3 Results for "

neuronal resistance

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "neuronal resistance" in MCE Product Catalog:

Roemerine
Roemerine
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Cat. No.: HY-121793
CAS No.: 548-08-3
Purity:  99.61%
Synonyms: (-)-Roemerine
Category:  

Aporphine Alkaloids Fibraurea recisa Pierre Plants Nymphaeaceae Menispermaceae Alkaloids Nelumbo nucifera Gaertn. Disease Research Fields Isoquinoline Alkaloids Cancer

Target:  

Endogenous Metabolite 5-HT Receptor mGluR iGluR Bacterial Antibiotic

Roemerine is an alkaloid that has been identified from the leaves of Fibraurea recisa Pierre. Roemerine exhibits antibacterial, anticancer, and antidepressant activities, can reverse the multidrug resistance phenotype in cultured cells, and exerts antibacterial effects by regulating the cAMP signaling pathway. Additionally, Roemerine influences neuronal activity by increasing BDNF protein expression and modulating the serotonergic and glutamatergic systems. Roemerine holds promise for research in the fields of cancer, infections, and neurological diseases .
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(rac)-AG-205
(rac)-AG-205
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Cat. No.: HY-121012
CAS No.: 442656-02-2
Target:  

NF-κB Akt

Research Areas:  

Endocrinology

(rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway .
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(Pyr3)-Amyloid β-Protein (3-42)
(Pyr3)-Amyloid β-Protein (3-42)
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Cat. No.: HY-P4882
CAS No.: 183449-57-2
Target:  

Amyloid-β Tau Protein

Research Areas:  

Neurological Disease

(Pyr3)-Amyloid β-Protein (3-42) is an N-terminally truncated pyroglutamylated β-amyloid peptide. (Pyr3)-Amyloid β-Protein (3-42) forms stable β-sheet structures across different pH values, co-oligomerizes with Aβ1-42 to form cytotoxic oligomers, induces tau-dependent cytotoxicity and neuronal loss, inhibits hippocampal LTP, and exhibits stronger protease resistance. (Pyr3)-Amyloid β-Protein (3-42) exists in the brain tissues of human Alzheimer's disease patients, correlates with the pathogenesis of Alzheimer's disease, and follows a unique, faster oligomerization pathway. (Pyr3)-Amyloid β-Protein (3-42) can be used in Alzheimer's disease-related research .
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