Search Result

Results for "

oligomer

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) AMPK (1) Amylin Receptor (2) Amyloid-β (57) Antibiotic (2) Antibody-Oligonucleotide Conjugates (AOCs) (2) Apoptosis (10) Arp2/3 Complex (1) Autophagy (10) Bacterial (11) Bcl-2 Family (2) Biochemical Assay Reagents (11) Calcium Channel (1) CaMK (2) Carbonic Anhydrase (1) Caspase (2) Cathepsin (1) CDK (1) CGRP Receptor (1) Cholinesterase (ChE) (2) DNA/RNA Synthesis (5) Dopamine Receptor (1) Drug Derivative (1) Drug Intermediate (4) Drug Metabolite (1) Dynamin (1) DYRK (1) Dystrophin (3) Endogenous Metabolite (10) Environmental Pollutants (1) ERK (2) Ferroptosis (1) Fluorescent Dye (5) GABA Receptor (1) Gap Junction Protein (1) GHR (2) GLP Receptor (1) GSK-3 (2) iGluR (2) Isotope-Labeled Compounds (3) JNK (1) Keap1-Nrf2 (1) Mitochondrial Metabolism (1) MOFs (1) Molecular Glues (1) p38 MAPK (2) PAI-1 (1) Phosphatase (3) Phosphodiesterase (PDE) (1) Phospholipase (1) Phosphoramidites (1) PKC (1) Pyk2 (1) Reactive Oxygen Species (ROS) (2) Reference Standards (7) STING (1) Tau Protein (4) Telomerase (1) TNF Receptor (1) Transferrin Receptor (1) Trk Receptor (1) Tyrosine Hydroxylase (1) α-synuclein (11) γ-secretase (1)
By Research Areas:	Cancer (21) Cardiovascular Disease (5) Endocrinology (1) Infection (8) Inflammation/Immunology (8) Metabolic Disease (7) Neurological Disease (88)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Other Phosphoramidite (2) Phosphoramidites (2) Antisense Oligonucleotides (7)

134

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-N0148

Rutin Maximum Cited Publications 30 Publications Verification Rutoside; Quercetin 3-O-rutinoside	Amyloid-β Autophagy Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a CBR1 inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

HY-101855

Emrusolmin Anle138b	Amyloid-β	Neurological Disease
Emrusolmin (Anle138b), an oligomeric aggregation inhibitor, blocks the formation of pathological aggregates of prion protein (PrPSc) and of α-synuclein (α-syn). Emrusolmin strongly inhibits oligomer accumulation, neuronal degeneration, and disease progression in vivo. Emrusolmin has low toxicity and an excellent oral bioavailability and blood-brain-barrier penetration. Emrusolmin blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology .

HY-N0148A

Rutin hydrate Maximum Cited Publications 30 Publications Verification Rutoside hydrate; Quercetin 3-O-rutinoside hydrate	Amyloid-β Autophagy Apoptosis Endogenous Metabolite	Neurological Disease Cancer
Rutin (Rutoside) hydrate is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin hydrate can cross the blood brain barrier. Rutin hydrate attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

HY-N2581

Phytic acid sodium salt 1 Publications Verification myo-Inositol, hexakisdihydrogen phosphate sodium salt; Inositol hexaphosphate sodium salt	MOFs Endogenous Metabolite Amyloid-β Autophagy	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Phytic acid (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) sodium salt is an orally active compound. Phytic acid sodium salt can be derived from the seeds of legumes. Phytic acid sodium salt is a [PO4] ³- storage depot and precursor for other inositol phosphates and pyrophosphates. Phytic acid sodium salt attenuates Aβ oligomers and upregulates autophagy protein. Phytic acid sodium salt can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research .

HY-112108

Chitosan oligosaccharide 5 Publications Verification COS	AMPK Endogenous Metabolite	Metabolic Disease Cancer
Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. Chitosan oligosaccharide (COS) activates AMPK and inhibits inflammatory signaling pathways including NF-κB and MAPK pathways.

HY-132611

Golodirsen SRP-4053	Dystrophin DNA/RNA Synthesis	Neurological Disease
Golodirsen (SRP-4053) is an antisense oligonucleotide of the phophorodiamidate morpholino oligomer (PMO). Golodirsen restores the reading frame of the Duchenne muscular dystrophy (DMD) gene by modifying the splicing process of the pre-mRNA, skipping exon 53. Golodirsen can restore the expression of the anti-myostatin protein. Golodirsen can be used for the research of duchenne muscular dystrophy (DMD) .

HY-13915

NSC348884 3 Publications Verification	Apoptosis	Cancer
NSC348884 is a nucleophosmin (NPM) inhibitor, it disrupts oligomer formation and induces apoptosis, inhibits cell proliferation with IC₅₀s of 1.7-4.0 μM in distinct cancer cell lines. NSC348884 can be used for the research of cancer .

HY-117259

Valiltramiprosate 1 Publications Verification ALZ-801	Amyloid-β	Neurological Disease
ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound . ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease .

HY-W143216

Azure C Monomethylthionine	Amyloid-β Tau Protein	Neurological Disease
Azure C acts as a tau oligomer modulator and Aβ42 oligomerization inhibitor. It regulates hsp70 ATPase activity, thereby mediating the clearance of tau protein. Azure C reduces the levels of toxic tau oligomers by promoting the formation of non-toxic tau aggregates, rescues neuroblastoma cells from tau oligomer-induced toxicity, and binds to and inhibits Aβ42 oligomerization without suppressing its fibrillization. Azure C is generated via sequential oxidation of methylene blue or Azure B through a horseradish peroxidase-mediated reaction, and accumulates in HRP reaction media. Azure C can be used in studies related to tauopathies, including Alzheimer's disease .

HY-N7697

Chitotetraose tetrahydrochloride	Others	Others
Chitotetraose tetrahydrochloride is a short-chain chitin oligomer derived from arbuscular mycorrhizal (AM) fungi. Chitotetraose tetrahydrochloride activates the AM fungus-dependent conserved symbiotic signaling pathway (CSSP) in actinorhizal plant species .

HY-113788

PF-719	Pyk2 p38 MAPK Amyloid-β	Neurological Disease Inflammation/Immunology
PF-719 is a highly selective Pyk2 inhibitor with an IC₅₀ value of 17 nM. PF-719 promotes the activation of LKB1 and p38 MAPK. PF-719 blocks synaptic deficits induced by Amyloid-beta oligomers and reverses the inhibition of long-term potentiation induced by β-amyloid oligomers. PF-719 can be used in research related to Alzheimer's disease and autoimmune diseases .

HY-D0874

HEPPSO	Biochemical Assay Reagents	Others
HEPPSO is a zwitterionic Good's buffer suitable for physiological pH conditions. HEPPSO forms high-order oligomers in aqueous solutions and can form a 1:1 complex with Cu ²⁺ via its hydroxyalkyl and tertiary amine groups. However, HEPPSO contains a structurally similar trace impurity lacking an alkanesulfonic acid side chain. The complex formed by this impurity and Cu ²⁺ has a very low Ka; therefore, HEPPSO may interfere with studies on copper speciation analysis in natural water bodies .

HY-145580

Minzasolmin UCB0599; (R)-NPT200-11	α-synuclein	Neurological Disease
Minzasolmin (UCB0599; (R)-NPT200-11) is an orally active, blood-brain-permeable α-synuclein (α-Syn) inhibitor that selectively binds to α-Syn misfolded intermediates (such as oligomers) and inhibits aggregation and fibril formation by regulating their conformational stability. Minzasolmin can reduce the generation of pathological oligomers and block neurotoxic signaling, thereby reducing the abnormal accumulation of α-Syn in the brain. Minzasolmin significantly improved motor deficits, reduced neuroinflammatory markers, and α-Syn-related pathological deposition in transgenic mouse models .

HY-N2048

2,2':5',2''-Terthiophene α-Terthiophene; α-Terthienyl; Trithiophene	Environmental Pollutants Antibiotic Bacterial	Infection
2,2':5',2''-Terthiophene (α-Terthiophene) is an oligomer of the heterocycle thiophene. 2,2':5',2''-Terthiophene has been employed as building block for the organic semi-conductor polythiophene.

HY-Y1230

4-Pentynoic acid Propargylacetic acid	Biochemical Assay Reagents	Others
4-Pentynoic acid (Propargylacetic acid) is an intermediate to produce biologically active compounds. 4-Pentynoic acid is widely utilized as a building block for the synthesis of eight sequence-defined model oligomers . 4-Pentynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-121035

7BIO 7-Bromoindirubin-3-Oxime	CDK GSK-3	Neurological Disease
7BIO (7-Bromoindirubin-3-Oxime) is the derivate of indirubin. 7BIO (7-Bromoindirubin-3-Oxime) has inhibitory effects against cyclin-dependent kinase-5 (CDK5) and glycogen synthase kinase-3β (GSK3β). 7BIO (7-Bromoindirubin-3-Oxime) inhibits Aβ oligomer-induced neuroinflammation, synaptic impairments, tau hyper-phosphorylation, activation of astrocytes and microglia, and attenuates Aβ oligomer-induced cognitive impairments in mice ^[1].

HY-160791

Claramine	Phosphatase	Infection Cancer
Claramine is a steroid polyamine with blood-brain barrier permeability. Claramine can regulate the properties of lipid membranes and protect cells from various biological toxins, including misfolded protein oligomers and biological protein-based toxins .

HY-139324

Cu(II)GTSM 1 Publications Verification	GSK-3 Amyloid-β	Neurological Disease Cancer
Cu(II)GTSM, a cell-permeable Cu-complex, significantly inhibits GSK3β. Cu(II)GTSM inhibits Amyloid-β oligomers (AβOs) and decreases tau phosphorylation. Cu(II)GTSM also decreases the abundance of Amyloid-β trimers. Cu(II)GTSM is a potential anticancer and antimicrobial agent .

HY-132611A

Golodirsen sodium SRP-4053 sodium	DNA/RNA Synthesis Dystrophin	Neurological Disease
Golodirsen (SRP-4053) sodium is an antisense oligonucleotide of the phophorodiamidate morpholino oligomer (PMO). Golodirsen sodium restores the reading frame of the Duchenne muscular dystrophy (DMD) gene by modifying the splicing process of the pre-mRNA, skipping exon 53. Golodirsen sodium can restore the expression of the anti-myostatin protein. Golodirsen sodium can be used for the research of duchenne muscular dystrophy (DMD) .

HY-171179

BD-Oligo	Fluorescent Dye	Neurological Disease
BD-Oligo is an oligomer-specific fluorescent chemical probe. BD-Oligo preferentially identifies Aβ oligomer assemblies over monomers or fibrils by using diversity-directed fluorescent library (DOFL) screening and computational techniques. BD-Oligo exhibits dynamic oligomer monitoring capabilities during Aβ peptide fibril formation as Aβ is induced to form oligomers and ultimately fibrils over time. BD-Oligo also exhibits blood-brain barrier permeability with the ability to stain Aβ oligomers in vivo .

HY-153402

Activated EG3 Tail	Biochemical Assay Reagents Drug Intermediate	Others
Activated EG3 Tail can be used in the synthesis of exon jumping oligomer conjugates .

HY-148913

CS587	CaMK	Neurological Disease
CS587 is a specific inhibitor of CaMK1D with neurocytotoxicity at 10 μM. CS587 modulates the sensitivity of neuronal cells to Aβ oligomer toxicity .

HY-N7699C

D-Pentamannuronic acid	Bacterial	Neurological Disease
D-Pentamannuronic acid, an alginate oligomer, is produced by marine brown algae and by a limited range of Gram negative bacteria. D-Pentamannuronic acid can be used for the research of pain and vascular dementia .

HY-164419A

Atesidorsen sodium COR-004 sodium; ATL1103 sodium; ISIS 227452 sodium	GHR	Others
Atesidorsen sodium is a second-generation, antisense oligomer designed to inhibit translation of human growth hormone receptor (GHR) mRNA

HY-160791A

Claramine TFA	Phosphatase	Infection Cancer
Claramine TFA is a steroidal polyamine. Claramine TFA can regulate the properties of lipid membranes and protect cells from various biological toxins, including misfolded protein oligomers and toxins derived from biological proteins .

HY-12324

SB269652	Dopamine Receptor	Neurological Disease
SB269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R); a new chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology.

HY-160791B

Claramine hydrochloride	Phosphatase	Infection Cancer
Claramine hydrochloride is a steroid polyamine with blood-brain barrier permeability. Claramine hydrochloride can regulate the properties of lipid membranes and protect cells from various biological toxins, including misfolded protein oligomers and biological protein-based toxins .

HY-175840

TAU-IN-5	Tau Protein	Neurological Disease
TAU-IN-5 (compound 13) is a TAU protein inhibitor with an EC50 of 0.81 μM. TAU-IN-5 inhibits the formation of tau (2N4R isoform) oligomers and reduces the formation of tau dimers. TAU-IN-5 can be used in the study of Alzheimer's disease (AD) and Parkinson's disease (PD) .

HY-105067A

Tertomotide hydrochloride GV-1001 hydrochloride	Telomerase	Neurological Disease
Tertomotide (GV1001) hydrochloride is peptide vaccine consists a 16-aa human telomerase reverse transcriptase (hTERT) sequence. Tertomotide hydrochloride shows neuroprotective. Tertomotide hydrochloride has the potential for the research of Alzheimer's disease .

HY-N7699B

D-Tetramannuronic acid	Bacterial	Neurological Disease
D-Tetramannuronic acid, an alginate oligomer, is produced by marine brown algae and by a limited range of Gram negative bacteria. D-Tetramannuronic acid can be used for the research of pain and vascular dementia .

HY-N7699F

D-Octamannuronic acid	Bacterial	Neurological Disease
D-Octamannuronic acid, an alginate oligomer, is produced by marine brown algae and by a limited range of Gram negative bacteria. D-Octamannuronic acid can be used for the research of pain and vascular dementia .

HY-163145

α-Synuclein inhibitor 11	α-synuclein	Neurological Disease
α-Synuclein inhibitor 11 (compound 1) is a selective *α-synuclein (α-syn) oligomer* formation** inhibitor. α-Synuclein inhibitor 11 does not inhibits tau 4R (isoforms 0N4R, 2N4R) or p-tau (isoform 1N4R). α-Synuclein inhibitor 11 can be used for Parkinson's disease (PD) research .

HY-P3780

Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (36-42)	Amyloid-β	Neurological Disease
Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (36-42) is the 36-42 fragment of Amyloid β-Protein. β-amyloid, a polypeptide made up of 36-43 amino acids, is the main component of amyloid plaques found in the brains of people with Alzheimer's disease. β-amyloid oligomers (Aβos) plays A key role in the progression of Alzheimer's disease (AD) by inducing neuronal damage and cognitive impairment .

HY-153405

Activated DPG Subunit	Biochemical Assay Reagents Phosphoramidites	Others
Activated DPG Subunit can be used in the synthesis of exon jumping oligomer conjugates. The oligomer conjugates complement selected target sites in the human anti-muscular atrophy protein gene and induce exon 51 jumping. It can be used for research of muscular dystrophy .

HY-153406

Activated T Subunit	Biochemical Assay Reagents	Others
Activated T Subunit can be used in the synthesis of exon jumping oligomer conjugates. The oligomer conjugates complement selected target sites in the human anti-muscular atrophy protein gene and induce exon 51 jumping. Activated T subunit can be used for research of muscular dystrophy .

HY-N3478

Isohyenanchin Hydroxycoriatin	GABA Receptor	Neurological Disease
Isohyenanchin (Hydroxycoriatin) is an RDLac homo-oligomers antagonist. Isohyenanchin also is a weak antagonist of ionotropic GABA receptors .

HY-139830

Dyrk1A-IN-1	DYRK	Neurological Disease
Dyrk1A-IN-1 is a triple inhibitor of Dyrk1A kinase activity (IC₅₀ = 119 nM) and the aggregation of tau and α-syn oligomers.

HY-P10578

SEN 304	Amyloid-β	Neurological Disease
SEN 304 is an Aβ aggregation inhibitor. SEN 304 can bind directly to Aβ(1-42), delay β-sheet formation and promote aggregation of toxic oligomers into a nontoxic form. SEN 304 can be used for research of Alzheimer’s disease .

HY-P4295

Z-Phe-Ala-diazomethylketone PADK	Cathepsin γ-secretase	Neurological Disease
Z-Phe-Ala-diazomethylketone binds directly to Aβ42 monomers and small oligomers. Z-Phe-Ala-diazomethylketone inhibits the formation of Aβ42 dodecamers and inhibits Aβ42 fibril formation in the solution. Z-Phe-Ala-diazomethylketone has the potential for neurodegenerative disorders research .

HY-P10559

(RXR)4XB	Bacterial	Infection
(RXR)4XB is a cell-penetrating peptide, that binds the phosphorodiamidate morpholino oligomers (PMOs), forms peptide-conjugated PMOs (PPMOs), and improves the delivery of PMO into bacterial cells. (RXR)4XB-PMO conjugate prevents the formation of biofilms, inhibits Pseudomonas aeruginosa with MIC₅₀ of 0.5 to 16 μM, and reduces the bacterial burden in mouse acute pneumonia models .

HY-W206987

2-(Aminomethyl)benzoic acid	Drug Intermediate	Others
2-(Aminomethyl)benzoic acid is an amino acid derivative and also a building block for heterogeneously synthetic folded oligomers with repeating γ/α 2-Amb-Pro motifs. 2-(Aminomethyl)benzoic acid can be used to construct synthetic oligomers .

HY-177854

Aβ aggregation-IN-4	Amyloid-β	Neurological Disease
Aβ aggregation-IN-4 can alleviate the neurotoxicity of amyloid-β protein (Aβ) and significantly reduce the level of oligomeric complexes of Aβ (Aβ-OCs). Aβ aggregation-IN-4 does not decrease the level of amyloid-β protein (Aβ). Aβ aggregation-IN-4 attenuates Aβ oligomerization and prevents oligomer-induced death of primary cortical neurons. Aβ aggregation-IN-4 can be used for the study of Alzheimer’s disease (AD) .

HY-164419

Atesidorsen COR-004; ATL1103; ISIS 227452	GHR	Others
Atesidorsen is a second-generation, antisense oligomer designed to inhibit translation of human growth hormone receptor (GHR) mRNA

HY-P991535

PMN310	Amyloid-β	Neurological Disease
PMN310 is a monoclonal antibody targeting amyloid-β oligomers (AβO). PMN310 prevents AβO-induced memory loss and reduces synaptic loss and inflammation in vivo. PMN310 is potentially useful in Alzheimer's disease research .

HY-P991536

KHK6640	Amyloid-β	Neurological Disease
KHK6640 is a humanized anti-amyloid beta oligomer-specific antibody. KHK6640 demonstrates high potency and efficacy for cognitive improvement in several rodent Alzheimer’s models. KHK6640 can be studied in research for neurological diseases such as Alzheimer’s disease .

HY-121432

Kitol	Drug Metabolite	Others
Kitol is peptide used for after-sun repair cosmetics. The dominant degradation reaction for vitamin A derivatives is heat-induced formation of kitols, i.e., dimers or higher oligomers. Vitamin A esters are used as a model system to evaluate microcalorimetry as a tool for monitoring the stability of heat-sensitive substances .

HY-P10318

SHR-2042	GLP Receptor	Endocrinology
SHR-2042 is a selective agonist of the GLP-1 receptor.SHR-2042 improves glycemic control by activating the GLP-1 receptor, enhancing insulin secretion and inhibiting glucagon secretion. SHR-2042 combined with sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC) promotes monomerization through the formation of micelles and improves oral absorption efficiency .

HY-P10559A

(RXR)4XB TFA	Bacterial	Infection
(RXR)4XB TFA is a cell-penetrating peptide, that binds the phosphorodiamidate morpholino oligomers (PMOs), forms peptide-conjugated PMOs (PPMOs), and improves the delivery of PMO into bacterial cells. (RXR)4XB TFA-PMO conjugate prevents the formation of biofilms, inhibits Pseudomonas aeruginosa with MIC₅₀ of 0.5 to 16 μM, and reduces the bacterial burden in mouse acute pneumonia models .

HY-N0148AR

Rutin hydrate (Standard) Rutoside hydrate (Standard); Quercetin 3-O-rutinoside hydrate (Standard)	Amyloid-β Autophagy Apoptosis Endogenous Metabolite Reference Standards	Neurological Disease Cancer
Rutin (hydrate) (Standard) is the analytical standard of Rutin (hydrate). This product is intended for research and analytical applications. Rutin (Rutoside) hydrate is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin hydrate can cross the blood brain barrier. Rutin hydrate attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

HY-119987

Sudan orange G SOG	Fluorescent Dye	Others
Sudan orange G is an azo dye. Sudan orange G, after enzymatic oxidation, generates oligomers and even polymers through free radical coupling reactions .

Cat. No.	Nombre del producto	Type

HY-171179

BD-Oligo

Fluorescent Dyes

BD-Oligo is an oligomer-specific fluorescent chemical probe. BD-Oligo preferentially identifies Aβ oligomer assemblies over monomers or fibrils by using diversity-directed fluorescent library (DOFL) screening and computational techniques. BD-Oligo exhibits dynamic oligomer monitoring capabilities during Aβ peptide fibril formation as Aβ is induced to form oligomers and ultimately fibrils over time. BD-Oligo also exhibits blood-brain barrier permeability with the ability to stain Aβ oligomers in vivo .

HY-119987

Sudan orange G SOG	Fluorescent Dyes
Sudan orange G is an azo dye. Sudan orange G, after enzymatic oxidation, generates oligomers and even polymers through free radical coupling reactions .

HY-119987R

Sudan orange G (Standard) SOG (Standard)	Fluorescent Dyes
Sudan orange G (Standard) is the analytical standard of Sudan orange G. This product is intended for research and analytical applications. Sudan orange G is an azo dye. Sudan orange G, after enzymatic oxidation, generates oligomers and even polymers through free radical coupling reactions .

HY-D3220

PTO-41	Fluorescent Dyes
PTO-41 is a blood-brain barrier-permeable near-infrared fluorescent probe that targets β-amyloid oligomers (*Aβ Oligomers, AβOs) with a K_d* of 349 nM. PTO-41 exhibits low cytotoxicity, high sensitivity to β-amyloid oligomers in in vitro phantom imaging, and can be rapidly cleared from the brain. PTO-41 is applicable to the research of Alzheimer's disease (Ex/Em = 538 nM/680 nM) .

Cat. No.	Nombre del producto	Type

HY-D0874

HEPPSO

Biochemical Assay Reagents

HEPPSO is a zwitterionic Good's buffer suitable for physiological pH conditions. HEPPSO forms high-order oligomers in aqueous solutions and can form a 1:1 complex with Cu ²⁺ via its hydroxyalkyl and tertiary amine groups. However, HEPPSO contains a structurally similar trace impurity lacking an alkanesulfonic acid side chain. The complex formed by this impurity and Cu ²⁺ has a very low Ka; therefore, HEPPSO may interfere with studies on copper speciation analysis in natural water bodies .

Cat. No.	Nombre del producto	Target	Research Area

HY-P1363

β-Amyloid (1-42), human TFA Maximum Cited Publications 24 Publications Verification Amyloid β-peptide (1-42) (human) TFA	Amyloid-β	Neurological Disease
β-Amyloid (1-42) (Amyloid β-peptide (1-42), human TFA, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human TFA remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human TFA, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, *can form soluble oligomers* (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity*; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers* bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

HY-P1363A

β-Amyloid (1-42), human Maximum Cited Publications 24 Publications Verification Amyloid β-peptide (1-42) (human)	Amyloid-β	Neurological Disease
β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, *can form soluble oligomers* (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity*; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers* bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

HY-P1363B

β-Amyloid (1-42), human, HFIP-treated Maximum Cited Publications 24 Publications Verification	Amyloid-β	Neurological Disease
β-Amyloid (1-42), human, HFIP-treated, a 42-amino acid peptide that has been treated with HFIP from β-Amyloid (1-42), human (HY-P1363A), is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human, HFIP-treated remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, HFIP-treated, after being dissolved in DMSO to form the stock solution, on the one hand, *can form soluble oligomers* (AβOs) when incubated at 4°C, which have synaptic toxicity and neurotoxicity*; on the other hand, it can be incubated at 37°C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers* bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

HY-P2031

Phallacidin	Arp2/3 Complex	Others
Phallacidin is a natural bicyclic heptapeptide derived from the poisonous mushroom Amanita phalloides. Phallacidin binds to filamentous actin specifically with high affinity, with a K_d of 20 nM. After binding to F-actin, Phallacidin strongly inhibits its depolymerization, stabilizes microfilament structures, and prevents their disruption by drugs such as cytochalasins. When conjugated with a fluorophore, Phallacidin serves as a specific fluorescent probe for F-actin, which is used to clearly visualize the distribution of actin in the cytoskeleton (e.g., stress fibers, cortical peripheral bands) under fluorescence microscopy .

HY-P2288A

WL47 TFA 3 Publications Verification	Peptides	Cancer
WL47 TFA, a high-affinity cavolin-1 (CAV1) ligand (K_d=23 nM), is a potent disrupter of CAV1 oligomers. WL47 TFA shows selectivity for CAV1 over BSA, casein and HEWL. WL47 TFA is 80% smaller in length than the original T20 (HY-P0052) parent sequence and can be used for the study of caveolin-1 function .

HY-P5905

Citrullinated amyloid-β (1-42) peptide (human) Citrullinated Aβ (1-42); Citrullinated Aβ42	Amyloid-β	Neurological Disease
Citrullinated amyloid-β (1-42) peptide (human) (Citrullinated Aβ (1-42)) is a modified form of β-Amyloid (1-42) (HY-P1363) with a citrullination at the Arg5 site. Compared to the unmodified β-Amyloid (1-42), its formation of soluble low-molecular-weight oligomers is enhanced, the rate of fibril formation is reduced, and like unmodified Aβ42, it forms protofibrils comprised of parallel β-sheets .

HY-P3780

Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (36-42)	Amyloid-β	Neurological Disease
Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (36-42) is the 36-42 fragment of Amyloid β-Protein. β-amyloid, a polypeptide made up of 36-43 amino acids, is the main component of amyloid plaques found in the brains of people with Alzheimer's disease. β-amyloid oligomers (Aβos) plays A key role in the progression of Alzheimer's disease (AD) by inducing neuronal damage and cognitive impairment .

HY-P10578

SEN 304	Amyloid-β	Neurological Disease
SEN 304 is an Aβ aggregation inhibitor. SEN 304 can bind directly to Aβ(1-42), delay β-sheet formation and promote aggregation of toxic oligomers into a nontoxic form. SEN 304 can be used for research of Alzheimer’s disease .

HY-P4295

Z-Phe-Ala-diazomethylketone PADK	Cathepsin γ-secretase	Neurological Disease
Z-Phe-Ala-diazomethylketone binds directly to Aβ42 monomers and small oligomers. Z-Phe-Ala-diazomethylketone inhibits the formation of Aβ42 dodecamers and inhibits Aβ42 fibril formation in the solution. Z-Phe-Ala-diazomethylketone has the potential for neurodegenerative disorders research .

HY-P10559

(RXR)4XB	Bacterial	Infection
(RXR)4XB is a cell-penetrating peptide, that binds the phosphorodiamidate morpholino oligomers (PMOs), forms peptide-conjugated PMOs (PPMOs), and improves the delivery of PMO into bacterial cells. (RXR)4XB-PMO conjugate prevents the formation of biofilms, inhibits Pseudomonas aeruginosa with MIC₅₀ of 0.5 to 16 μM, and reduces the bacterial burden in mouse acute pneumonia models .

HY-P10567

Pip6a	Peptides	Others
Pip6a is an arginine-rich cell-penetrating peptide. Pip6a has the ability to deliver associated cargoes across the plasma and endosomal membranes and is stable to serum proteolysis. Pip6a is composed of a hydrophobic core region flanked on each side by arginine-rich domains containing β-alanine and aminohexanoyl spacers. Pip6a-conjugated morpholino phosphorodiamidate oligomer (PMO) dramatically enhanced antisense oligonucleotide (ASO) delivery into striated muscles of myotonic dystrophy (DM1) mice .

HY-P10318

SHR-2042	GLP Receptor	Endocrinology
SHR-2042 is a selective agonist of the GLP-1 receptor.SHR-2042 improves glycemic control by activating the GLP-1 receptor, enhancing insulin secretion and inhibiting glucagon secretion. SHR-2042 combined with sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC) promotes monomerization through the formation of micelles and improves oral absorption efficiency .

HY-P10559A

(RXR)4XB TFA	Bacterial	Infection
(RXR)4XB TFA is a cell-penetrating peptide, that binds the phosphorodiamidate morpholino oligomers (PMOs), forms peptide-conjugated PMOs (PPMOs), and improves the delivery of PMO into bacterial cells. (RXR)4XB TFA-PMO conjugate prevents the formation of biofilms, inhibits Pseudomonas aeruginosa with MIC₅₀ of 0.5 to 16 μM, and reduces the bacterial burden in mouse acute pneumonia models .

HY-P1363S1

β-Amyloid (1-42), human, Ala(13C3,15N) TFA	Isotope-Labeled Compounds Amyloid-β	Neurological Disease
β-Amyloid (1-42), human, Ala( ¹³C₃, ¹⁵N) TFA is the ¹³C and ¹⁵N-labeled β-Amyloid (1-42), human (HY-P1363A). β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, *can form soluble oligomers* (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity*; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers* bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

HY-P2288

WL47	Peptides	Cancer
WL47, a high-affinity cavolin-1 (CAV1) ligand (K_d=23 nM), is a potent disrupter of CAV1 oligomers. WL47 shows selectivity for CAV1 over BSA, casein and HEWL. WL47 is 80% smaller in length than the original T20 (HY-P0052) parent sequence and can be used for the study of caveolin-1 function .

HY-P10630

Pep63	Amyloid-β	Neurological Disease
Pep63 is a neuroprotective peptide (VFQVRARTVA). Pep63 has a neuroprotective effect on synaptic plasticity and memory. Pep63 can competitively bind with Aβ1-42 oligomers, and can block Aβ fiber formation. Pep63 can be used for Alzheimer’s disease (AD) research .

HY-P3781

(Met(O)35)-Amyloid β-Protein (1-42)	Amyloid-β	Neurological Disease
(Met(O)35)-Amyloid β-Protein (1-42) is the oxidation form of Met35 in Aβ42. (Met(O)35)-Amyloid β-Protein (1-42) can yield an oligomer size distribution characteristic of Aβ40. (Met(O)35)-Amyloid β-Protein (1-42) can be used in the research of Alzheimer’s disease (AD) .

HY-P10565

(RFR)4XB	Bacterial	Infection
(RFR)4XB is a cationic membrane-penetrating peptide. (RFR)4XB carries its cargo (the antisense oligomer) across the outer membrane of gram-negative bacteria .

HY-P10876

mcK6A1	Amyloid-β	Neurological Disease
mcK6A1 is an inhibitor for the aggregation of amyloid-β (Aβ), that selectively binds to the 16KLVFFA21 segment of Aβ42, forms an extended β-folded structure, and inhibits the formation of Aβ42 oligomers. mcK6A1 can be used in research of Alzheimer's disease and other amyloid-related diseases .

HY-P5368

[Arg6]-β-Amyloid (1-40), england mutation	Peptides	Others
[Arg6]-β-Amyloid (1-40), england mutation is a biological active peptide. (Several mutations in the beta amyloid precursor gene cause autosomal dominant Alzheimer's Disease in a number of kindreds. Among them, the English mutation, with His at position 6 replaced with Arg, was reported to accelerate the kinetics of oligomers formation which act as fibril seeds and are more toxic to cultured neuronal cells.)

HY-P5906

Citrullinated amyloid-β (1-40) peptide (human) Citrullinated Aβ (1-40); Citrullinated Aβ40	Amyloid-β	Neurological Disease
Citrullinated amyloid-β (1-40) peptide (human) (Citrullinated Aβ (1-40)) is a modified form of β-Amyloid (1-40) (HY-P0265) with a citrullination at the Arg5 site. Citrullinated amyloid-β (1-40) peptide (human) exhibits increased transient formation of soluble oligomers and insoluble aggregates composed of distorted parallel β-sheets compared with unmodified β-Amyloid (1-40) .

HY-P10035

β Amyloid(28-35) human	Amyloid-β	Neurological Disease
β Amyloid(28-35) human is a β-amyloid peptide (Abeta), a lipid-induced amyloid core fragment. β Amyloid oligomers are neurotoxic, and β Amyloid(28-35) human can interact with neuronal membranes, regulate secondary structure and neurotoxicity, and cause Alzheimer's disease. β Amyloid(28-35) human has anisotropic effects on the acidic phospholipid DPH, resulting in enhanced internal fluidity of lipid membrane bilayers .

HY-W784625

Boc-PNA-G(Z)-OH	Drug Intermediate	Others
Boc-PNA-G(Z)-OH is a peptide nucleic acid (PNA) monomer that is used for the synthesis of peptide nucleic acid oligomers .

HY-W871908

Boc-Aeg(Fmoc)-OH	Biochemical Assay Reagents	Others
Boc-Aeg(Fmoc)-OH is a Boc/Fmoc-protected 2-aminoethylglycine building block. Boc-Aeg(Fmoc)-OH facilitates solid-phase synthesis of acridine oligomers with a (2-aminoethyl)glycine backbone .

HY-P10332

WL 47 dimer	Peptides	Others
WL 47 dimer (ligand 1) is a caveolin-1 (CAV-1) ligand with high affinity, selectivity and oligomer dissociation activity. WL 47 dimer simultaneously occupies two binding sites of CAV-1, inducing the dissociation of oligomers. WL 47 dimer has 7500-fold improved affinity compared to its T20 parent ligand and an 80% decrease in sequence length. WL 47 dimer can be used to permit targeted study of CAV-1 function .

HY-P11689

Fmoc-PNA-J(Bhoc)-OH	Biochemical Assay Reagents	Others
Fmoc-PNA-J (Bhoc)-OH is a protected peptide nucleic acid (PNA) monomer building block used for solid-phase synthesis of PNA oligomers. Fmoc-PNA-J (Bhoc)-OH carries Fmoc/Bhoc protecting groups and functions as a standard Fmoc-protected PNA monomer .

HY-P11691

Fmoc-PNA-D(tetraBoc)-OH	Biochemical Assay Reagents	Others
Fmoc-PNA-D (tetraBoc)-OH is an Fmoc/Boc-protected diaminopurine peptide nucleic acid (PNA) monomer suitable for standard Fmoc solid-phase synthesis. Fmoc-PNA-D (tetraBoc)-OH carries Boc-protected exocyclic amino groups and can be incorporated into pseudo-complementary PNA oligomers for applications in antigenic peptide nucleic acid and DNA nanotechnology research .

HY-W415169

H-Aeg(Fmoc)-OBzl hydrochloride	Drug Intermediate	Others
H-Aeg(Fmoc)-OBzl hydrochloride is an Fmoc-protected aminoethylglycine derivative with benzyl ester and can be used for synthesis of peptide nucleic acid and protected oligomers.

HY-P11679

Boc-PNA-U-OH	DNA/RNA Synthesis	Others
Boc-PNA-U-OH is a protected peptide nucleic acid (PNA) monomer containing a uracil base, designed for solid-phase peptide synthesis (SPPS) using the Boc/Z protection strategy. Boc-PNA-U-OH acts as a building block in creating PNA oligomers that are neutral, stable, and used for antisense/antigene applications.

HY-P11682

Boc-PNA-M(Z)-OH	DNA/RNA Synthesis	Others
Boc-PNA-M(Z)-OH is a protected peptide nucleic acid (PNA) monomer used in solid-phase peptide synthesis (SPPS). Boc-PNA-M(Z)-OH consists of an adenyl base protected with a benzyloxycarbonyl (Z) group and a backbone protected with a tert-butyloxycarbonyl (Boc) group, typically used for creating PNA oligomers.

Cat. No.	Nombre del producto	Target	Research Area	Image

HY-P991413

ZEB85	Trk Receptor ERK Akt p38 MAPK	Neurological Disease Inflammation/Immunology
ZEB85 is a human monoclonal antibody (mAb) targeting TrkB. ZEB85 activates TrkB and its downstream cascades, including the ERK, PLCγ, AKT, MAPK signaling pathways and cFOS expression, and enhances neuronal activity. ZEB85 prevents β-amyloid toxicity in cultured hippocampal neurons. ZEB85 is applicable to the research of Alzheimer's disease (AD) .

HY-P990081

Oloctinebart TB-006	Inhibitory Antibodies	Neurological Disease
Oloctinebart is a humanized immunoglobulin G4-kappa, anti-LGALS3 monoclonal antibody. Oloctinebart is used for reduction of amyloid beta oligomers formation .

HY-P991535

PMN310	Amyloid-β	Neurological Disease
PMN310 is a monoclonal antibody targeting amyloid-β oligomers (AβO). PMN310 prevents AβO-induced memory loss and reduces synaptic loss and inflammation in vivo. PMN310 is potentially useful in Alzheimer's disease research .

HY-P991536

KHK6640	Amyloid-β	Neurological Disease
KHK6640 is a humanized anti-amyloid beta oligomer-specific antibody. KHK6640 demonstrates high potency and efficacy for cognitive improvement in several rodent Alzheimer’s models. KHK6640 can be studied in research for neurological diseases such as Alzheimer’s disease .

HY-P991654

SAR228810	Amyloid-β	Neurological Disease
SAR228810 is a humanized IgG4 monoclonal antibody inhibitor targeting amyloid β (Aβ) with a KD? of ?0.43 ?nM for protofibrillar Aβ over monomeric Aβ. SAR228810 significantly inhibits the brain amyloid plaque formation and oligomer-induced synaptic dysfunction and neurite loss. SAR228810 has significant protection against Aβ-mediated neuritotoxicity. MINT1526A can be used for Alzheimer’s disease imaging and immunotherapy research .

HY-P991073

MEDI-1814	Amyloid-β	Neurological Disease
MEDI-1814 is a fully human IgG1 antibody that targets the C terminus of Aβ42. MEDI-1814 binds to and sweeps away the circulated Aβ peptides, hence, restricting them from aggregating into toxic oligomers. MEDI-1814 can be used for the study of Alzheimer's diseases. The isotype control for MEDI-1814 can refer to Human IgG1 kappa, Isotype Control (HY-P99001) .

Cat. No.	Nombre del producto	Category	Target	Chemical Structure

HY-N0148

Rutin Maximum Cited Publications 30 Publications Verification Rutoside; Quercetin 3-O-rutinoside	Flavonols Classification of Application Fields Plants Flavonoids other families Leguminosae Sunscreen Phenols Polyphenols Cosmetic Research Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification Cancer	Amyloid-β Autophagy Apoptosis Endogenous Metabolite
Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a CBR1 inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

HY-N0148A

Rutin hydrate Maximum Cited Publications 30 Publications Verification Rutoside hydrate; Quercetin 3-O-rutinoside hydrate	Flavonols Flavonoids other families Phenols Polyphenols Plants Source Classification	Amyloid-β Autophagy Apoptosis Endogenous Metabolite
Rutin (Rutoside) hydrate is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin hydrate can cross the blood brain barrier. Rutin hydrate attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

HY-N2581

Phytic acid sodium salt 1 Publications Verification myo-Inositol, hexakisdihydrogen phosphate sodium salt; Inositol hexaphosphate sodium salt	Structural Classification Productos naturales Zea mays L. Classification of Application Fields Gramineae Other Diseases Plants Disease Research Fields Source Classification	MOFs Endogenous Metabolite Amyloid-β Autophagy
Phytic acid (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) sodium salt is an orally active compound. Phytic acid sodium salt can be derived from the seeds of legumes. Phytic acid sodium salt is a [PO4] ³- storage depot and precursor for other inositol phosphates and pyrophosphates. Phytic acid sodium salt attenuates Aβ oligomers and upregulates autophagy protein. Phytic acid sodium salt can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research .

HY-112108

Chitosan oligosaccharide 5 Publications Verification COS	Polysaccharides Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Source Classification Cancer	AMPK Endogenous Metabolite
Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. Chitosan oligosaccharide (COS) activates AMPK and inhibits inflammatory signaling pathways including NF-κB and MAPK pathways.

HY-N0814

Phytic acid (50% w/w in water) 1 Publications Verification Inositol hexaphosphate; SNF472 free acid	Structural Classification other families Neurological Disease Classification of Application Fields Food Preservation Research Ketones, Aldehydes, Acids Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification Agricultural Research	Endogenous Metabolite Amyloid-β Autophagy
Phytic acid (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) is an orally active compound. Phytic acid can be derived from the seeds of legumes. Phytic acid is a [PO4] ³- storage depot and precursor for other inositol phosphates and pyrophosphates. Phytic acid attenuates Aβ oligomers and upregulates autophagy protein. Phytic acid can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research .

HY-N12060

Ginkgo biloba extract	Structural Classification Productos naturales Ginkgoaceae Plants Ginkgo biloba Source Classification	Bcl-2 Family Caspase Apoptosis Autophagy Reactive Oxygen Species (ROS) Akt JNK ERK
Ginkgo biloba extract is a natural product that can be isolated from Ginkgo biloba leaves . Ginkgo biloba extract alleviates oxidative stress-induced neuronal apoptosis (Apoptosis) by stabilizing mitochondrial function, regulating Bcl-2 family proteins and inhibiting caspase activation. Ginkgo biloba extract alleviates testicular injury by upregulating SKP2 and inhibiting Beclin1-independent autophagy (Autophagy) . Ginkgo biloba extract alleviates various types of neuronal damage in animal models. Ginkgo biloba extract reduces behavioral sensitization in rats. Ginkgo biloba extract counteracts Aβ-induced neurotoxicity by blocking a series of Aβ-triggered events, including glucose uptake, ROS accumulation, AKT activation, mitochondrial dysfunction, JNK and ERK 1/2 pathways, and apoptosis, and also interferes with the formation of Aβ oligomers. Ginkgo biloba extract is applicable to research related to cerebral hypoperfusion, testicular injury, Alzheimer's disease, Parkinson's disease, multi-infarct dementia, stroke, traumatic brain injury and amyotrophic lateral sclerosis .

HY-N0148R

Rutin (Standard) Rutoside (Standard); Quercetin 3-O-rutinoside (Standard)	Flavonols Structural Classification Flavonoids other families Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Source Classification	Reference Standards Amyloid-β Autophagy Apoptosis Endogenous Metabolite
Rutin (Standard) is the analytical standard of Rutin. This product is intended for research and analytical applications. Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a CBR1 inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

HY-W010041

Scyllo-Inositol	Productos naturales Endogenous metabolite Source Classification	α-synuclein Amyloid-β
Scyllo-Inositol is an inhibitor that targets the aggregation of misfolded proteins (such as α-synuclein and Amyloid-β), is orally effective, and can cross the blood-brain barrier. Scyllo-Inositol can selectively bind to and stabilize non-toxic oligomers, preventing them from converting into toxic fibers, exerting protein homeostasis regulation and neuroprotective activity. Scyllo-Inositol binds to the hydrophobic region of pathogenic proteins, inhibits protein aggregation, and promotes lysosome- and proteasome-mediated degradation pathways, thereby reducing neurotoxicity. Scyllo-Inositol can be used in the study of neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and Huntington's disease .

HY-N7697

Chitotetraose tetrahydrochloride	Structural Classification Polysaccharides Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Saccharides Source Classification	Others
Chitotetraose tetrahydrochloride is a short-chain chitin oligomer derived from arbuscular mycorrhizal (AM) fungi. Chitotetraose tetrahydrochloride activates the AM fungus-dependent conserved symbiotic signaling pathway (CSSP) in actinorhizal plant species .

HY-N2048

2,2':5',2''-Terthiophene α-Terthiophene; α-Terthienyl; Trithiophene	Infection Structural Classification Productos naturales Classification of Application Fields Erythrina melanacantha Taub. ex Harms Plants Compositae Disease Research Fields Source Classification	Environmental Pollutants Antibiotic Bacterial
2,2':5',2''-Terthiophene (α-Terthiophene) is an oligomer of the heterocycle thiophene. 2,2':5',2''-Terthiophene has been employed as building block for the organic semi-conductor polythiophene.

HY-P2031

Phallacidin	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Disease Research Fields Source Classification	Arp2/3 Complex
Phallacidin is a natural bicyclic heptapeptide derived from the poisonous mushroom Amanita phalloides. Phallacidin binds to filamentous actin specifically with high affinity, with a K_d of 20 nM. After binding to F-actin, Phallacidin strongly inhibits its depolymerization, stabilizes microfilament structures, and prevents their disruption by drugs such as cytochalasins. When conjugated with a fluorophore, Phallacidin serves as a specific fluorescent probe for F-actin, which is used to clearly visualize the distribution of actin in the cytoskeleton (e.g., stress fibers, cortical peripheral bands) under fluorescence microscopy .

HY-N2580

Zinc Phytate 1 Publications Verification	Productos naturales other families Classification of Application Fields Other Diseases Plants Disease Research Fields Source Classification	Endogenous Metabolite Amyloid-β Autophagy
Zinc Phytate (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) is an orally active compound. Zinc Phytate can be derived from the seeds of legumes. Zinc Phytate is a [PO4] ³- storage depot and precursor for other inositol phosphates and pyrophosphates. Zinc Phytate attenuates Aβ oligomers and upregulates autophagy protein. Zinc Phytate can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research .

HY-N7699C

D-Pentamannuronic acid	Polysaccharides Microorganisms Neurological Disease Classification of Application Fields Marine algae Marine natural products Disease Research Fields Saccharides	Bacterial
D-Pentamannuronic acid, an alginate oligomer, is produced by marine brown algae and by a limited range of Gram negative bacteria. D-Pentamannuronic acid can be used for the research of pain and vascular dementia .

HY-N7699B

D-Tetramannuronic acid	Polysaccharides other families Neurological Disease Classification of Application Fields Marine algae Marine natural products Plants Disease Research Fields Saccharides Source Classification	Bacterial
D-Tetramannuronic acid, an alginate oligomer, is produced by marine brown algae and by a limited range of Gram negative bacteria. D-Tetramannuronic acid can be used for the research of pain and vascular dementia .

HY-N7699F

D-Octamannuronic acid	Structural Classification Polysaccharides Microorganisms Neurological Disease Classification of Application Fields Marine algae Marine natural products Disease Research Fields Saccharides	Bacterial
D-Octamannuronic acid, an alginate oligomer, is produced by marine brown algae and by a limited range of Gram negative bacteria. D-Octamannuronic acid can be used for the research of pain and vascular dementia .

HY-N3478

Isohyenanchin Hydroxycoriatin	Terpenoids Sesquiterpenes Campanulaceae Campanula medium L. Plants Source Classification	GABA Receptor
Isohyenanchin (Hydroxycoriatin) is an RDLac homo-oligomers antagonist. Isohyenanchin also is a weak antagonist of ionotropic GABA receptors .

HY-N0148AR

Rutin hydrate (Standard) Rutoside hydrate (Standard); Quercetin 3-O-rutinoside hydrate (Standard)	Flavonols Structural Classification Flavonoids other families Phenols Polyphenols Plants Source Classification	Amyloid-β Autophagy Apoptosis Endogenous Metabolite Reference Standards
Rutin (hydrate) (Standard) is the analytical standard of Rutin (hydrate). This product is intended for research and analytical applications. Rutin (Rutoside) hydrate is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin hydrate can cross the blood brain barrier. Rutin hydrate attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

HY-N7699A

D-Trimannuronic acid	Polysaccharides other families Plants Saccharides Source Classification	TNF Receptor
D-Trimannuronic acid, an alginate oligomer is extracted from seaweed. D-Trimannuronic acid can induce TNF‐α secretion by mouse macrophage cell lines. D-Trimannuronic acid can be used for the research of pain and vascular dementia .

HY-N7699E

D-Heptamannuronic acid	Polysaccharides Microorganisms Neurological Disease Classification of Application Fields Marine algae Marine natural products Disease Research Fields Saccharides	Bacterial
D-Heptamannuronic acid, an alginate oligomer, is produced by marine brown algae and by a limited range of Gram negative bacteria. D-Heptamannuronic acid can be used for the research of pain and vascular dementia .

HY-N7699G

D-Nonamannuronic acid	Structural Classification Polysaccharides Microorganisms Neurological Disease Classification of Application Fields Marine algae Marine natural products Disease Research Fields Saccharides	Bacterial
D-Nonamannuronic acid, an alginate oligomer, is produced by marine brown algae and by a limited range of Gram negative bacteria. D-Nonamannuronic acid can be used for the research of pain and vascular dementia .

HY-N7699D

D-Hexamannuronic acid	Polysaccharides Microorganisms Neurological Disease Classification of Application Fields Marine algae Marine natural products Disease Research Fields Saccharides	Bacterial
D-Hexamannuronic acid, an alginate oligomer, is produced by marine brown algae and by a limited range of Gram negative bacteria. D-Hexamannuronic acid can be used for the research of pain and vascular dementia .

HY-N6640

2-O-Acetyl-20-hydroxyecdysone 20-Hydroxyeedysone 2-acetate	other families Plants Steroids Source Classification	Amyloid-β
2-O-Acetyl-20-hydroxyecdysone, an ecdysterones in insects and terrestrial plants, inhibits amyloid-β₄₂ (Aβ₄₂)-induced cytotoxicity. 2-O-Acetyl-20-hydroxyecdysone could decrease Aβ oligomer formation through promotion of fibrogenesis, transforming Aβ oligomers to the low-toxicity fibrils .

HY-N7697R

Chitotetraose tetrahydrochloride (Standard)	Structural Classification Polysaccharides Microorganisms Saccharides Source Classification	Reference Standards Others
Butylate (Standard) is the analytical standard of Butylate. This product is intended for research and analytical applications. Butylate is a compound involved in platelet research. Platelet activation can cause autophagy, which is partly mediated by the AMPK-MTOR pathway and is related to sphingolipid metabolism. Butylate mentioned in the study may be a tool or control substance for studying related metabolic processes.

HY-N2048R

2,2':5',2''-Terthiophene (Standard) α-Terthiophene (Standard); α-Terthienyl (Standard); Trithiophene (Standard)	Structural Classification Productos naturales Erythrina melanacantha Taub. ex Harms Plants Compositae Source Classification	Reference Standards Bacterial Antibiotic
2,2':5',2''-Terthiophene (Standard) is the analytical standard of 2,2':5',2''-Terthiophene. This product is intended for research and analytical applications. 2,2':5',2''-Terthiophene (α-Terthiophene) is an oligomer of the heterocycle thiophene. 2,2':5',2''-Terthiophene has been employed as building block for the organic semi-conductor polythiophene.

HY-W010041R

Scyllo-Inositol (Standard)	Structural Classification Productos naturales Endogenous metabolite Source Classification	Reference Standards α-synuclein Amyloid-β
Scyllo-Inositol is an inhibitor that targets the aggregation of misfolded proteins (such as α-synuclein and Amyloid-β), is orally effective, and can cross the blood-brain barrier. Scyllo-Inositol can selectively bind to and stabilize non-toxic oligomers, preventing them from converting into toxic fibers, exerting protein homeostasis regulation and neuroprotective activity. Scyllo-Inositol binds to the hydrophobic region of pathogenic proteins, inhibits protein aggregation, and promotes lysosome- and proteasome-mediated degradation pathways, thereby reducing neurotoxicity. Scyllo-Inositol can be used in the study of neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and Huntington's disease .

HY-N18076

Nordracorubin	Structural Classification Flavonoids Flavones Arecaceae Daemonorops jenkinsiana(Griff.) Mart. Plants Source Classification	Others
Nordracorubin is a flavonoid oligomer present in Daemonorops draco. Nordracorubin can be used in the research of Alzheimer's disease and cancer .

HY-N17929

Doliroside A	Structural Classification Tetracyclic Triterpenoids Leguminosae Terpenoids Plants Dolichos trilobus Houtt. Source Classification	Amyloid-β
Doliroside A is an Aβ42-binding agent with an IC₅₀ of 26.57 μM for Aβ42. Doliroside A binds to Aβ42 nuclei and oligomers to form stable complexes, suppresses Aβ42 fibrillation, and redirects Aβ42 into off-pathway, amorphous oligomers. Doliroside A can be used for the research of alzheimer’s disease (ad) .

HY-N7970

Parthenocissin A	Structural Classification Phenols Polyphenols Parthenocissus quinquefolia (L.) Planch. Plants Vitaceae Source Classification	Others
Parthenocissin A is a resveratrol oligomer found in the stem of Parthenocissus quinquefolia .

HY-W720917

Junicedric acid	Structural Classification Pinaceae Terpenoids Diterpenoids Plants Pinus merkusii Jungh. & de Vriese Source Classification	CaMK PKC Amyloid-β Apoptosis
Junicedric acid is a diterpenoid compound that can be isolated from the resin of the Araucaria araucana tree. Junicedric acid exerts neuroprotective activity by increasing intracellular calcium levels in hippocampal neurons, activating PKC and calcium/calmodulin-dependent protein kinase (CaMKII), and preventing Amyloid-β oligomer-induced synaptic protein loss, apoptosis, and long-term potentiation (LTP) inhibition. Junicedric acid can be used in the study of the pathological mechanisms of neurodegenerative diseases such as Alzheimer's disease .

Cat. No.	Nombre del producto	Chemical Structure

HY-P1363S1

β-Amyloid (1-42), human, Ala(13C3,15N) TFA

β-Amyloid (1-42), human, Ala( ¹³C₃, ¹⁵N) TFA is the ¹³C and ¹⁵N-labeled β-Amyloid (1-42), human (HY-P1363A). β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

HY-117259S

Valiltramiprosate-d6

Valiltramiprosate-d₆ (ALZ-801-d₆) is deuterium labeled Valiltramiprosate. ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound . ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease .

HY-W707693

Scyllo-Inositol-d6

Scyllo-Inositol-d₆ is the deuterium labeled Scyllo-Inositol (HY-W010041). Scyllo-Inositol is an inhibitor that targets the aggregation of misfolded proteins (such as α-synuclein and Amyloid-β), is orally effective, and can cross the blood-brain barrier. Scyllo-Inositol can selectively bind to and stabilize non-toxic oligomers, preventing them from converting into toxic fibers, exerting protein homeostasis regulation and neuroprotective activity. Scyllo-Inositol binds to the hydrophobic region of pathogenic proteins, inhibits protein aggregation, and promotes lysosome- and proteasome-mediated degradation pathways, thereby reducing neurotoxicity. Scyllo-Inositol can be used in the study of neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and Huntington's disease .

Cat. No.	Nombre del producto		Classification

HY-Y1230

4-Pentynoic acid Propargylacetic acid		Alkynes
4-Pentynoic acid (Propargylacetic acid) is an intermediate to produce biologically active compounds. 4-Pentynoic acid is widely utilized as a building block for the synthesis of eight sequence-defined model oligomers . 4-Pentynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Nombre del producto		Classification

HY-132611

Golodirsen SRP-4053		Antisense Oligonucleotides
Golodirsen (SRP-4053) is an antisense oligonucleotide of the phophorodiamidate morpholino oligomer (PMO). Golodirsen restores the reading frame of the Duchenne muscular dystrophy (DMD) gene by modifying the splicing process of the pre-mRNA, skipping exon 53. Golodirsen can restore the expression of the anti-myostatin protein. Golodirsen can be used for the research of duchenne muscular dystrophy (DMD) .

HY-132611A

Golodirsen sodium SRP-4053 sodium		Antisense Oligonucleotides
Golodirsen (SRP-4053) sodium is an antisense oligonucleotide of the phophorodiamidate morpholino oligomer (PMO). Golodirsen sodium restores the reading frame of the Duchenne muscular dystrophy (DMD) gene by modifying the splicing process of the pre-mRNA, skipping exon 53. Golodirsen sodium can restore the expression of the anti-myostatin protein. Golodirsen sodium can be used for the research of duchenne muscular dystrophy (DMD) .

HY-164419A

Atesidorsen sodium COR-004 sodium; ATL1103 sodium; ISIS 227452 sodium		Antisense Oligonucleotides
Atesidorsen sodium is a second-generation, antisense oligomer designed to inhibit translation of human growth hormone receptor (GHR) mRNA

HY-132585A

Vesleteplirsen sodium SRP-5051 sodium		Antisense Oligonucleotides
Vesleteplirsen (SRP-5051) sodium is a next-generation antisense oligonucleotide of peptide phosphorodiamidate morpholino oligomer (PPMO). Vesleteplirsen targets exon 51 skipping in Duchenne muscular dystrophy (DMD) .

HY-153405

Activated DPG Subunit		Phosphoramidites Other Phosphoramidite
Activated DPG Subunit can be used in the synthesis of exon jumping oligomer conjugates. The oligomer conjugates complement selected target sites in the human anti-muscular atrophy protein gene and induce exon 51 jumping. It can be used for research of muscular dystrophy .

HY-164419

Atesidorsen COR-004; ATL1103; ISIS 227452		Antisense Oligonucleotides
Atesidorsen is a second-generation, antisense oligomer designed to inhibit translation of human growth hormone receptor (GHR) mRNA

HY-153404

Activated C Subunit		Phosphoramidites Other Phosphoramidite
Activated C Subunit can be used in the synthesis of exon jumping oligomer conjugates. The oligomer conjugates complement selected target sites in the human anti-muscular atrophy protein gene and induce exon 51 jumping. It can be used for research of muscular dystrophy .

HY-148828

LSP-GR3		Antisense Oligonucleotides
LSP-GR3 is a novel chemically-modified RNA oligonucleotides, called splice modulating oligomers (SMOs), which potently and specifically modulate GluR alternative splicing to GluR3-flip expression throughout the CNS.

HY-148828A

LSP-GR3 sodium		Antisense Oligonucleotides
LSP-GR3 sodium is a novel chemically-modified RNA oligonucleotides, called splice modulating oligomers (SMOs), which potently and specifically modulate GluR alternative splicing to GluR3-flip expression throughout the CNS.

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