2708177-73-3
Chemical Structure
PI3K/Akt/CREB activator 1
- CAS No.: 2708177-73-3
- Formula:C19H15F4NO3
- Molecular Weight:381.32
IUPAC Name: (S,E)-3-(4-fluorophenyl)-2-(3-(4-(trifluoromethyl)phenyl)acrylamido)propanoic acid
InChIKey: VXTNIOWCDILANK-YKXBDCQTSA-N
SMILES: O=C(N[C@H](C(O)=O)CC1=CC=C(C=C1)F)/C=C/C2=CC=C(C=C2)C(F)(F)F
Biological Activity: PI3K/Akt/CREB activator 1 (compound AE-18) is a potent, orally active PI3K/Akt/CREB activator. PI3K/Akt/CREB activator 1 promotes neuronal proliferation, induced differentiation of Neuro-2a cells into a neuron-like morphology, and accelerated the establishment of axon-dendrite polarization of primary hippocampal neurons through upregulating brain-derived neurotrophic factor via the PI3K/Akt/CREB pathway. PI3K/Akt/CREB activator 1 can be used in research of vascular dementia (VaD)[1].
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PI3K/Akt/CREB activator 1 | 98.64% | PI3K/Akt/CREB activator 1 (compound AE-18) is a potent, orally active PI3K/Akt/CREB activator. PI3K/Akt/CREB activator 1 promotes neuronal proliferation, induced differentiation of Neuro-2a cells into a neuron-like morphology, and accelerated the establishment of axon-dendrite polarization of primary hippocampal neurons through upregulating brain-derived neurotrophic factor via the PI3K/Akt/CREB pathway. PI3K/Akt/CREB activator 1 can be used in research of vascular dementia (VaD). | ||||||||||||||||||||
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Keywords
