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Cat. No.: HY-187163

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Anticancer agent 355

Anticancer agent 355 is a highly selective and potent anticancer agent, with IC₅₀ values of 64.66 μM and 13.35 μM against HeLa and MDA-MB-231 cancer cells, respectively. Anticancer agent 355 induces plasmid DNA degradation via intercalation or minor groove binding, and disrupts the tertiary structure of BSA by interfering with the interactions of amino acid side chains. Anticancer agent 355 can be used in the research of cervical cancer and breast cancer.

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CAS No.: 78831-35-3
화학식: C₁₆H₁₂N₂O₄
분자량:296.28

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent 355 Chemical Structure

CAS No.: 78831-35-3

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
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Calculators
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Biological Activity

제품 설명

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC50	64.66 μM	Cytotoxicity against human cervical cancer HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay. Cytotoxicity against human cervical cancer HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.	j.inoche.2020.108085
MDA-MB-231	IC50	13.35 μM	Cytotoxicity against human breast cancer MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay. Cytotoxicity against human breast cancer MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.	j.inoche.2020.108085
HEK293	IC50	82.75 μM	Cytotoxicity against normal human fibroblast HEK-293 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay. Cytotoxicity against normal human fibroblast HEK-293 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.	j.inoche.2020.108085

In Vitro

Anticancer agent 355 (Compound S4) (1-3 mg/mL; 1 h) completely degrades plasmid DNA of approximately 1 kb, exhibiting strong chemical nuclease activity^[1].
Anticancer agent 355 (9-300 μM; 24 h) exhibits cytotoxicity against HeLa and MDA-MB-231 cancer cells, with IC₅₀ values of 64.66 μM and 13.35 μM, respectively. Meanwhile, compared to normal HEK-293 cells (IC₅₀ = 82.75 μM), this agent shows high selectivity for MDA-MB-231 cells, with a selectivity coefficient of 6.19^[1].
Anticancer agent 355 (30 µM) exhibits potent DNA-binding activity via an intercalation mode in in vitro biochemical reactions^[1].
Anticancer agent 355 binds to BSA in in vitro biochemical reactions, inducing fluorescence quenching and disruption of the protein's tertiary structure^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 78831-35-3
분자량 296.28
화학식 C₁₆H₁₂N₂O₄
SMILES

O=C(C1=NC2=C3N=C(C(OC)=O)C=CC3=CC=C2C=C1)OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. De, Sourav, et al. "Highly selective and potent anti-cancer agents based on 2, 9-substituted-1, 10-phenanthroline derivatives." Inorganic Chemistry Communications 119 (2020): 108085.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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Anticancer agent 355

All DNA/RNA Synthesis Isoforms