27267-69-2
Chemical Structure
α-Rubromycin
Synonym(s): Collinomycin
- CAS No.: 27267-69-2
- Formula:C27H20O12
- Molecular Weight:536.44
IUPAC Name: methyl 7,8-dihydroxy-6-(2-(8-hydroxy-5,7-dimethoxy-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-yl)ethyl)-1-oxo-1H-isochromene-3-carboxylate
InChIKey: LQNGOIZVRFNQLO-UHFFFAOYSA-N
SMILES: O=C(OC)C1=CC2=CC(CCC3=CC(C(C4=C5C(O)=C(C=C4OC)OC)=O)=C(O3)C5=O)=C(C(O)=C2C(O1)=O)O
Biological Activity: α-Rubromycin (Collinomycin) is an antibiotic isolated from the mycelia of Streptomyces collinus. α-Rubromycin also acts as a DNA polymerase inhibitor, with an IC50 of 0.91 μM against bovine mammalian DNA polymerase. α-Rubromycin binds to the active region of DNA polymerase β, competes with nucleotide substrates for binding, and interferes with template-DNA interactions. α-Rubromycin inhibits the activities of telomerase, retroviral reverse transcriptase and terminal deoxynucleotidyl transferase, as well as the growth of Staphylococcus aureus. α-Rubromycin can be used in studies related to bacterial infections[1][2].
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α-Rubromycin | α-Rubromycin (Collinomycin) is an antibiotic isolated from the mycelia of Streptomyces collinus. α-Rubromycin also acts as a DNA polymerase inhibitor, with an IC50 of 0.91 μM against bovine mammalian DNA polymerase. α-Rubromycin binds to the active region of DNA polymerase β, competes with nucleotide substrates for binding, and interferes with template-DNA interactions. α-Rubromycin inhibits the activities of telomerase, retroviral reverse transcriptase and terminal deoxynucleotidyl transferase, as well as the growth of Staphylococcus aureus. α-Rubromycin can be used in studies related to bacterial infections. | |||||||||||||||||||||
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References
- [1]. Mizushina Y, et al. The biochemical mode of inhibition of DNA polymerase β by α‑rubromycin. Biochimica et Biophysica Acta, 2000, 1523:172‑181.
- [2]. Atkinson DJ, et al. Isolation, biological activity, biosynthesis and synthetic studies towards the rubromycin family of natural products. Natural product reports. 2015 Jun;32(6):811-40.
