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neural tube defects

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By Targets:	Antifolate (4) DNA/RNA Synthesis (5) Drug Derivative (3) Endogenous Metabolite (6) Environmental Pollutants (1) HDAC (1) Isotope-Labeled Compounds (2) P-glycoprotein (1) Reference Standards (3)
By Research Areas:	Cancer (7) Cardiovascular Disease (6) Infection (1) Metabolic Disease (2) Neurological Disease (12)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16637

Folic acid Maximum Cited Publications 25 Publications Verification Vitamin B9; Vitamin M	Environmental Pollutants Endogenous Metabolite DNA/RNA Synthesis	Cardiovascular Disease Infection Neurological Disease Cancer
Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency .

HY-17383

Levomefolate calcium 3 Publications Verification	Antifolate	Cardiovascular Disease Neurological Disease
Levomefolate calcium is a synthetic calcium salt of L-5-methyltetrahydrofolate and an orally active and brain-penetrant folate supplement. Levomefolate calcium incorporates into body folate pools to increase plasma and red blood cell folate levels over time. Levomefolate calcium does not significantly increase folate concentrations in breast milk. Levomefolate calcium can be used for the research of neural tube defects and megaloblastic anemia .

HY-16637R

Folic acid (Standard) 1 Publications Verification Vitamin B9 (Standard); Vitamin M (Standard)	Reference Standards DNA/RNA Synthesis Endogenous Metabolite	Neurological Disease Cancer
Folic acid (Standard) is the analytical standard of Folic acid. This product is intended for research and analytical applications. Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency .

HY-17557

Calcium N5-methyltetrahydrofolate 5+ Cited Publications NSC173328; 5-Methyl THF calcium	Drug Derivative	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Calcium N5-methyltetrahydrofolate (NSC173328; 5-Methyl THF (calcium)), Levomefolic acid (HY-14781) derivative, is a folic acid supplement. Calcium N5-methyltetrahydrofolate can be used for the research of neural tube defects, infertility, non-hodgkin's lymphoma, endometriosis .

HY-16637D

Folic acid disodium Maximum Cited Publications 25 Publications Verification Vitamin B9 disodium; Vitamin M disodium	Endogenous Metabolite DNA/RNA Synthesis	Others Neurological Disease Cancer
Folic acid disodium (Vitamin B9 disodium; Vitamin M disodium) is an orally active disodium salt form of Folic acid (HY-16637) with an intrinsic dissolution rate (IDR) of 4.96·10 ⁵ g/s . Folic acid disodium serves as cofactor in single-carbon transfer reactions and exhibits protective effects against neural tube defects, ischemic events, and cancer. Folate acid disodium overload leads to impaired brain development in embryogenesis and promotes growth of precancerous altered cells. Folic acid deficiency leads to megaloblastic anemia .

HY-16637A

Folic acid sodium Vitamin B9 sodium; Vitamin M sodium	DNA/RNA Synthesis Endogenous Metabolite	Neurological Disease
Folic acid (Vitamin B9) sodium is a orally active essential nutrient from the B complex group of vitamins. Folic acid sodium shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid sodium can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency .

HY-B0430B

(±)-Pantothenic acid (±)-Pantothenate; (±)-Vitamin B5	Endogenous Metabolite	Neurological Disease Metabolic Disease
(±)-Pantothenic acid ((±)-Pantothenate), a B-vitamin, is an essential vitamin required for the biosynthesis of coenzyme A (CoA) in mammalian cells. Pantothenic acid has protective activity against valproic acid (VPA)-induced neural tube defects (NTD) in CD-1 mice .

HY-16637S5

Folic acid-13C6 Vitamin B9-¹³C₆; Vitamin M-¹³C₆	Isotope-Labeled Compounds DNA/RNA Synthesis Endogenous Metabolite	Cancer
Folic acid-13C6 is a deuterated labeled Folic acid . Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency .

HY-17383R

Levomefolate calcium (Standard)	Reference Standards Antifolate	Cardiovascular Disease Neurological Disease
Levomefolate calcium (Standard) is the analytical standard of Levomefolate calcium. This product is intended for research and analytical applications. Levomefolate calcium is a synthetic calcium salt of L-5-methyltetrahydrofolate and an orally active and brain-penetrant folate supplement. Levomefolate calcium incorporates into body folate pools to increase plasma and red blood cell folate levels over time. Levomefolate calcium does not significantly increase folate concentrations in breast milk. Levomefolate calcium can be used for the research of neural tube defects and megaloblastic anemia .

HY-133160

Valproic acid hydroxamate VPA-HA	Drug Derivative	Neurological Disease
Valproic acid hydroxamate (VPA-HA) has shown anticonvulsant activity in a mouse neural tube defect model, without any teratogenic effects .

HY-17383A

Levomefolate disodium	Antifolate	Neurological Disease
Levomefolate disodium is a synthetic disodium salt of L-5-methyltetrahydrofolate and an orally active and brain-penetrant folate supplement. Levomefolate disodium incorporates into body folate pools to increase plasma and red blood cell folate levels over time. Levomefolate disodium does not significantly increase folate concentrations in breast milk. Levomefolate disodium can be used for the research of neural tube defects and megaloblastic anemia .

HY-17557R

Calcium N5-methyltetrahydrofolate (Standard) NSC173328 (Standard); 5-Methyl THF calcium (Standard)	Reference Standards Drug Derivative	Cardiovascular Disease Cancer
Calcium N5-methyltetrahydrofolate (Standard) is the analytical standard of Calcium N5-methyltetrahydrofolate (HY-17557). This product is intended for research and analytical applications. Calcium N5-methyltetrahydrofolate (NSC173328; 5-Methyl THF (calcium)), Levomefolic acid (HY-14781) derivative, is a folic acid supplement. Calcium N5-methyltetrahydrofolate can be used for the research of neural tube defects, infertility, non-hodgkin's lymphoma, endometriosis .

HY-17383S

Levomefolate-13C5 calcium	Isotope-Labeled Compounds Antifolate	Cardiovascular Disease Neurological Disease
Levomefolate- ¹³C₅ calcium)is the ¹³C-labeled Levomefolate calcium (HY-17383). Levomefolate calcium is a synthetic calcium salt of L-5-methyltetrahydrofolate and an orally active and brain-penetrant folate supplement. Levomefolate calcium incorporates into body folate pools to increase plasma and red blood cell folate levels over time. Levomefolate calcium does not significantly increase folate concentrations in breast milk. Levomefolate calcium can be used for the research of neural tube defects and megaloblastic anemia .

HY-W787758

2-Propylpent-4-ynoic acid 4-yn-VPA	HDAC P-glycoprotein	Neurological Disease Cancer
2-Propylpent-4-ynoic acid (4-yn-VPA) is a HDAC inhibitor (with an IC₅₀ of 0.5 mM against human HDAC). 2-Propylpent-4-ynoic acid also induces P-glycoprotein function, and exhibits teratogenicity, fetal growth inhibition and neurotoxicity. 2-Propylpent-4-ynoic acid shows significant stereospecific teratogenic effects, with the S-enantiomer being more teratogenic than the R-enantiomer and other analogs. The neurotoxicity of 2-Propylpent-4-ynoic acid is independent of its stereochemical structure. 2-Propylpent-4-ynoic acid has been used in studies related to the pathogenesis of colon cancer and neural tube defects such as exencephaly .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-16637

Folic acid Maximum Cited Publications 25 Publications Verification Vitamin B9; Vitamin M	Structural Classification Neurological Disease Classification of Application Fields Anti-aging Endocrine diseases Plants Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms other families Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Disease Research Fields Source Classification Cancer	Environmental Pollutants Endogenous Metabolite DNA/RNA Synthesis
Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency .

HY-16637R

Folic acid (Standard) 1 Publications Verification Vitamin B9 (Standard); Vitamin M (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms other families Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Plants Endogenous metabolite Source Classification	Reference Standards DNA/RNA Synthesis Endogenous Metabolite
Folic acid (Standard) is the analytical standard of Folic acid. This product is intended for research and analytical applications. Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency .

HY-16637D

Folic acid disodium Maximum Cited Publications 25 Publications Verification Vitamin B9 disodium; Vitamin M disodium	Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite DNA/RNA Synthesis
Folic acid disodium (Vitamin B9 disodium; Vitamin M disodium) is an orally active disodium salt form of Folic acid (HY-16637) with an intrinsic dissolution rate (IDR) of 4.96·10 ⁵ g/s . Folic acid disodium serves as cofactor in single-carbon transfer reactions and exhibits protective effects against neural tube defects, ischemic events, and cancer. Folate acid disodium overload leads to impaired brain development in embryogenesis and promotes growth of precancerous altered cells. Folic acid deficiency leads to megaloblastic anemia .

HY-16637A

Folic acid sodium Vitamin B9 sodium; Vitamin M sodium	Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	DNA/RNA Synthesis Endogenous Metabolite
Folic acid (Vitamin B9) sodium is a orally active essential nutrient from the B complex group of vitamins. Folic acid sodium shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid sodium can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency .

HY-B0430B

(±)-Pantothenic acid (±)-Pantothenate; (±)-Vitamin B5	Other disease Disease markers Endogenous metabolite	Endogenous Metabolite
(±)-Pantothenic acid ((±)-Pantothenate), a B-vitamin, is an essential vitamin required for the biosynthesis of coenzyme A (CoA) in mammalian cells. Pantothenic acid has protective activity against valproic acid (VPA)-induced neural tube defects (NTD) in CD-1 mice .

Cat. No.	Product Name	Chemical Structure

HY-16637S5

Folic acid-13C6
Folic acid-13C6 is a deuterated labeled Folic acid . Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency .

HY-17383S

Levomefolate-13C5 calcium
Levomefolate- ¹³C₅ calcium)is the ¹³C-labeled Levomefolate calcium (HY-17383). Levomefolate calcium is a synthetic calcium salt of L-5-methyltetrahydrofolate and an orally active and brain-penetrant folate supplement. Levomefolate calcium incorporates into body folate pools to increase plasma and red blood cell folate levels over time. Levomefolate calcium does not significantly increase folate concentrations in breast milk. Levomefolate calcium can be used for the research of neural tube defects and megaloblastic anemia .

Levomefolate-13C5 calcium

Levomefolate- ¹³C₅ calcium)is the ¹³C-labeled Levomefolate calcium (HY-17383). Levomefolate calcium is a synthetic calcium salt of L-5-methyltetrahydrofolate and an orally active and brain-penetrant folate supplement. Levomefolate calcium incorporates into body folate pools to increase plasma and red blood cell folate levels over time. Levomefolate calcium does not significantly increase folate concentrations in breast milk. Levomefolate calcium can be used for the research of neural tube defects and megaloblastic anemia .

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neural tube defects

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products