78831-35-3
Chemical Structure
Anticancer agent 355
- CAS No.: 78831-35-3
- Formula:C16H12N2O4
- Molecular Weight:296.28
InChIKey: URMOYCVRIPQSGY-UHFFFAOYSA-N
SMILES: O=C(C1=NC2=C3N=C(C(OC)=O)C=CC3=CC=C2C=C1)OC
Biological Activity: Anticancer agent 355 is a highly selective and potent anticancer agent, with IC50 values of 64.66 μM and 13.35 μM against HeLa and MDA-MB-231 cancer cells, respectively. Anticancer agent 355 induces plasmid DNA degradation via intercalation or minor groove binding, and disrupts the tertiary structure of BSA by interfering with the interactions of amino acid side chains. Anticancer agent 355 can be used in the research of cervical cancer and breast cancer[1].
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Anticancer agent 355 | Anticancer agent 355 is a highly selective and potent anticancer agent, with IC50 values of 64.66 μM and 13.35 μM against HeLa and MDA-MB-231 cancer cells, respectively. Anticancer agent 355 induces plasmid DNA degradation via intercalation or minor groove binding, and disrupts the tertiary structure of BSA by interfering with the interactions of amino acid side chains. Anticancer agent 355 can be used in the research of cervical cancer and breast cancer. | |||||||||||||||||||||
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Keywords
