150 Results for "

neurotrophic factor

" in MedChemExpress (MCE) Product Catalog:
Products (150)

150 Results for "neurotrophic factor" in MCE Product Catalog:

21
21 Publications Verification
Cat. No.: HY-W013372
CAS No.: 38183-03-8
7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases .
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15
15 Cited Publications
Cat. No.: HY-P7116A
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BDNF; Abrineurin; Brain Derived neurotrophic factor; Brain-Derived neurotrophic factor Preproprotein Isoform 2; ProBDNF; Brain-Derived neurotrophic factor Isoform 1; neurotrophic factor BDNF Precursor Form; ANON2; Brain-Derived neurotrophic factor; BULN2
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5
5 Cited Publications
Cat. No.: HY-P7182
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GDNF; ATF2; Glial Cell Derived neurotrophic factor; ATF; Astrocyte-Derived Trophic factor; Glial Cell Line Derived neurotrophic factor; Glial Cell Line-Derived neurotrophic factor; Glial Derived neurotrophic factor; HFB1-GDNF; HSCR3; ATF1; HGDNF
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5
5 Cited Publications
Cat. No.: HY-P0221
CAS No.: 137061-48-4
Synonyms: Pituitary Adenylate Cyclase Activating Polypeptide 38
PACAP (1-38), human, ovine, rat is a PAC1 receptor agonist. PACAP (1-38), human, ovine, rat binds to PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 with IC50s of 4 nM, 2 nM, and 1 nM, respectively. PACAP (1-38), human, ovine, rat increases the α-secretase activity. PACAP (1-38), human, ovine, rat elevates cytosolic Ca 2+, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP (1-38), human, ovine, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP (1-38), human, ovine, rat can be used for neurotrophic and neuroprotective research .
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4
4 Cited Publications
Cat. No.: HY-151527
CAS No.: 2708177-73-3
Purity:  98.64%
Research Areas:  

Neurological Disease

PI3K/Akt/CREB activator 1 (compound AE-18) is a potent, orally active PI3K/Akt/CREB activator. PI3K/Akt/CREB activator 1 promotes neuronal proliferation, induced differentiation of Neuro-2a cells into a neuron-like morphology, and accelerated the establishment of axon-dendrite polarization of primary hippocampal neurons through upregulating brain-derived neurotrophic factor via the PI3K/Akt/CREB pathway. PI3K/Akt/CREB activator 1 can be used in research of vascular dementia (VaD) .
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3
3 Cited Publications
Cat. No.: HY-P74383
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BDNF; Abrineurin; Brain Derived neurotrophic factor; Brain-Derived neurotrophic factor Preproprotein Isoform 2; ProBDNF; Brain-Derived neurotrophic factor Isoform 1; neurotrophic factor BDNF Precursor Form; ANON2; Brain-Derived neurotrophic factor; BULN2
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2
2 Cited Publications
Cat. No.: HY-P70456
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NTF3; Neurotrophin-3; Neurotrophin 3; NGF-2; NGF2; HDNF; Nerve Growth factor 2; NT-3; neurotrophic factor; NT3
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2
2 Cited Publications
Cat. No.: HY-P7359
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GDNF; ATF2; Glial Cell Derived neurotrophic factor; ATF; Astrocyte-Derived Trophic factor; Glial Cell Line Derived neurotrophic factor; Glial Cell Line-Derived neurotrophic factor; Glial Derived neurotrophic factor; HFB1-GDNF; HSCR3; ATF1; HGDNF
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CHO
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2
2 Cited Publications
Cat. No.: HY-P7145
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CNTF; HCNTF; Ciliary neurotrophic factor; Ciliary Neuronotrophic factor
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2
2 Cited Publications
Cat. No.: HY-P71940A
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MANF; Arginine-Rich, Mutated In Early Stage Tumors; Prev. ARMET; Protein ARMET; ARP; DDDS; Mesencephalic Astrocyte-Derived neurotrophic factor; Mesencephalic Astrocyte Derived neurotrophic factor; Arginine-Rich Protein
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1
1 Cited Publications
Cat. No.: HY-D0889
CAS No.: 556-50-3
Synonyms: Gly-Gly; H-Gly-Gly-OH
Glycylglycine is a non-selective glycylglycine dipeptidase substrate and iNOS inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) .
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1
1 Cited Publications
Cat. No.: HY-106353
CAS No.: 126-18-1
Purity:  ≥98.0%
Smilagenin (SMI) is a small-molecule steroidal sapogenin from Anemarrhena asphodeloides and Pelargonium hortorum widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases . Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density . Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD .
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1
1 Cited Publications
Cat. No.: HY-105066
CAS No.: 211439-12-2
Purity:  99.64%
Research Areas:  

Neurological Disease

Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity .
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1
1 Cited Publications
Cat. No.: HY-111969
CAS No.: 924811-53-0
Purity:  99.77%
Target:  

GDNF Receptor

Research Areas:  

Neurological Disease

BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF) . BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function .
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1
1 Cited Publications
Cat. No.: HY-N3297
CAS No.: 5875-49-0
Meranzin hydrate is an orally active antidepressant and GHSR modulator. Meranzin hydrate significantly upregulates the expression levels of brain-derived neurotrophic factor and p-mTOR in the hippocampus via the ghrelin-growth hormone secretagogue receptor pathway. Meranzin hydrate regulates blood oxygen level-dependent signals in the hippocampus-thalamus-basal ganglia circuit, attenuates reward system activation, and promotes the normalization of related hormone levels. Meranzin hydrate effectively ameliorates depression-like behaviors and gastrointestinal hypomotility, and can be used in research related to depression and major depressive disorder .
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1
1 Cited Publications
Cat. No.: HY-P700158AF
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BDNF; Abrineurin; Brain Derived neurotrophic factor; Brain-Derived neurotrophic factor Preproprotein Isoform 2; ProBDNF; Brain-Derived neurotrophic factor Isoform 1; neurotrophic factor BDNF Precursor Form; ANON2; Brain-Derived neurotrophic factor; BULN2
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1
1 Cited Publications
Cat. No.: HY-P73074
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GDNF; ATF2; Glial Cell Derived neurotrophic factor; ATF; Astrocyte-Derived Trophic factor; Glial Cell Line Derived neurotrophic factor; Glial Cell Line-Derived neurotrophic factor; Glial Derived neurotrophic factor; HFB1-GDNF; HSCR3; ATF1; HGDNF
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1
1 Cited Publications
Cat. No.: HY-P7146
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CNTF; HCNTF; Ciliary neurotrophic factor; Ciliary Neuronotrophic factor
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1
1 Cited Publications
Cat. No.: HY-P7147
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CNTF; HCNTF; Ciliary neurotrophic factor; Ciliary Neuronotrophic factor
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1
1 Cited Publications
Cat. No.: HY-P7148
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CNTF; HCNTF; Ciliary neurotrophic factor; Ciliary Neuronotrophic factor
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Rat
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