And Sialadenitis Mikulicz'S Disease Chronic Dacryoadenitis And Sialadenitis Mikulicz Syndrome Mikulicz' Disease
Chronic Interstitial Cystitis
Salivary Gland Disease	Salivary Gland Disorders Salivary Gland Diseases Non-Neoplastic Salivary Gland Disease Non-Neoplastic Salivary Gland Disorder Disorder Of Salivary Gland Lesion Of Salivary Gland Nos
Aphthous Stomatitis	Oral Ulcer Canker Sore Aphtha Aphthous Ulceration Oral Aphthae Oral Aphthous Ulcer Canker Sores Stomatitis, Aphthous Minor Oral Aphthous Ulceration
Chromosomal Disease	Chromosomal Disorders Congenital Chromosomal Disease
Limited Scleroderma	Limited Cutaneous Systemic Sclerosis Limited Systemic Sclerosis Systemic Sclerosis Sine Scleroderma Crest Syndrome Limited Cutaneous Systemic Scleroderma Scleroderma, Limited Systemic Sclerosis, Limited Progressive Systemic Sclerosis Sine Scleroderma Scleroderma, Sine Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10617A	Rucaparib	Inhibitor	99.96%	Yes
HY-10617	Rucaparib phosphate	Inhibitor	99.76%	Yes
HY-102003	Rucaparib monocamsylate	Inhibitor	99.91%	Yes
HY-102003A	Rucaparib camsylate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145804	Palacaparib	Inhibitor	98.30%	Phase 2

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137457	Venadaparib	Inhibitor	98.11%	Unkown
HY-122891A	(2S)-SB02024	Inhibitor	98.14%	Unkown
HY-105510	Hydroxyrubicin		/	Unkown
HY-10617AS1	Rucaparib-d3	Inhibitor	/	Unkown
HY-132267S	N-Nitrosodibenzylamine-d4	Inhibitor	/	Unkown
HY-172154	SSB-2548		/	Unkown
HY-RS13804	SSB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W703958	N-Nitrosodibenzylamine-d10		/	Unkown
HY-RS17122	Ssb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23567	Ssb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W159870	N-Nitrosodibenzylamine	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SSB	VGNC	VGNC:58552
Bos taurus	SSB	VGNC	VGNC:58554
Rattus norvegicus	SSB	RGD	RGD:620804
Felis catus	SSB	VGNC	VGNC:65699
Mus musculus	SSB	MGD	MGI:98423
Others	SSB	NCBI