Search Result

Pathways Recommended:	MAPK/ERK Pathway

Results for "

p38/ERK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ERK (81) p38 MAPK (110) ADAMTS (1) Adrenergic Receptor (7) Akt (25) AMPK (3) Androgen Receptor (2) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) AP-1 (8) Apoptosis (40) Arginase (1) Aryl Hydrocarbon Receptor (6) Autophagy (14) Bacterial (9) Bcl-2 Family (2) Btk (1) Calcium Channel (4) Caspase (12) Cathepsin (1) CCR (1) CDK (1) Chemerin Receptor (1) Cholinesterase (ChE) (2) COX (15) CXCR (2) Cytochrome P450 (8) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (1) Dopamine Receptor (2) Drug Derivative (1) Drug Metabolite (6) EGFR (5) Endogenous Metabolite (2) Estrogen Receptor/ERR (1) Eukaryotic Initiation Factor (eIF) (2) FAK (1) Fc Receptor (FcR) (1) Ferroptosis (2) Formyl Peptide Receptor (FPR) (1) Fungal (3) FXR (1) G protein-coupled Bile Acid Receptor 1 (1) Glutathione Peroxidase (2) Glutathione Reductase (GR) (1) HBV (1) HDAC (1) Heme Oxygenase (HO) (1) Herbicide (2) HIF/HIF Prolyl-Hydroxylase (4) HSV (2) IAP (1) IFNAR (1) IKK (4) Interleukin Related (28) Isotope-Labeled Compounds (3) JAK (2) JNK (53) Keap1-Nrf2 (6) Lipoxygenase (2) LPL Receptor (1) MAP3K (2) MAPKAPK2 (MK2) (1) MDM-2/p53 (1) MEK (7) Microtubule/Tubulin (1) Mitochondrial Metabolism (8) MMP (12) MNK (2) mTOR (4) NF-κB (49) NO Synthase (12) NOD-like Receptor (NLR) (4) P-selectin (1) PAI-1 (2) PARP (3) PERK (12) PGE synthase (3) Phosphatase (4) Phosphodiesterase (PDE) (3) Phospholipase (1) PI3K (14) PKC (2) Potassium Channel (4) PPAR (4) Prostaglandin Receptor (5) Protease Activated Receptor (PAR) (3) PTEN (1) RANKL/RANK (1) Ras (1) Reactive Oxygen Species (ROS) (25) Reference Standards (27) SARS-CoV (3) Sirtuin (3) SOD (2) Src (3) STAT (8) Syk (1) TGF-beta/Smad (4) TNF Receptor (27) Toll-like Receptor (TLR) (4) Transmembrane Glycoprotein (1) TRP Channel (1) TSH Receptor (2) Tyrosinase (5) UGT (1) VEGFR (1) Wnt (6) β-catenin (6)
By Research Areas:	Cancer (64) Cardiovascular Disease (30) Endocrinology (2) Infection (23) Inflammation/Immunology (82) Metabolic Disease (24) Neurological Disease (35)

By Targets:

ERK (81)

p38 MAPK (110)

ADAMTS (1)

Adrenergic Receptor (7)

Akt (25)

AMPK (3)

Androgen Receptor (2)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (1)

AP-1 (8)

Apoptosis (40)

Arginase (1)

Aryl Hydrocarbon Receptor (6)

Autophagy (14)

Bacterial (9)

Bcl-2 Family (2)

Btk (1)

Calcium Channel (4)

Caspase (12)

Cathepsin (1)

CCR (1)

CDK (1)

Chemerin Receptor (1)

Cholinesterase (ChE) (2)

COX (15)

CXCR (2)

Cytochrome P450 (8)

Dipeptidyl Peptidase (1)

DNA/RNA Synthesis (1)

Dopamine Receptor (2)

Drug Derivative (1)

Drug Metabolite (6)

EGFR (5)

Endogenous Metabolite (2)

Estrogen Receptor/ERR (1)

Eukaryotic Initiation Factor (eIF) (2)

FAK (1)

Fc Receptor (FcR) (1)

Ferroptosis (2)

Formyl Peptide Receptor (FPR) (1)

Fungal (3)

FXR (1)

G protein-coupled Bile Acid Receptor 1 (1)

Glutathione Peroxidase (2)

Glutathione Reductase (GR) (1)

HBV (1)

HDAC (1)

Heme Oxygenase (HO) (1)

Herbicide (2)

HIF/HIF Prolyl-Hydroxylase (4)

HSV (2)

IAP (1)

IFNAR (1)

IKK (4)

Interleukin Related (28)

Isotope-Labeled Compounds (3)

JAK (2)

JNK (53)

Keap1-Nrf2 (6)

Lipoxygenase (2)

LPL Receptor (1)

MAP3K (2)

MAPKAPK2 (MK2) (1)

MDM-2/p53 (1)

MEK (7)

Microtubule/Tubulin (1)

Mitochondrial Metabolism (8)

MMP (12)

MNK (2)

mTOR (4)

NF-κB (49)

NO Synthase (12)

NOD-like Receptor (NLR) (4)

P-selectin (1)

PAI-1 (2)

PARP (3)

PERK (12)

PGE synthase (3)

Phosphatase (4)

Phosphodiesterase (PDE) (3)

Phospholipase (1)

PI3K (14)

PKC (2)

Potassium Channel (4)

PPAR (4)

Prostaglandin Receptor (5)

Protease Activated Receptor (PAR) (3)

PTEN (1)

RANKL/RANK (1)

Ras (1)

Reactive Oxygen Species (ROS) (25)

Reference Standards (27)

SARS-CoV (3)

Sirtuin (3)

SOD (2)

Src (3)

STAT (8)

Syk (1)

TGF-beta/Smad (4)

TNF Receptor (27)

Toll-like Receptor (TLR) (4)

Transmembrane Glycoprotein (1)

TRP Channel (1)

TSH Receptor (2)

Tyrosinase (5)

UGT (1)

VEGFR (1)

Wnt (6)

β-catenin (6)

By Research Areas:

Cancer (64)

Cardiovascular Disease (30)

Endocrinology (2)

Infection (23)

Inflammation/Immunology (82)

Metabolic Disease (24)

Neurological Disease (35)

151

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Desipramine hydrochloride 10+ Cited Publications	Adrenergic Receptor ERK JNK p38 MAPK NF-κB AP-1 Apoptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism TNF Receptor	Neurological Disease Inflammation/Immunology Cancer
Desipramine hydrochloride is a first-generation tricyclic antidepressant. Desipramine hydrochloride selectively binds to norepinephrine transporter and blocks neuronal norepinephrine reuptake. Desipramine hydrochloride activates MAPK signaling via *ERK1/2, JNK, and p38, represses NF-κB* and AP-1 activity, and induces apoptosis via ROS elevation, mitochondrial membrane potential reduction, and intracellular calcium increase. Desipramine hydrochloride also shows anyi-inflammatory activity, inhibiting TNF-α production. Desipramine hydrochloride can be used for the research of hepatocellular cancer, inflammation, and neurological diseases .

Amiodarone 10+ Cited Publications	Potassium Channel Autophagy	Cardiovascular Disease Infection Neurological Disease Cancer
Amiodarone, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outward ionic current (IhERG) tails with an IC₅₀ of ∼45 nM . Amiodarone induces cell proliferation and myofibroblast differentiation via *ERK1/2* and p38 MAPK signaling in fibroblasts . Amiodarone can be used in the research of both supraventricular and ventricular arrhythmias .

Ralimetinib dimesylate 10+ Cited Publications LY2228820 dimesylate	p38 MAPK Autophagy Apoptosis	Inflammation/Immunology Cancer
Ralimetinib dimesylate (LY2228820 dimesylate) is a selective, ATP-competitive inhibitor of p38 MAPK α/β with IC₅₀s of 5.3 and 3.2 nM, respectively. Ralimetinib (LY2228820) selectively inhibits phosphorylation of MK2 (Thr334), with no effect on phosphorylation of p38a MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc.

Amiodarone hydrochloride 10+ Cited Publications	Potassium Channel Autophagy	Cardiovascular Disease Infection Neurological Disease Cancer
Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outward ionic current (IhERG) tails with an IC₅₀ of ∼45 nM . Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via *ERK1/2* and p38 MAPK signaling in fibroblasts . Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias .

Asperosaponin VI 3 Publications Verification Akebia saponin D	Caspase Apoptosis PERK p38 MAPK Akt HIF/HIF Prolyl-Hydroxylase PPAR	Cardiovascular Disease Neurological Disease
Asperosaponin VI is a saponin component from Dipsacus asper. Asperosaponin VI induces osteoblast differentiation through the *BMP-2/p38* and *ERK1/2* signaling pathways. Asperosaponin VI protects against hypoxia-induced cardiomyocyte apoptosis by activating the PI3K/Akt and CREB pathways. Additionally, Asperosaponin VI also has antidepressant and wound-healing-promoting activities .

Ononin Maximum Cited Publications 11 Publications Verification Ononoside; Formononetin 7-O-β-D-glucopyranoside	ERK JNK p38 MAPK PI3K Akt mTOR Apoptosis	Neurological Disease Metabolic Disease Cancer
Ononin is an orally active isoflavone. Ononin inhibits the *ERK/JNK/p38* and PI3K/Akt/mTOR pathways. Ononin regulates Apoptosis. Ononin has anti-tumor effects on laryngeal cancer and lung cancer. Ononin has neuroprotective effects. Ononin alleviates endoplasmic reticulum stress and diabetic nephropathy .

Mulberroside A 4 Publications Verification	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

Butein 5+ Cited Publications 2’,3,4,4’-tetrahydroxy Chalcone	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)	Cancer
Butein is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR and p60 ^c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

Flavanone 1 Publications Verification	Cytochrome P450 ERK p38 MAPK NF-κB MMP PAI-1	Cancer
Flavanone is a naturally occurring flavone. Flavanone has inhibitory activity for human estrogen synthetase (aromatase). Flavanone is the inhibitor for *ERK/p38/NF-κB* signaling pathway. Flavanone exhibits oral activity and antitumor efficacy .

Candidalysin	EGFR MMP Calcium Channel NOD-like Receptor (NLR) ERK p38 MAPK	Infection Inflammation/Immunology
Candidalysin is a cytolytic peptide toxin secreted by the fungus Candida albicans. Candidalysin drives epithelial immune responses by activating the EGFR-MAPK signaling pathway, inducing MMP expression and calcium influx, and regulating the c-Fos transcription factor and MKP1 via p38 MAPK and *ERK1/2* respectively. Candidalysin is essential for mucosal and systemic infections, activating NLRP3 to promote inflammatory responses, neutrophil recruitment, and Th17 immunity. Candidalysin activates LDH causing membrane damage and exhibiting cytotoxicity

2"-O-Galloylhyperin 2 Publications Verification	Sirtuin Keap1-Nrf2 NF-κB ERK p38 MAPK JNK TSH Receptor Reactive Oxygen Species (ROS) SOD	Neurological Disease Inflammation/Immunology
2''-O-Galloylhyperin is an active natural compound with anti‑inflammatory, antioxidant, anti‑adipogenic, antifibrotic, and cytostatic activities. 2''-O-Galloylhyperin upregulates SIRT1/Nrf2 signaling, inhibits NF-κB and *MAPK (ERK1/2, p38, JNK)* phosphorylation, suppresses TSHR activation, reduces ROS accumulation, and enhances SOD and GSH-Px activities. 2''-O-Galloylhyperin protects against LPS-induced tissue injury, enhances survival, and inhibits adipogenesis and fibrosis. 2"-O-Galloylhyperin can be used for the research of sepsis, acute lung injury, and thyroid eye disease .

CGP 57380 3 Publications Verification	MNK Apoptosis	Cancer
CGP 57380 is a cell-permeable pyrazolo-pyrimidine compound that acts as a selective inhibitor of Mnk1 with IC₅₀ of 2.2 μM, but has no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases.

Gypenoside L 4 Publications Verification	p38 MAPK ERK NF-κB	Inflammation/Immunology Cancer
Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L increases the SA-β-galactosidase activity, promotes the production of senescence-associated secretory cytokines. Gypenoside L also can activate *p38* and ERK MAPK pathways and NF-κB pathway to induce senescence. Gypenoside L exhibits anti-tumor and anti-inflammatory activities .

Latanoprost acid 1 Publications Verification	Prostaglandin Receptor ERK Akt JNK p38 MAPK	Inflammation/Immunology
Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor . Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting *ERK, AKT, JNK, and p38* cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes .

Cyanidin 3,5-diglucoside chloride	Interleukin Related NO Synthase STAT IKK PERK p38 MAPK Akt	Neurological Disease Inflammation/Immunology
Cyanidin 3,5-diglucoside chloride is an anthocyanin. Cyanidin 3,5-diglucoside chloride inhibits inflammatory cytokines (IL-1α, IL-1β, and IL-6) expression and NO production. Cyanidin 3,5-diglucoside chloride inhibits the phosphorylation of STAT3, IκB, *ERK, p38, and AKT. Cyanidin 3,5-diglucoside chloride inhibits high pressure-induced decrease in GLAST*. Cyanidin 3,5-diglucoside chloride exerts anti-inflammatory and skin barrier modulating effects. Cyanidin 3,5-diglucoside chloride can be used in retinal research .

Chemerin15	Chemerin Receptor Syk ERK Src p38 MAPK P-selectin	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Chemerin15 is an anti-inflammatory peptide derived from Chemerin. Chemerin15 binds to ChemR23. Chemerin15 inhibits TNFα-induced activation of Syk, *ERK* and Src kinases. Chemerin15 increases the expression of *p-p38* mRNA and protein. Chemerin15 mediates phagocytosis, resolution of inflammation, CD62L shedding and downregulation of PSGL-1 expression in macrophages and microglia. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury via ChemR23. Chemerin15 enhances microglial phagocytosis, thereby alleviating cerebral ischemia-reperfusion injury .

Sesamolin 2 Publications Verification	p38 MAPK JNK Caspase Reactive Oxygen Species (ROS) NF-κB	Neurological Disease Metabolic Disease Inflammation/Immunology
Sesamolin, isolated from Sesamum indicum, has antioxidative activity, Sesamolin inhibits lipid peroxidation and shows neuroprotection effect. Sesamolinl potently inhibits MAPK cascades by preventing phosphorylation of JNK, p38 MAPKs, and caspase-3 but not ERK-MAPK expression. Sesamolin is orally active .

12(S)-HETE	ERK DNA/RNA Synthesis p38 MAPK	Cancer
12(S)-HETE is the 12-lipoxygenase metabolite of arachidonic acid and has a mitogenic effect on cancer cell proliferation. 12(S)-HETE induces tyrosine phosphorylation of cellular proteins, promotes ERK and P38 MAPK phosphorylation, increases DNA synthesis, and stimulates the proliferation of pancreatic cancer cells .

Broussonin E 2 Publications Verification	ERK p38 MAPK JAK STAT TNF Receptor Interleukin Related COX Arginase	Inflammation/Immunology
Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the *ERK* and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis .

(±)-Stylopine 1 Publications Verification Tetrahydrocoptisine	Interleukin Related NO Synthase p38 MAPK PERK NF-κB	Neurological Disease Inflammation/Immunology
(±)-Stylopine (Tetrahydrocoptisine) is an alkaloid compound. (±)-Stylopine can be isolated from the tubers of the plant Corydalis. (±)-Stylopine inhibits TNF-α, IL-6, and NO production, and attenuates phosphorylation of p38 MAPK, *ERK1/2. (±)-Stylopine inhibits NF-κB* expression. (±)-Stylopine exhibits anti-inflammatory activity. (±)-Stylopine has protective effects against foot edema, gastric ulcers, anxiety, depression, and acute lung injury .

Verrucarin A 1 Publications Verification Muconomycin A	Apoptosis Reactive Oxygen Species (ROS)	Cancer
Verrucarin A (Muconomycin A), a Type D macrocyclic mycotoxin derived from the pathogen fungus Myrothecium verrucaria, is an inhibitor of protein synthesis. Verrucarin A inhibits growth of leukemia cell lines and activates caspases and apoptosis and inflammatory signaling in macrophages. Verrucarin A effectively increased the phosphorylation of p38 MAPK and diminished the phosphorylation of ERK/Akt. Verrucarin A caused cell cycle deregulation through the induction of p21 and p53 .

Saponarin 1 Publications Verification	PERK NF-κB p38 MAPK AMPK Interleukin Related COX	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Saponarin is an orally active flavonoid compound. Saponarin can be isolated from Gypsophila trichotoma. Saponarin inhibits *ERK/p38, NF-κB* and MAPK phosphorylation and activates AMPK. Saponarin reduces IL-1β and COX-2. Saponarin has antioxidant, anti-inflammatory, hepatoprotective, hypoglycemic and hypotensive effects. Saponarin improves sleep disorders .

OR-1855 1 Publications Verification	Drug Metabolite Reactive Oxygen Species (ROS) ERK p38 MAPK	Cardiovascular Disease Inflammation/Immunology
OR-1855, an active metabolite of Levosimendan (HY-14286), has effect on myometrial contractility. OR-1855 exerts anti-inflammatory effects by inhibiting IL-1β-induced ROS formation and NAD(P)H oxidase-dependent superoxide radical generation in HUVECs. OR-1855 inhibits IL-1β-induced phosphorylation p38 MAPK, *ERK1/2, c-Jun* and JNK in HUVECs. OR-1855 can be used for the study of inflammation .

Isosilybin A 2 Publications Verification	Apoptosis PPAR NF-κB p38 MAPK ERK Androgen Receptor	Inflammation/Immunology Cancer
Isosilybin A is a PPARγ agonist that can be isolated from silymarin. Isosilybin A activates extrinsic and intrinsic pathways of apoptosis through targeting of the Akt-NF-kB-AR axis. Isosilybin A can relieve the inflammatory response in the rosacea model via inhibiting *Erk* and *p38* signaling pathways and M1 macrophage polarization, with its targets related to RELA and VEGFA. Isosilybin A has anti-prostate cancer (PCA) activity ^[1][2][3].

Meptyldinocap 2,4-DNOPC	Fungal ERK JNK p38 MAPK Apoptosis Mitochondrial Metabolism	Infection Endocrinology
Meptyldinocap (2,4-DNOPC) is a fungicide and cytotoxic agent that acts against powdery mildew. Meptyldinocap upregulates the phosphorylation levels of *ERK1/2, JNK* and *p38. Meptyldinocap induces apoptosis* and endoplasmic reticulum stress, disrupts calcium homeostasis, inhibits cell proliferation and migration, downregulates the expression of proliferation- and pregnancy-related genes, and triggers mitochondrial dysfunction. Meptyldinocap can be used in studies related to powdery mildew and implantation failure .

4-Hydroxylonchocarpin 2 Publications Verification	p38 MAPK Apoptosis Reactive Oxygen Species (ROS)	Infection Metabolic Disease Inflammation/Immunology Cancer
4-Hydroxylonchocarpin is a chalcone compound. 4-Hydroxylonchocarpin enhances the phosphorylation of p38 MAPK, JNK and ERK. 4-Hydroxylonchocarpin induces reactive oxygen species (ROS) and apoptosis in liver cancer cells. 4-Hydroxylonchocarpin has various pharmacological activities, including antibacterial, anticancer, anti-retroviral, anti-tuberculosis, anti-malarial and anti-inflammatory activities .

ATUX-1215	Phosphatase Apoptosis	Inflammation/Immunology Cancer
ATUX-1215 is an activator of protein phosphatase 2A (PP2A). ATUX-1215 reduced the phosphorylation of ERK, p38, JNK, and Akt and the secretion of IL-12p70, GM-CSF, and IL1α in Bleomycin hydrochloride (HY-17565A)-treated animals. ATUX-1215 can slow the progression of lung fibrosis .

Gallic aldehyde 1 Publications Verification	HSV MMP ERK p38 MAPK JNK	Infection
Gallic aldehyde (3,4,5-Trihydroxybenzaldehyde) is a phenolic aldehyde. Gallic aldehyde can be isolated from Geum japonicum. Gallic aldehyde inhibits the gelatinolytic activity and expression of MMP-9. Gallic aldehyde also inhibits *ERK1/2, p38, and JNK. Gallic aldehyde has potent anti-HSV-1* and antioxidant activities. Gallic aldehyde also exhibits antibacterial activity against Oenococcus oeni VF .

Edpetiline 2 Publications Verification	NF-κB p38 MAPK TNF Receptor Reactive Oxygen Species (ROS) COX Interleukin Related	Inflammation/Immunology
Edpetiline is an anti-inflammatory agent. Edpetiline inhibits the phosphorylation of IκB, nuclear transcription/translocation of NF-κB p65, as well as the phosphorylation of p38 MAPK and ERK MAPK. Edpetiline reduces intracellular ROS levels, inhibits the expression of TNF-α, IL-6, iNOS, COX-2, and promotes the expression of IL-4. Edpetiline is applicable to the research of diseases associated with inflammation and oxidative stress .

5F-203 NSC-703786	Aryl Hydrocarbon Receptor	Others
5F-203 (NSC-703786) is a cytotoxic molecule that forms DNA adducts and cell cycle arrest. 5F-203 induces aryl hydrocarbon receptor (AhR) signaling and elevates expression of CYP1A1. 5F-203 also increases the levels of reactive oxygen species as well as activates JNK, ERK, and p38 .

SY-LB-35	TGF-beta/Smad PI3K Akt ERK JNK	Others
SY-LB-35 is a potent bone morphogenetic protein (BMP) receptor agonist. SY-LB-35 can stimulate significant increases in cell number and cell viability in the C2C12 myoblast cell line, and causes shifts towards the S and G2/M phases of the cell cycle. SY-LB-35 stimulates canonical Smad and non-canonical PI3K/Akt, *ERK, p38* and JNK intracellular signaling pathways .

Artocarpin	Reactive Oxygen Species (ROS)	Cancer
Artocarpin is an orally active apoptosis inducer. Artocarpin targets NF-κB, *Erk1/2, p38* MAPK, AktS473, p53, Akt 1 kinase and Akt 2 kinase. Artocarpin induces reactive oxygen species (ROS) production, mediates p53-dependent and p53-independent apoptotic signaling pathways, induces G1-phase cell cycle arrest, and triggers autophagic cell death. Artocarpin exerts cytotoxic and bactericidal effects on cancer cells, reduces bacterial load, and exhibits anti-inflammatory, analgesic and anti-angiogenic activities .

Viridicatol	ERK JNK MMP p38 MAPK STAT Fungal Bacterial NO Synthase PGE synthase NF-κB Wnt β-catenin	Infection Metabolic Disease Inflammation/Immunology
Viridicatol is a quinolone alkaloid with anti-inflammatory, antibacterial, antifungal, osteogenic and chondrogenic activities. Viridicatol reduces the phosphorylation levels of *ERK, JNK, p38* and STAT6; inhibits MMP-2, MMP-9, NF-κB signaling pathway and PTP1B; downregulates genes related to mast cell activation; and binds to SHN3 to activate the Wnt/SHN3 signaling pathway. Viridicatol inhibits the expression of pro-inflammatory mediators and cytokines, and promotes osteogenic/chondrogenic differentiation. Viridicatol can be used in studies related to fibrosarcoma, allergy, bacterial infection, fungal infection and osteoporosis .

Asatone 3 Publications Verification	NF-κB	Inflammation/Immunology
Asatone is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways .

Paeonolide	ERK TGF-beta/Smad Wnt β-catenin JNK p38 MAPK	Metabolic Disease Inflammation/Immunology
Paeonolide, found in Paeonia suffruticosa, is an *ERK1/2* activator. Paeonolide promotes early and late osteoblast differentiation, stimulates pre-osteoblast transmigration, and activates the BMP-Smad1/5/8, Wnt-β-catenin, JNK and p38 pathways. Paeonolide can be used for the research of osteoporosis, periodontitis .

Cathepsin G	Cathepsin ERK p38 MAPK PKC Protease Activated Receptor (PAR) MMP	Inflammation/Immunology
Cathepsin G is a pH-dependent serine protease. Cathepsin G hydrolyzes diverse synthetic and protein substrates and remodels extracellular matrix. Cathepsin G exerts immunomodulatory effects via recruiting phagocytes, enhancing T cell motility, activating *ERK1/2* and p38 MAPK signaling, and mediating PKCζ membrane translocation. Cathepsin G regulates inflammatory responses by cleaving inflammatory mediators. Cathepsin G participates in vascular regulation by converting angiotensin I to angiotensin II. Cathepsin G induces PAR4-dependent platelet activation, facilitates platelet-neutrophil aggregation, and mediates VITT-related NETosis, thrombus formation. Cathepsin G can be used for the research of immune thrombotic thrombocytopenia, cardiovascular disease, and select autoimmune and inflammatory diseases .

Chicanine 1 Publications Verification	p38 MAPK ERK IKK	Inflammation/Immunology
Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of p38 MAPK, ERK 1/2 and IκB-α, with anti-inflammatory activity .

Desipramine	Adrenergic Receptor ERK JNK p38 MAPK NF-κB AP-1 Apoptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism TNF Receptor	Neurological Disease Inflammation/Immunology Cancer
Desipramine is a first-generation tricyclic antidepressant. Desipramine selectively binds to norepinephrine transporter and blocks neuronal norepinephrine reuptake. Desipramine activates MAPK signaling via *ERK1/2, JNK, and p38, represses NF-κB* and AP-1 activity, and induces apoptosis via ROS elevation, mitochondrial membrane potential reduction, and intracellular calcium increase. Desipramine also shows anyi-inflammatory activity, inhibiting TNF-α production. Desipramine can be used for the research of hepatocellular cancer, inflammation, and neurological diseases .

Alisol F 1 Publications Verification	HBV ERK JNK p38 MAPK STAT NF-κB TNF Receptor Interleukin Related NO Synthase COX	Metabolic Disease Cancer
Alisol F is a protostane-type triterpenoid with anti-inflammatory and anti-hepatitis B virus activities. Alisol F inhibits LPS (HY-D1056)-induced phosphorylation of *ERK, JNK, p38, STAT3* and NF-κB (p65), suppresses the production of NO, IL-6, TNF-α and IL-1β, and also downregulates the levels of iNOS and COX-2. Alisol F reduces the serum alanine aminotransferase and aspartate aminotransferase levels in mice with acute liver injury and ameliorates their liver pathological damage .

Cavidine (+)-Cavidine	p38 MAPK ERK Interleukin Related	Neurological Disease Inflammation/Immunology
Cavidine ((+)-Cavidine) is an analgesic and anti-inflammatory agent. Cavidine can be isolated from Corydalis ternata f. yanhusuo (Y.H.Chou & Chun C.Hsu) Y.C.Zhu. Cavidine reduces the expression of inflammatory factors IL-1β, IL-6 and TNF-α, and inhibits calcium ion influx. Cavidine inhibits the phosphorylation of *p38* and *ERK1/2*. Cavidine increases mechanical and thermal pain thresholds in chronic pain models. Cavidine can be used for the research of chronic pain .

JD123	p38 MAPK JNK	Cancer
JD123 inhibits JNK1 activity and the expression of cJun (1-135). JD123 is a ATP-competitive p38-γ MAPK inhibitor, but not effect to ERK1, ERK2, or p38-α, p38-β or p38-δ. .

Emodic acid NSC624610	p38 MAPK NF-κB ERK JNK VEGFR MMP	Cancer
Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of *p38, ERK* and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells .

Umckalin	p38 MAPK JNK ERK TNF Receptor Interleukin Related PI3K Akt	Inflammation/Immunology
Umckalin is Coumarin (HY-N0709) derivative that exhibits anti-inflammatory properties. Umckalin reduces phosphorylation of p38 MAPK, JNK, and *ERK, lowers TNF-α, IL-6, IL-1β*, NO, and PGE₂ production. Umckalin can be used for the research of chronic inflammatory diseases .

ROC-0929	Phospholipase	Inflammation/Immunology
ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A₂ (sPLA₂s) with an IC₅₀ of 80 nM, specially targeting hGX. ROC-0929 inhibits the phosphorylation of *ERK1/2* and *p-38. Secreted phospholipases A2 (sPLA2s)* are a family of disulfide-rich, Ca ²⁺-dependent enzymes that hydrolyze the sn-2 position of glycero-phospholipids to release a fatty acid and a lysophospholipid. ROC-0929 has the potential for researching inflammation related diseases .

Amiodarone hydrochloride (Standard)	Reference Standards Potassium Channel Autophagy	Cardiovascular Disease Cancer
Amiodarone (hydrochloride) (Standard) is the analytical standard of Amiodarone (hydrochloride). This product is intended for research and analytical applications. Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC₅₀ of ∼45 nM . Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via *ERK1/2* and p38 MAPK signaling in fibroblasts . Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias .

Asperosaponin VI (Standard) Akebia saponin D (Standard)	Reference Standards Caspase Apoptosis PERK Akt p38 MAPK HIF/HIF Prolyl-Hydroxylase PPAR	Cardiovascular Disease Neurological Disease
Asperosaponin VI (Standard) is the analytical standard of Asperosaponin VI. This product is intended for research and analytical applications. Asperosaponin VI is a saponin component from Dipsacus asper. Asperosaponin VI induces osteoblast differentiation through the *BMP-2/p38* and *ERK1/2* signaling pathways. Asperosaponin VI protects against hypoxia-induced cardiomyocyte apoptosis by activating the PI3K/Akt and CREB pathways. Additionally, Asperosaponin VI also has antidepressant and wound-healing-promoting activities .

Cat. No.	상품명

HY-L010

MAPK Compound Library

1,063 compounds

MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. In mammalian cells, four MAPK families have been clearly characterized: ERK1/2, C-Jun N-terminal kinse/stress-activated protein kinase (JNK/SAPK) , p38 kinase and ERK5. They respond to different signals. Each MAPK-related cascade consists of three enzymes that are activated in series: a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK) and a MAP kinase (MAPK). MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers.

MCE designs a unique collection of 1,063 MAPK signaling pathway inhibitors that act as a useful tool for MAPK-related drug screening and disease research.

Cat. No.	상품명	Type

HY-B2162D

Chondroitin sulfate (from chicken)

Chondroitin polysulfate (from chicken)

Biochemical Assay Reagents

Chondroitin sulfate (from chicken) (Chondroitin polysulfate (from chicken)) is an orally active, sulfated linear polysaccharide extracted from chickens, which belongs to glycosaminoglycans. Chondroitin sulfate (from chicken) reduces the phosphorylation levels of ERK1/2 and p38MAPK, inhibits the expression of inflammatory cytokines and MMP, and downregulates the levels of IL-1β, IL-6, TNF-α and PGE₂. Chondroitin sulfate (from chicken) improves motor function, protects cartilage tissue, reverses chondrocyte aggregation, and regulates the structure of intestinal flora. Chondroitin sulfate (from chicken) can be used in research related to osteoarthritis .

HY-W745090

Isomaltulose monohydrate

Biochemical Assay Reagents

Isomaltulose monohydrate is a fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Isomaltulose monohydrate can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Isomaltulose monohydrate inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM) , cathepsin G release (IC< sub>50: 2.76 μM) and chemotaxis. Isomaltulose monohydrate can improve excessive activation of neutrophils and reduce inflammation or tissue damage. A series of derivatives of Isomaltulose monohydrate are found to have inhibitory effects on FSGS-related TRPC6 functional mutants .

Cat. No.	상품명	Target	Research Area

HY-P10408

Candidalysin	EGFR MMP Calcium Channel NOD-like Receptor (NLR) ERK p38 MAPK	Infection Inflammation/Immunology
Candidalysin is a cytolytic peptide toxin secreted by the fungus Candida albicans. Candidalysin drives epithelial immune responses by activating the EGFR-MAPK signaling pathway, inducing MMP expression and calcium influx, and regulating the c-Fos transcription factor and MKP1 via p38 MAPK and *ERK1/2* respectively. Candidalysin is essential for mucosal and systemic infections, activating NLRP3 to promote inflammatory responses, neutrophil recruitment, and Th17 immunity. Candidalysin activates LDH causing membrane damage and exhibiting cytotoxicity

HY-P6442

Chemerin15	Chemerin Receptor Syk ERK Src p38 MAPK P-selectin	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Chemerin15 is an anti-inflammatory peptide derived from Chemerin. Chemerin15 binds to ChemR23. Chemerin15 inhibits TNFα-induced activation of Syk, *ERK* and Src kinases. Chemerin15 increases the expression of *p-p38* mRNA and protein. Chemerin15 mediates phagocytosis, resolution of inflammation, CD62L shedding and downregulation of PSGL-1 expression in macrophages and microglia. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury via ChemR23. Chemerin15 enhances microglial phagocytosis, thereby alleviating cerebral ischemia-reperfusion injury .

HY-P3012

Cathepsin G	Cathepsin ERK p38 MAPK PKC Protease Activated Receptor (PAR) MMP	Inflammation/Immunology
Cathepsin G is a pH-dependent serine protease. Cathepsin G hydrolyzes diverse synthetic and protein substrates and remodels extracellular matrix. Cathepsin G exerts immunomodulatory effects via recruiting phagocytes, enhancing T cell motility, activating *ERK1/2* and p38 MAPK signaling, and mediating PKCζ membrane translocation. Cathepsin G regulates inflammatory responses by cleaving inflammatory mediators. Cathepsin G participates in vascular regulation by converting angiotensin I to angiotensin II. Cathepsin G induces PAR4-dependent platelet activation, facilitates platelet-neutrophil aggregation, and mediates VITT-related NETosis, thrombus formation. Cathepsin G can be used for the research of immune thrombotic thrombocytopenia, cardiovascular disease, and select autoimmune and inflammatory diseases .

HY-P5522A

TriDAP dihydrochloride 1 Publications Verification L-Ala-γ-D-Glu-meso-diaminopimelic acid dihydrochloride	NOD-like Receptor (NLR) NF-κB MAP3K MEK ERK p38 MAPK Interleukin Related SARS-CoV	Infection Inflammation/Immunology
TriDAP dihydrochloride (L-Ala-γ-D-Glu-meso-diaminopimelic acid dihydrochloride) is a NOD1 agonist with a K_d value of 34.5 μM. TriDAP dihydrochloride enhances the binding of NOD1-RICK, promotes RICK phosphorylation, and activates the NF-κB, TAK1, *MEK/ERK, p38* and interferon response pathways. TriDAP dihydrochloride downregulates Runx2 via increasing ubiquitination and reduces trabecular bone parameters. TriDAP dihydrochloride decreases IκBα levels and increases p65 levels. TriDAP dihydrochloride induces the secretion of proinflammatory mediators IL-8 and prostaglandins, triggers tissue inflammation and innate immune activation, and inhibits SARS-CoV-2 replication in lung epithelial cells. TriDAP dihydrochloride increases the RANKL/OPG ratio in mice, reduces bone mass and enhances osteoclast activity, and inhibits new bone formation by decreasing the mineralization deposition rate in mice. TriDAP dihydrochloride can be used in research related to pulpitis, chronic ulcerative colitis, Crohn's disease and SARS-CoV-2 infection .

HY-P5522

TriDAP L-Ala-γ-D-Glu-meso-diaminopimelic acid	NOD-like Receptor (NLR) NF-κB MAP3K MEK ERK p38 MAPK Interleukin Related SARS-CoV	Infection Inflammation/Immunology
TriDAP (L-Ala-γ-D-Glu-meso-diaminopimelic acid) is a NOD1 agonist with a K_d value of 34.5 μM. TriDAP enhances the binding of NOD1-RICK, promotes RICK phosphorylation, and activates the NF-κB, TAK1, *MEK/ERK, p38* and interferon response pathways. TriDAP downregulates Runx2 via increasing ubiquitination and reduces trabecular bone parameters. TriDAP decreases IκBα levels and increases p65 levels. TriDAP induces the secretion of proinflammatory mediators IL-8 and prostaglandins, triggers tissue inflammation and innate immune activation, and inhibits SARS-CoV-2 replication in lung epithelial cells. TriDAP increases the RANKL/OPG ratio in mice, reduces bone mass and enhances osteoclast activity, and inhibits new bone formation by decreasing the mineralization deposition rate in mice. TriDAP can be used in research related to pulpitis, chronic ulcerative colitis, Crohn's disease and SARS-CoV-2 infection .

HY-P11250

HVF18-a3-d	Bacterial NO Synthase Interleukin Related Reactive Oxygen Species (ROS) Toll-like Receptor (TLR) ERK JNK p38 MAPK	Infection Inflammation/Immunology
HVF18-a3-d is an antimicrobial peptide. HVF18-a3-d reduces NO production. HVF18-a3-d inhibits the production of TNF-α and IL-6, reduces ROS production, and suppresses the TLR4 signaling pathway, as well as LPS-induced phosphorylation of *ERK, JNK, and p38* MAPK. HVF18-a3-d exhibits antimicrobial activity against a variety of bacteria by disrupting their outer and inner membranes. HVF18-a3-d protects mice from fatal septic shock induced by Acinetobacter baumannii resistant to Carbapenem. HVF18-a3-d shows anti-inflammatory and antioxidant effects .

HY-P11242

Cm-CATH2	Bacterial NF-κB p38 MAPK JNK ERK TNF Receptor Interleukin Related	Infection
Cm-CATH2 is an antimicrobial peptide discovered from Chelonia mydas. Cm-CATH2 has a potent, broad-spectrum and rapid bactericidal ability by rapidly destroying the integrity of bacterial cell membranes. It shows strong activity against Gram-positive bacteria (such as VREF, Staphylococcus aureus), Gram-negative bacteria (such as Escherichia coli, Klebsiella pneumoniae), and fungi (such as Candida albicans) with MICs ranges from 1.17 to 18.75 μg/mL. Cm-CATH2 is also effective against various aquatic pathogenic bacteria. Cm-CATH2 not only inhibits biofilm formation but can also remove the formed biofilms. Cm-CATH2 has immunomodulatory functions and chemotactic effects on immune cells, and can inhibit the production of pro-inflammatory cytokines by macrophages stimulated by LPS (HY-D1056). Cm-CATH2 prevents the activation of NF-κB by inhibiting the degradation of IκBα, and also inhibits the phosphorylation of MAPK signaling pathways (p38, JNK, *ERK*). Cm-CATH2 demonstrates strong anti-infective ability in mouse peritonitis models and pneumonia models .

HY-P11467

Gy-CATH	Bacterial p38 MAPK NF-κB PERK JNK	Cardiovascular Disease Infection
Gy-CATH is an anionic antimicrobial peptide. Gy-CATH activates MAPK and NF-κB signaling pathways (elevated levels of phospho-ERK, -p38, -JNK, -p65, and -IκBα). Gy-CATH upregulates the expression levels of three physiological anticoagulant pathways. Gy-CATH inhibits ADP-, Collagen-, and PMA-induced platelet aggregation. Gy-CATH has no direct antimicrobial activity, but shows significant preventive abilities against mice infected with Staphylococcus aureus, Escherichia coli, and Methicillin (HY-121544)-resistant Staphylococcus aureus. Gy-CATH exhibits potent immunomodulatory activity, enhancing macrophage-and neutrophil-mediated bactericidal functions. Gy-CATH significantly reduces the extent of pulmonary fibrin deposition and prevents thrombosis in mice .

Cat. No.	상품명	Target	Research Area	Image

HY-P991551

YS110	Dipeptidyl Peptidase p38 MAPK ERK	Infection Cancer
YS110 is a humanized anti-CD26 (DPP4) IgG1 monoclonal antibody. YS110 induces CD26 nuclear translocation through the caveolin pathway. YS110 inhibits the proliferation of tumor cell by delaying G2/M cell cycle transition. YS110 inhibits the infection of Middle East respiratory syndrome coronavirus (MERS CoV) by blocking the binding of MERS CoV S1 to CD26. YS110 can be used for researches on cancer or infection such as Malignant Mesothelioma and MERS .

HY-P991744

Anti-Mouse CXCR4 Antibody (Cx4Mab-1)	CXCR	Cancer
Anti-Mouse CXCR4 Antibody is a monoclonal antibody that specifically recognizes murine CXCR4 (C-X-C chemokine receptor 4), also known as fusin or CD184. CXCR4 is a seven-transmembrane G protein–coupled receptor whose principal endogenous ligand is CXCL12 (stromal cell–derived factor-1α, SDF-1α) and is widely expressed in hematopoietic cells, endothelial cells, neurons, as well as embryonic and adult stem cells. The CXCR4–CXCL12 signaling axis activates multiple downstream pathways, including ERK1/2, Ras, p38 MAPK, PLC/MAPK, and SAPK/JNK, thereby regulating cell survival, proliferation, migration, and stemness maintenance. Aberrant overexpression of CXCR4 is closely associated with poor prognosis and metastasis in various cancers, with CXCR4-positive tumor cells preferentially home to CXCL12-rich tissues such as the liver, bone marrow, lung, and lymph nodes. Accordingly, CXCR4 and its CXCL12-related antagonists emerge as attractive targets for experimental anticancer therapy. Anti-Mouse CXCR4 Antibody is generated using a cell-based immunization and screening strategy and exhibits high affinity for both endogenous and exogenous murine CXCR4. Anti-Mouse CXCR4 Antibody can be used for thestudy of chronic lymphocytic leukemia and multiple myeloma .

Species:	Human (5)
Tag:	His (1) Tag Free (1) GST (3) Flag (1)
Source:	Sf9 insect cells (3) E. coli (2)

Cat. No.	Compare	상품명	Species	Source	Image

HY-P703924

	p38 gamma/MAPK12 Protein, Human (sf9, GST) Mitogen-activated protein kinase 12; MAP kinase 12; MAPK 12; Extracellular signal-regulated kinase 6 (ERK-6); Mitogen-activated protein kinase p38 gamma (MAP kinase p38 gamma); Stress-activated protein kinase 3	Human	Sf9 insect cells
	The p38 gamma/MAPK12 protein is an important serine/threonine kinase in the MAP kinase pathway and can respond to extracellular stimuli such as pro-inflammatory cytokines or stress. p38 MAPK activates transcription factors such as ELK1 and ATF2, each of which phosphorylates approximately 200 to 300 substrates. p38 gamma/MAPK12 Protein, Human (Active, sf9, GST) is the recombinant human-derived p38 gamma/MAPK12 protein, expressed by Sf9 insect cells, with N-GST labeled tag.

HY-P76532

	p38 gamma/MAPK12 Protein, Human (sf9) Mitogen-activated protein kinase 12; Extracellular signal-regulated kinase 6; ERK-6; SAPK3	Human	Sf9 insect cells
	The p38 gamma/MAPK12 protein is an important serine/threonine kinase in the MAP kinase pathway and can respond to extracellular stimuli such as pro-inflammatory cytokines or stress. p38 MAPK activates transcription factors such as ELK1 and ATF2, each of which phosphorylates approximately 200 to 300 substrates. p38 gamma/MAPK12 Protein, Human (sf9) is the recombinant human-derived p38 gamma/MAPK12 protein, expressed by Sf9 insect cells, with tag free.

HY-P76533

	p38 gamma/MAPK12 Protein, Human (sf9, His-GST) Mitogen-activated protein kinase 12; Extracellular signal-regulated kinase 6; ERK-6; SAPK3	Human	Sf9 insect cells
	The p38 gamma/MAPK12 protein is an important serine/threonine kinase in the MAP kinase pathway and can respond to extracellular stimuli such as pro-inflammatory cytokines or stress. p38 MAPK activates transcription factors such as ELK1 and ATF2, each of which phosphorylates approximately 200 to 300 substrates. p38 gamma/MAPK12 Protein, Human (sf9, His-GST) is the recombinant human-derived p38 gamma/MAPK12 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P704008

	MAPK1/ERK2 Protein, Human (Inactive, GST) MAPK1; mitogen-activated protein kinase 1; PRKM1, PRKM2; ERK; ERK2; MAPK2; p41mapk; ERK-2; MAPK 2; p42-MAPK; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; protein tyrosine kinase ERK2; mitogen-activated protein kinase 2; extracellular signal-regulated kinase 2; p38; p40; p41; ERT1; PRKM1; PRKM2; P42MAPK	Human	E. coli
	ERK2 Protein, a key component of the MAPK/ERK cascade, regulates diverse cellular processes such as transcription, translation, mitosis, apoptosis, endosomal dynamics, and Golgi apparatus fragmentation. Through phosphorylation, it modulates substrates including transcription factors, cytoskeletal elements, apoptosis regulators, translation regulators, protein kinases, and phosphatases. MAPK1/ERK2 Protein, Human (Inactive, GST) is the recombinant human-derived MAPK1/ERK2 protein, expressed by E. coli, with N-GST labeled tag.

HY-P702735

	MAPK1/ERK2 Protein, Human (Active, Flag-His) MAPK1; mitogen-activated protein kinase 1; PRKM1, PRKM2; ERK; ERK2; MAPK2; p41mapk; ERK-2; MAPK 2; p42-MAPK; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; protein tyrosine kinase ERK2; mitogen-activated protein kinase 2; extracellular signal-regulated kinase 2; p38; p40; p41; ERT1; PRKM1; PRKM2; P42MAPK	Human	E. coli
	ERK2 Protein, a key component of the MAPK/ERK cascade, regulates diverse cellular processes such as transcription, translation, mitosis, apoptosis, endosomal dynamics, and Golgi apparatus fragmentation. Through phosphorylation, it modulates substrates including transcription factors, cytoskeletal elements, apoptosis regulators, translation regulators, protein kinases, and phosphatases. MAPK1 Protein, Human (Active, Flag, His) is the recombinant human-derived MAPK1, expressed by E. coli, with N-His, N-Flag labeled tag.

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Cat. No.	상품명	Chemical Structure

HY-14188S

Amiodarone-d4 hydrochloride

Amiodarone-d₄ (hydrochloride) is the deuterium labeled Amiodarone hydrochloride. Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC₅₀ of ～45 nM . Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts . Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias .

HY-B1272AS

Desipramine-d4

Desipramine-d₄ is the deuterium labeled Desipramine (HY-B1272A). Desipramine is a first-generation tricyclic antidepressant. Desipramine selectively binds to norepinephrine transporter and blocks neuronal norepinephrine reuptake. Desipramine activates MAPK signaling via ERK1/2, JNK, and p38, represses NF-κB and AP-1 activity, and induces apoptosis via ROS elevation, mitochondrial membrane potential reduction, and intracellular calcium increase. Desipramine also shows anyi-inflammatory activity, inhibiting TNF-α production. Desipramine can be used for the research of hepatocellular cancer, inflammation, and neurological diseases .

HY-B1272AS1

Desipramine-d3

Desipramine-d₃ is the deuterium labeled Desipramine (HY-B1272A). Desipramine is a first-generation tricyclic antidepressant. Desipramine selectively binds to norepinephrine transporter and blocks neuronal norepinephrine reuptake. Desipramine activates MAPK signaling via ERK1/2, JNK, and p38, represses NF-κB and AP-1 activity, and induces apoptosis via ROS elevation, mitochondrial membrane potential reduction, and intracellular calcium increase. Desipramine also shows anyi-inflammatory activity, inhibiting TNF-α production. Desipramine can be used for the research of hepatocellular cancer, inflammation, and neurological diseases .

HY-G0007S

Omeprazole sulfone-d3

Omeprazole sulfone-d₃ is the deuterium labeled Omeprazole sulfone. Omeprazole sulfone (Omeprazole sulphone) is one of the major circulating metabolites of Omeprazole (HY-B0113) in vivo, and belongs to class 4 non-mutagenic impurities. Omeprazole sulfone does not bind to the aryl hydrocarbon receptor (AhR), nor does it induce the expression of CYP1A1 or CYP1A2. However, Omeprazole sulfone promotes the migration of gastric epithelial cells under basal conditions and reverses the inhibitory effect of Indomethacin (HY-14397) on cell migration. Omeprazole sulfone does not promote cell proliferation, nor does it upregulate COX-2 expression or activate signaling pathways such as ERK, P38 MAPK and PI3K. Omeprazole sulfone maintains basal ulcer healing under non-acid-dependent conditions and can be used in studies related to gastric ulcer repair .

HY-G0007S1

Omeprazole sulfone-13C,d3

Omeprazole sulfone- ¹³C,d₃ is the deuterium and ¹³C labeled Omeprazole sulfone. Omeprazole sulfone (Omeprazole sulphone) is one of the major circulating metabolites of Omeprazole (HY-B0113) in vivo, and belongs to class 4 non-mutagenic impurities. Omeprazole sulfone does not bind to the aryl hydrocarbon receptor (AhR), nor does it induce the expression of CYP1A1 or CYP1A2. However, Omeprazole sulfone promotes the migration of gastric epithelial cells under basal conditions and reverses the inhibitory effect of Indomethacin (HY-14397) on cell migration. Omeprazole sulfone does not promote cell proliferation, nor does it upregulate COX-2 expression or activate signaling pathways such as ERK, P38 MAPK and PI3K. Omeprazole sulfone maintains basal ulcer healing under non-acid-dependent conditions and can be used in studies related to gastric ulcer repair .

Host:	Mouse (4) Rabbit (3)
Reactivity:	Human (7) Rat (3) Mouse (7) Monkey (3) Rabbit (2)
Application:	IHC-P (6) ICC/IF (6) IF-Tissue (1) IHC-F (1) WB (7) FC (4) ELISA (4)
Isotype:	IgG (3) IgG2a (2) IgG2b (2)
Conjugation:	Non-conjugated (7)
Clonality:	Monoclonal (4) Recombinant (2)
Modification:	Unmodified (5)

Cat. No.	Compare	상품명	Application	Reactivity	Image

HY-P87386

	p38 beta/MAPK11 + p38 gamma/MAPK12 + p38 delta/MAPK13 Antibody (YA7069) ERK 6 antibody; ERK-6 antibody; ERK6 antibody; Extracellular signal-regulated kinase 6 antibody; MAP kinase 12 antibody; MAP kinase p38 gamma antibody; MAPK 12 antibody; Mapk12 antibody; Mitogen Activated Protein Kinase 12 antibody; Mitogen activated protein kinase p38 gamma antibody	WB	Human, Mouse, Rat, Monkey
	p38 beta/MAPK11 + p38 gamma/MAPK12 + p38 delta/MAPK13 Antibody (YA7069) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p38 beta/MAPK11 + p38 gamma/MAPK12 + p38 delta/MAPK13.

HY-P87165

	p38 gamma/MAPK12 Antibody (YA6858) ERK 6 antibody; ERK-6 antibody; ERK6 antibody; Extracellular signal-regulated kinase 6 antibody; MAP kinase 12 antibody; MAP kinase p38 gamma antibody; MAPK 12 antibody; Mapk12 antibody; Mitogen Activated Protein Kinase 12 antibody; Mitogen activated protein kinase p38 gamma antibody; ERK 6 antibody; ERK-6 antibody; ERK6 antibody; Extracellular signal-regulated kinase 6 antibody; MAP kinase 12 antibody; MAP kinase p38 gamma antibody; MAPK 12 antibody; Mapk12 antibody; Mitogen Activated Protein Kinase 12 antibody; Mitogen activated protein kinase p38 gamma antibody; Mitogen-activated protein kinase 12 antibody; Mitogen-activated protein kinase p38 gamma antibody; MK12_HUMAN antibody; p38 GAMMA antibody; p38GAMMA antibody; PRKM12 antibody; SAPK 3 antibody; SAPK-3 antibody; SAPK3 antibody; Stress Activated Protein Kinase 3 antibody; Stress-activated protein kinase 3 antibody;	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	p38 gamma/MAPK12 Antibody (YA6858) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p38 gamma/MAPK12.

HY-P84236

	ERK2 Antibody (YA3933) ERK; p38; p40; p41; ERT1; MAPK2; PRKM1; P42MAPK; p41mapk; MAPK1	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Monkey
	ERK2 Antibody (YA3933) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to ERK2.

HY-P84237

	ERK1/2 Antibody (YA3934) ERK; p38; p40; p41; ERK2; ERT1; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; MAPK1	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rabbit
	ERK1/2 Antibody (YA3934) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to ERK1/2.

HY-P84236A

	ERK2 Antibody (YA3933)(PBS only) ERK; p38; p40; p41; ERT1; MAPK2; PRKM1; P42MAPK; p41mapk; MAPK1	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Monkey
	ERK2 Antibody (YA3933) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to ERK2.

HY-P84237A

	ERK1/2 Antibody (YA3934)(PBS only) ERK; p38; p40; p41; ERK2; ERT1; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; MAPK1	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rabbit
	ERK1/2 Antibody (YA3934) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to ERK1/2.

HY-P86654

	ERK1/2 Antibody (YA6346) ERK1+ERK2; ERK 1; ERK 2; ERK-2; ERK1; ERK2; ERT1; ERT2; Extracellular signal regulated kinase 1; Extracellular signal regulated kinase 2; Extracellular signal-regulated kinase 2; HS44KDAP; HUMKER1A; Insulin stimulated MAP2 kinase; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAP kinase isoform p44; MAPK 1; MAPK 2; MAPK 3; MAPK1; MAPK2; MAPK3; MGC20180; Microtubule associated protein 2 kinase; Mitogen activated protein kinase 1; Mitogen activated protein kinase 2; Mitogen activated protein kinase 3; Mitogen-activated protein kinase 1; Mitogen-activated protein kinase 2; MK01_HUMAN; MK03_HUMAN; p38; p40; p41; p41mapk; p42 MAPK; p42-MAPK; p42MAPK; p44 ERK1; p44 MAPK; p44ERK1; p44MAPK; PRKM 1; PRKM 2; PRKM 3; PRKM1; PRKM2; PRKM3; Protein kinase mitogen activated 1; Protein kinase mitogen activated 2; Protein kinase mitogen activated 3; Protein tyrosine kinase ERK 2.	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, FC	Human, Mouse, Rat
	ERK1/2 Antibody (YA6346) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERK1/2.

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p38/ERK

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