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neonatal rats

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

1

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1

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1

Inhibitory Antibodies

2

Natural
Products

1

GMP Molecules

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14785
    Befiradol

    NLX-112; F13640

    		 5-HT Receptor Neurological Disease
    Befiradol (NLX-112) is a highly selective 5-HT1A receptor agonist that acts on both presynaptic and postsynaptic sites. Befiradol attenuates fentanyl-induced respiratory depression in neonatal and adult rats. Befiradol reduces the duration of fentanyl-induced analgesia and sedation in adult rats. Befiradol can be used in studies related to opioid-induced respiratory depression .
    Befiradol
  • HY-B0277A
    Vidarabine phosphate

    ara-AMP; ara-A 5'-monophosphate

    		 EBV HSV Fungal DNA/RNA Synthesis Apoptosis Drug Intermediate Reactive Oxygen Species (ROS) Infection
    Vidarabine phosphate (ara-AMP; ara-A 5'-monophosphate) is a purine nucleoside antiviral agent and a prodrug of Vidarabine (HY-B0277). Vidarabine phosphate is rapidly converted into the antiviral active Vidarabine in vivo, which selectively inhibits viral DNA polymerase and cellular ribonucleotide reductase, thereby blocking viral replication. Vidarabine phosphate also exhibits antifungal activity, induces late-stage cellular apoptosis, and causes cell cycle arrest. Vidarabine phosphate can be used in research related to severe chronic active Epstein-Barr virus (EBV) infection, herpes infection, and candidiasis .
    Vidarabine phosphate
  • HY-N11503
    Disialyllacto-N-tetraose

    		Endogenous Metabolite Inflammation/Immunology
    Disialyllacto-N-tetraose is a human milk oligosaccharide that prevents necrotising enterocolitis in neonatal rats .
    Disialyllacto-N-tetraose
  • HY-14785A
    Befiradol hydrochloride

    NLX-112 hydrochloride; F 13640 hydrochloride

    		 5-HT Receptor Neurological Disease Metabolic Disease
    Befiradol (NLX-112) hydrochloride is a highly selective 5-HT1A receptor agonist that acts on both presynaptic and postsynaptic sites. Befiradol hydrochloride attenuates fentanyl-induced respiratory depression in neonatal and adult rats. Befiradol reduces the duration of fentanyl-induced analgesia and sedation in adult rats. Befiradol hydrochloride can be used in studies related to opioid-induced respiratory depression .
    Befiradol hydrochloride
  • HY-N11449
    Nardoaristolone B

    		Others Others
    Nardoaristolone B, a non-sesquiterpene compound isolated from the root of Nardostachys jatamansi, has protective effects on cardiomyocyte injury in neonatal rats .
    Nardoaristolone B
  • HY-107518
    (R,S)-3,4-Dicarboxyphenylglycine

    (R,S)-3,4-DCPG

    		 iGluR Neurological Disease
    (R,S)-3,4-Dicarboxyphenylglycine ((RS)-3,4-DCPG) is an AMPA receptor antagonist. (R,S)-3,4-Dicarboxyphenylglycine antagonizes AMPA-mediated depolarization of motor neurons in neonatal rats. (R,S)-3,4-Dicarboxyphenylglycine can be used in the study of neurological diseases .
    (R,S)-3,4-Dicarboxyphenylglycine
  • HY-162729
    LSD1-IN-34

    		Histone Demethylase Monoamine Oxidase TGF-beta/Smad Cardiovascular Disease
    LSD1-IN-34 (Compound 7d) is the orally active inhibitor for Lysine-specific demethylase (LSD) and monoamine oxidase (MAO), with IC50 of 4.51 and 18.46 nM, for LSD1 and MAO A. LSD1-IN-34 inhibits the Ang II-induced neonatal rat myocardial fibroblasts (NRCFs) activation, without significant toxicity (20 μM). LSD1-IN-34 inhibits TGFβ/Smad signaling pathway, and ameliorates heart failure in mice. LSD1-IN-34 exhibits good pharmacokinetic characteristics in rats .
    LSD1-IN-34
  • HY-112005G
    DOPE

    Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

    		 Ferroptosis Glutathione Peroxidase ACSL Family Amino acid Transporter Neurological Disease Inflammation/Immunology
    DOPE GMP is DOPE (HY-112005) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOPE (Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine) is an orally active inhibitor of ferroptosis with anti-inflammatory and intestinal barrier maintenance activities. DOPE regulates the expression of ACSL4, SLC7A11 and GPX4 to restore the redox system balance, thereby reducing the levels of lipid peroxides, iron ions and intestinal inflammatory factors (IL-1β and IL-6). DOPE promotes the migration and proliferation of intestinal epithelial cells and increases the level of tight junction proteins; it also destabilizes endosomal membranes, mediates the conjugation of RVG peptides with mesenchymal stem cell-derived exosomes to enhance brain targeting. DOPE can be applied to research related to neonatal necrotizing enterocolitis and Alzheimer's disease .
    DOPE
  • HY-P992152
    Vatreptacog alfa

    		Factor VIIa Drug Derivative Cardiovascular Disease
    Vatreptacog alfa is a recombinant hFVIIa analog, differing from native FVIIa by three amino acid substitutions (V158D, E296V and M298Q) in the protease domain. Vatreptacog alfa exhibits enhanced tissue factor-independent enzymatic activity toward activated platelets. Vatreptacog alfa can be used in the research of hemophilia .
    Vatreptacog alfa

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