3 Results for "

normal colonic epithelial cells

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "normal colonic epithelial cells" in MCE Product Catalog:

Cat. No.: HY-184950
CAS No.: 2458170-55-1
Research Areas:  

Cancer

eEF2K ligand-1 is a PROTAC target protein ligand that targets eEF2K, and it is applicable to research related to PROTAC synthesis. eEF2K ligand-1 serves as the target protein of PROTAC eEF2K degrader-1 (HY-146324) .
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Cat. No.: HY-189293
Target:  

PARP

Research Areas:  

Cancer

PARP1 degrader-3 is a selective PARP1 degrader derived from Olaparib (HY-10162) bearing a bicyclo[1.1.1]pentane (BCP) hydrophobic tag. PARP1 degrader-3 degrades PARP1 with a DC50 of 4.31 μM. PARP1 degrader-3 induces PARP1 degradation primarily through the ubiquitin-proteasome system, and the HSP70/HSP90-associated protein quality control pathway may be involved in this process. PARP1 degrader-3 can be used for colorectal cancer-related research .
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Cat. No.: HY-138794G
CAS No.: 2417089-74-6
XL177A GMP is XL177A (HY-138794) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. XL177A is a covalent USP7 inhibitor that blocks the deubiquitinase activity of USP7. XL177A destabilizes non-canonical PRC1 complexes or KDM6A and reduces chromatin deposition of H2AK119Ub, thereby relieving the repression of neuronal differentiation programs. Meanwhile, XL177A also regulates the ELOF1-UVSSA-USP7-nuclear β-catenin axis, decreasing the transcription levels of related proteins and the accumulation of nuclear β-catenin. XL177A exerts antiviral effects by reducing the expression levels of coronavirus receptors, and exhibits inhibitory activity against APC-mutated colorectal cancer cells, neuroblastoma, and coronaviruses including SARS-CoV-2 variants. XL177A is mainly used in studies related to colorectal cancer, neuroblastoma, and coronavirus infections .
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