29984-33-6
Chemical Structure
Vidarabine phosphate
Synonym(s): ara-AMP; ara-A 5'-monophosphate
- CAS No.: 29984-33-6
- Formula:C10H14N5O7P
- Molecular Weight:347.22
IUPAC Name: ((2R,3S,4S,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate
InChIKey: UDMBCSSLTHHNCD-UHTZMRCNSA-N
SMILES: NC1=C(N=CN2[C@H]3[C@@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O3)C2=NC=N1
Biological Activity: Vidarabine phosphate (ara-AMP; ara-A 5'-monophosphate) is a purine nucleoside antiviral agent and a prodrug of Vidarabine (HY-B0277). Vidarabine phosphate is rapidly converted into the antiviral active Vidarabine in vivo, which selectively inhibits viral DNA polymerase and cellular ribonucleotide reductase, thereby blocking viral replication. Vidarabine phosphate also exhibits antifungal activity, induces late-stage cellular apoptosis, and causes cell cycle arrest. Vidarabine phosphate can be used in research related to severe chronic active Epstein-Barr virus (EBV) infection, herpes infection, and candidiasis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Vidarabine phosphate | 99.44% | Vidarabine phosphate (ara-AMP; ara-A 5'-monophosphate) is a purine nucleoside antiviral agent and a prodrug of Vidarabine (HY-B0277). Vidarabine phosphate is rapidly converted into the antiviral active Vidarabine in vivo, which selectively inhibits viral DNA polymerase and cellular ribonucleotide reductase, thereby blocking viral replication. Vidarabine phosphate also exhibits antifungal activity, induces late-stage cellular apoptosis, and causes cell cycle arrest. Vidarabine phosphate can be used in research related to severe chronic active Epstein-Barr virus (EBV) infection, herpes infection, and candidiasis. | ||||||||||||||||||||
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Vidarabine phosphate (Standard) | ≥98% | Vidarabine phosphate (ara-AMP; ara-A 5'-monophosphate) (Standard) is the analytical standard of Vidarabine phosphate. This product is intended for research and analytical applications. Vidarabine phosphate is a purine nucleoside antiviral agent and a prodrug of Vidarabine (HY-B0277). Vidarabine phosphate is rapidly converted into the antiviral active Vidarabine in vivo, which selectively inhibits viral DNA polymerase and cellular ribonucleotide reductase, thereby blocking viral replication. Vidarabine phosphate also exhibits antifungal activity, induces late-stage cellular apoptosis, and causes cell cycle arrest. Vidarabine phosphate can be used in research related to severe chronic active Epstein-Barr virus (EBV) infection, herpes infection, and candidiasis. | ||||||||||||||||||||
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- [1]. Kimura H, et al. Vidarabine therapy for severe chronic active Epstein-Barr virus infection. J Pediatr Hematol Oncol. 2001;23(5):294-299. [Content Brief]
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[2]. Gough AW, et al. Comparison of the neonatal toxicity of two antiviral agents: Vidarabine phosphate and cytarabine. Toxicology and applied pharmacology. 1982 Oct 1;66(1):143-52.
- [3]. Gavandi TC, et al. Vidarabine as a novel antifungal agent against Candida albicans: insights on mechanism of action. Int Microbiol. 2025;28(3):589-602. [Content Brief]
