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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
mammalian DNA polymerase α
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "mammalian DNA polymerase α" in MCE Product Catalog:
Cat. No.: HY-N16549
CAS No.: 86631-41-6
Synonyms: 3-O-Galloylprocyanidin B3
Cat. No.: HY-106787
CAS No.: 105128-93-6
Target:
Research Areas:
HO 221 is an orally active benzoylphenylurea derivative with antitumor activity. HO 221 can inhibit the activity of mammalian DNA polymerase alpha. HO 221 can induce G1 phase arrest. HO 221 can be used for the research of cancer, such as leukemia .
Cat. No.: HY-186293
CAS No.: 662144-62-9
Research Areas:
3-Lauroylcatechin is a DPPH free radical scavenger. 3-Lauroylcatechin inhibits the activities of mammalian DNA polymerase α and β. 3-Lauroylcatechin can be used in studies related to colon cancer .
Cat. No.: HY-119787
CAS No.: 27267-69-2
Synonyms: Collinomycin
Cat. No.: HY-185899
CAS No.: 72052-96-1
Synonyms: 5-Aza-2'-deoxycytidine-5′-triphosphate
5-Aza-dCTP (5-Aza-2'-deoxycytidine-5′-triphosphate) is a nucleotide analog that acts as a substrate for mammalian DNA polymerase α (Km = 3.0 μM) and a weak competitive inhibitor of this enzyme (Ki = 4.3 μM). 5-Aza-dCTP inhibits DNA polymerase α via incorporation into DNA through Watson-Crick base pairing, inhibits DNA methyltransferases via incorporation into hemimethylated DNA, and induces mutations in HIV-1 via incorporation into viral DNA during synthesis. 5-Aza-dCTP reverses the inhibitory effect of dTTP on dCMP deaminase, and allosterically activates dCMP deamination to the same extent as dCTP. 5-Aza-dCTP is applicable to research related to leukemia and type 1 human immunodeficiency virus infection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
