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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
minor groove binding
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "minor groove binding" in MCE Product Catalog:
5
5 Cited Publications
Art. -Nr.: HY-D1191
CAS. Nr.: 2225748-05-8
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1 Cited Publications
Art. -Nr.: HY-W040129
CAS. Nr.: 7059-24-7
Category:
1
1 Cited Publications
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Forschungsgebiete:
MC-Val-Cit-PAB-duocarmycin chloride is a agent-linker conjugate for ADC with potent antitumor activity by using Duocarmycin (a DNA minor groove binding alkylating agent), linked via the ADC linker MC-Val-Cit-PAB.
Art. -Nr.: HY-112899
CAS. Nr.: 169901-27-3
Forschungsgebiete:
DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.
Art. -Nr.: HY-136289
CAS. Nr.: 932744-62-2
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Forschungsgebiete:
MB-VC-MGBA is a agent-linker conjugate for ADC with potent antitumor activity by using MGBA (minor-groove-binding DNA-alkylating agent), linked via the ADC linker MB-VC .
Art. -Nr.: HY-135900
CAS. Nr.: 2412923-79-4
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Forschungsgebiete:
Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selective DNA minor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity .
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DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.
Art. -Nr.: HY-144333
CAS. Nr.: 2761734-27-2
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Forschungsgebiete:
DNA crosslinker 1 dihydrochloride (Compound 4) is a potent DNA minor groove binder with DNA binding affinity (ΔTm) of 1.1 °C. DNA crosslinker 1 dihydrochloride can be used for researching anticancer .
Art. -Nr.: HY-144336
CAS. Nr.: 2761734-21-6
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Forschungsgebiete:
DNA crosslinker 3 (dihydrochloride) (compound 1) is a potent DNA minor groove binder with DNA binding affinity (ΔTm) of 1.4 °C. DNA crosslinker 3 (dihydrochloride) can be used for researching anticancer .
Art. -Nr.: HY-129252
CAS. Nr.: 81542-99-6
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Target:
Art. -Nr.: HY-144335
CAS. Nr.: 2761734-25-0
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Forschungsgebiete:
DNA crosslinker 2 (dihydrochloride) is a potent DNA minor groove binder with DNA binding affinity (ΔTm) of 1.2 °C. DNA crosslinker 2 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 2 (dihydrochloride) can be used for researching anticancer .
Art. -Nr.: HY-DY1115
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Forschungsgebiete:
Cyanine 3.18 (TEA) (solution) is a cyanine dye and fluorescent label for biomolecules. Cyanine 3.18 (TEA) (solution) interacts with double helical DNA via intercalation, minor groove binding, or DNA-templated aggregation .
Art. -Nr.: HY-W040129R
CAS. Nr.: 7059-24-7
Category:
Art. -Nr.: HY-187697
CAS. Nr.: 915978-94-8
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Forschungsgebiete:
DB1255 is an ERG inhibitor that binds to the minor groove of DNA, with KD values of 26 nM and 86 nM for the ATGA and AATT sequences, respectively. DB1255 targets and binds to specific DNA minor grooves (single GC/AT-rich sequences), forming a hydrogen bond network with G bases and AT pairs via its thiophene group and amidino group, respectively, thereby blocking the binding of transcription factors. DB1255 can be used in the research of leukemia and prostate cancer .
Art. -Nr.: HY-N19343
CAS. Nr.: 94492-22-5
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Art. -Nr.: HY-187163
CAS. Nr.: 78831-35-3
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Forschungsgebiete:
Anticancer agent 355 is a highly selective and potent anticancer agent, with IC50 values of 64.66 μM and 13.35 μM against HeLa and MDA-MB-231 cancer cells, respectively. Anticancer agent 355 induces plasmid DNA degradation via intercalation or minor groove binding, and disrupts the tertiary structure of BSA by interfering with the interactions of amino acid side chains. Anticancer agent 355 can be used in the research of cervical cancer and breast cancer .
Art. -Nr.: HY-181060
CAS. Nr.: 952306-31-9
Forschungsgebiete:
Apoptosis inducer 56 is an apoptosis inducer. Apoptosis inducer 56 induces DNA damage (upregulation of γH2AX and p-ATM expression) by minor groove binding. Apoptosis inducer 56 induces intrinsic apoptosis (upregulation of p53 and Bax/Bcl-2 ratio, cleaved caspase-7) via S-phase cell cycle arrest. Apoptosis inducer 56 shows selectivity for cancer cells over normal breast epithelial cells. Apoptosis inducer 56 can be used for the research of breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
