1. PI3K/Akt/mTOR
    Stem Cell/Wnt
    Neuronal Signaling
  2. GSK-3
    Amyloid-β
  3. Cu(II)GTSM

Cu(II)GTSM 

Cat. No.: HY-139324
Handling Instructions

Cu(II)GTSM, a cell-permeable Cu-complex, significantly inhibits GSK3β. Cu(II)GTSM inhibits Amyloid-β oligomers (AβOs) and decreases tau phosphorylation. Cu(II)GTSM also decreases the abundance of Amyloid-β trimers. Cu(II)GTSM is a potential anticancer and antimicrobial agent.

For research use only. We do not sell to patients.

Cu(II)GTSM Chemical Structure

Cu(II)GTSM Chemical Structure

CAS No. : 68341-14-0

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Description

Cu(II)GTSM, a cell-permeable Cu-complex, significantly inhibits GSK3β. Cu(II)GTSM inhibits Amyloid-β oligomers (AβOs) and decreases tau phosphorylation. Cu(II)GTSM also decreases the abundance of Amyloid-β trimers. Cu(II)GTSM is a potential anticancer and antimicrobial agent[1][2].

IC50 & Target[2]

GSK3β

 

Amyloid-β oligomers

 

In Vitro

Cu(II)GTSM induces GSK3β phosphorylation at serine-9 (ser9) via its upstream kinase, protein kinase B (Akt), and aslo increases the phosphorylation of the associated extracellular signal-related kinase 1/2 (ERK1/2) in SH-SY5Y cells.
Tau phosphorylation at ser404 was decreased in CuII(gtsm)-treated cells by 64%[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: SH-SY5Y cells
Concentration: 25 μM
Incubation Time: 2 hours
Result: Inhibits GSK3β and decreases Tau phosphorylation.
In Vivo

Cu(II)GTSM decreases brain Aβ trimer levels in AD mice, and can reverse cognitive deficits in APP/PS1 transgenic AD mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: AD mice (K670N, M671L; 5-6 months old)[2]
Dosage: 10 mg/kg
Administration: Daily; p.o.
Result: Restores cognitive performance of the AD mice to levels expected for healthy, cognitively normal mice.
Molecular Weight

293.86

Formula

C₆H₁₀CuN₆S₂

CAS No.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Cu(II)GTSM
Cat. No.:
HY-139324
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