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phospholipases

" in MedChemExpress (MCE) Product Catalog:

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Oligonucleotides:	Phospholipids (3)

268

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
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Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0470

Neomycin sulfate Maximum Cited Publications 68 Publications Verification	Environmental Pollutants Antibiotic Phospholipase Bacterial	Infection Metabolic Disease Cancer
Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both the nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. Neomycin sulfate inhibits IP3-mediated Ca ²⁺ release, MgATP-dependent Ca ²⁺ uptake, and electrical excitation-evoked skeletal muscle Ca ²⁺ transients. Neomycin sulfate depletes gut microbiota in specific mouse models, causes hearing impairment, and kidney damage with prolonged exposure. Neomycin sulfate can be used for the research of cancer .

HY-13419

U-73122 Maximum Cited Publications 98 Publications Verification	Phospholipase Lipoxygenase Ferroptosis	Inflammation/Immunology
U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC₅₀of 1-2.1 µM for PLC.

HY-70072

D609 5+ Cited Publications	Phospholipase	Infection Inflammation/Immunology Cancer
D609, an antitumoural xanthate, is a specific and competitive *phosphatidyl choline-specific phospholipase* C (PC-PLC) inhibitor with a K_i** of 6.4 μM. D609 is an antioxidative protector and has antiviral and anti-inflammatory activity .

HY-P2812

Phospholipase D, Streptomyces chromofuscus PLD	Phospholipase	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Phospholipase D, Streptomyces chromofuscus (PLD) is an enzyme of the phospholipase superfamily, which widely exists in bacteria, yeast, plants, animals and viruses, and is often used in biochemical research. Phospholipase D can catalyze the hydrolysis of phosphodiester bonds in glycerophospholipids to produce phosphatidic acid and soluble choline. Phospholipase D is involved in a variety of disease-related processes, including diabetes, atherogenesis, obesity, tumorigenesis, immune response, and neuroendocrine function .

HY-W019838

D-Erythro-dihydrosphingosine 1 Publications Verification Sphinganine (d18:0)	Endogenous Metabolite Phospholipase	Cancer
D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A₂α (cPLA₂α) activity.

HY-P3029

Phospholipase A2 1 Publications Verification PLA2	Phospholipase	Cardiovascular Disease Inflammation/Immunology
Phospholipase A2 (PLA2) is a calcium-dependent, heat-stable enzyme that catalyzes the hydrolysis of glycerophospholipids at the sn-2 position of cellular membranes, thereby releasing Arachidonic Acid (AA) (HY-109590). Phospholipase A2 is a key mediator in the biosynthesis of pro-inflammatory lipid mediators, critically involved in inflammatory processes. Phospholipase A2 can be used for cardiovascular and inflammatory diseases research .

HY-12598A

DHPG 4 Publications Verification (RS)-3,5-DHPG	mGluR	Neurological Disease
DHPG is the agonist for mGluR 1/5 (EC₅₀ for mGluR 1 is 60 nM) that activates the phospholipase C (PLC) pathway, and leads ultimately to the activation of protein kinase C (PKC) .

HY-136177

Tris(2,4-di-tert-butylphenyl)phosphate	Phospholipase	Inflammation/Immunology
Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for *secretory Phospholipase* A₂ (sPLA₂**) through molecular docking .

HY-111376

Pyrrophenone 4 Publications Verification	Phospholipase	Cardiovascular Disease Inflammation/Immunology
Pyrrophenone is a potent and specific cytosolic phospholipase A₂α (cPLA₂α) inhibitor with an IC₅₀ value of 4.2 nM .

HY-N9480

Vinaxanthone 3 Publications Verification SM-345431	Phospholipase Bacterial	Infection Cancer
Vinaxanthone (SM-345431) is a potent and selective semaphorin3A, phospholipase C (PLC) and FabI inhibitor, with IC₅₀s of 0.1-0.2 μM and 0.9 mM for semaphorin3A and FabI. Vinaxanthone inhibits the substrate (t-o-NAC thioester) and the cofactor (NADPH) with K_is of 3.1 μM and 1.0 μM, respectively. Vinaxanthone can be used to handle infections caused by multidrug-resistant pathogens .

HY-W039315

2,5-Anhydro-D-mannitol, 97%	Biochemical Assay Reagents	Metabolic Disease
2,5-Anhydro-D-mannitol, 97% is an antimetabolic fructose analogue. 2,5-Anhydro-D-mannitol, 97% depletes intracellular ATP, reduces oxygen consumption, regulates substrate oxidation, increases phosphomonoester levels, decreases inorganic phosphate levels, and promotes the release of intracellular calcium from intracellular calcium stores via phospholipase C-dependent activity in hepatocytes .

HY-150520

Neomycin	Antibiotic Phospholipase	Infection Cancer
Neomycin, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin is a known phospholipase C (PLC) inhibitor. Neomycin potently inhibits both the nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. Neomycin inhibits IP3-mediated Ca ²⁺ release, MgATP-dependent Ca ²⁺ uptake, and electrical excitation-evoked skeletal muscle Ca ²⁺ transients. Neomycin depletes gut microbiota in specific mouse models, causes hearing impairment, and kidney damage with prolonged exposure. Neomycin can be used for the research of cancer .

HY-17448

Varespladib methyl 1 Publications Verification A-002; LY333013	Phospholipase	Inflammation/Immunology
Varespladib methyl (A-002; LY333013) is a selective inhibitor of group II secretory phospholipase A2 (PLA2).

HY-18540

KT109 1 Publications Verification	MAGL DAGL	Metabolic Disease Inflammation/Immunology
KT109 is a potent and an isoform-selective inhibitor of *diacylglycerol lipase-β (DAGLβ)* with an IC₅₀ of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGLα. KT109 shows inhibitory activity against PLA2G7 (IC₅₀=1 µM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-Arachidonoylglycerol (HY-W011051), Arachidonic acid (HY-109590) and eicosanoids in mouse peritoneal macrophages .

HY-N1393

2-Methoxybenzoic acid NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether	Carbonic Anhydrase Phospholipase	Cardiovascular Disease
2-Methoxybenzoic acid (NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether) is a natural compound with potential salicylate-like effect. 2-Methoxybenzoic acid inhibits carbonic anhydrase activity, elevates intraplatelet cyclic guanosine monophosphate level, and suppresses cytosolic phospholipase A₂ phosphorylation. 2-Methoxybenzoic acid suppresses platelet reactivity, including decreased spreading, retraction, and aggregation in platelets. 2-Methoxybenzoic acid ameliorates arterial thrombosis in a dose-dependent manner without affecting normal hemostasis in mice. 2-Methoxybenzoic acid can be used for the research of arterial thrombosis .

HY-111919

3-Nitrocoumarin 3 Publications Verification	Phospholipase Fungal	Infection
3-Nitrocoumarin is an inhibitor for phospholipase C that blocks the generation of inositol triphosphate (IP₃), thereby affecting the calcium signaling pathway .

HY-108607

PACOCF3 Palmityltrifluoromethylketone	Phospholipase	Inflammation/Immunology
PACOCF3 (Palmityltrifluoromethylketone) is a selective phospholipase A2 inhibitor with an IC₅₀ of 3.8 μM. PACOCF3 alters Ca ²⁺ signaling in renal tubular cells .

HY-19151

Fuzapladib IS-741	Integrin Phospholipase	Inflammation/Immunology
Fuzapladib (IS-741), an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site .

HY-100983

Protein kinase inhibitor H-7 dihydrochloride	PKC	Cancer
Protein kinase inhibitor H-7 dihydrochloride is a potent PKC (protein kinase C) inhibitor. At 100 μM, Protein kinase inhibitor H-7 dihydrochloride completely inhibits both TPA (skin tumour promoter, 12-O-tetradecanoylphorbol-13-acetate) and phospholipase C-induced ODC (ornithine decarboxylase) .

HY-119019

ASB14780 1 Publications Verification	Phosphatase	Inflammation/Immunology
ASB14780 is a 4-phenoxy derivative, the *cytosolic Phospholipase* A₂α (cPLA₂α) inhibitor, with an IC₅₀** value of 20 nM .

HY-14952

Giripladib PLA-695	Phospholipase	Inflammation/Immunology Cancer
Giripladib (PLA-695) is a indole-based inhibitor of *cytosolic phospholipase* A₂ (cPLA₂)**. Giripladib can be used for osteoarthritis and breast cancer research .

HY-N1773

5,7,3'-Tri-O-methyl (-)-epicatechin	Others	Cancer
5,7,3' -tri-O-Methyl (-)-epicatechin (Compound 13) is a phospholipase Cγ1 (PLCγ1) inhibitor. 5,7,3' -tri-o-methyl (-)-epicatechin has a methylene dioxy benzene ring and can express inhibitory activity against PLCγ1. 5,7,3' -tri-O-Methyl (-)-epicatechin can be used in the study of chemotherapy and chemopexic agents for cancer .

HY-P2812A

Phospholipase D, peanut	Endogenous Metabolite	Metabolic Disease
Phospholipase D, peanut is an important signaling enzyme in mammalian cells. Phospholipase D, peanut catalyzes the hydrolysis of phosphatidylcholine to produce phosphatidic acid (PA) and choline .

HY-P10447

Plipastatin A1 Fengycin IX; SNA-60-367-3	Phospholipase Fungal	Infection
Plipastatin A1 (Fengycin IX; SNA-60-367-3) is a lipopeptide with phospholipase A2 inhibitory activity. Plipastatin A1 inhibits conidial germination of Botrytis cinerea in vitro and reduces the incidence of gray mold on tomato leaves. Plipastatin A1 is applicable to research related to gray mold ^[1][2].

HY-P3029A

Phospholipase A2, Crotalus adamanteus Venom PLA2, Crotalus adamanteus Venom	Phospholipase	Others
Phospholipase A2, Crotalus adamanteus Venom (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA). Phospholipase A2, Crotalus adamanteus Venom is a member of the class of heat-stable, calcium-dependent enzymes, is often used in biochemical studies .

HY-108609

YM-26734	Phospholipase	Inflammation/Immunology
YM-26734 is a competitive inhibitor of secretory phospholipase A ² (PLA ²) that exhibits a broad inhibitory profile to several PLA2s .

HY-W100403

Choline tosylate Choline p-toluenesulfonate	Phospholipase	Others
Choline tosylate (Choline p-toluenesulfonate) is an intermediate and also a substrate of choline acetyltransferase (CHAT). Choline tosylate inhibits phospholipase A2 and phospholipase C .

HY-122756

N-Palmitoyl-l-leucine GK144	Phospholipase	Inflammation/Immunology
N-Palmitoyl-l-leucine (GK144) is a *secreted phospholipases* A₂** inhibitor. N-Palmitoyl-l-leucine can be used for inflammatory diseases .

HY-107393

LY-311727	Phospholipase	Inflammation/Immunology
LY-311727 is a potent *secretory non-pancreatic phospholipase* A₂ (sPLA₂)** inhibitor (IC₅₀ <1 μM for group IIA sPLA₂). sPLA₂ is an important proinflammatory enzyme .

HY-P2705

Mastoparan X	Endogenous Metabolite	Others
Mastoparan X is a GTP-binding regulatory protein (G protein)-activating peptide, and a tetradecapeptide from wasp venom. Mastoparan X acts function by the direct activation of G protein that couple to phospholipase C to cause secretion from various kinds of cells .

HY-116301

CAY10502	Phospholipase	Inflammation/Immunology
CAY10502 is a potent, calcium-dependent *cytosolic phospholipase* A2 α (cPLA₂α) inhibitor with an IC₅₀** of 4.3 nM for isolated enzyme. CAY10502 can be used in the research of retinopathy and inflammatory diseases .

HY-19151A

Fuzapladib sodium IS-741 sodium	Integrin Phospholipase	Inflammation/Immunology
Fuzapladib (IS-741) sodium, an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib sodium is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib sodium exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site .

HY-145653

GSK2647544	Phospholipase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
GSK2647544 is an orally available, selective inhibitor of Lp-PLA2. Lipoprotein-associated phospholipase (Lp-PLA2) is a calcium-independent phospholipase A2 with proinflammatory activities that is primarily secreted by monocyte-derived macrophages .

HY-W612338

9-Oxononanoic acid 9-ONA	Acetyl-CoA Carboxylase	Inflammation/Immunology
9-Oxononanoic acid (9-ONA) is an orally active acetyl-CoA carboxylase inhibitor. 9-Oxononanoic acid inhibits acetyl-CoA carboxylase via accumulation of long-chain acyl-CoA. 9-Oxononanoic acid increases carnitine palmitoyltransferase, isocitrate dehydrogenase and glucose 6-phosphate dehydrogenase activity to elevate β-oxidation and support NADPH (HY-113324) supplyactivity. 9-Oxononanoic acid stimulates phospholipase A2 activity via post-translational, non-transcriptional mechanisms. 9-Oxononanoic acid can be used for the research of atherothrombosis .

HY-120441

CAY10590 GK115	Phospholipase Prostaglandin Receptor	Inflammation/Immunology
CAY10590 (GK115) is an inhibitor of *secreted phospholipase* A₂ (sPLA₂**) and can be used for the research of chronic inflammatory kidney diseases .

HY-70083

SPK-601 LMV-601	Phospholipase Reverse Transcriptase	Infection
SPK-601 (LMV-601) is an inhibitor of the *phosphatidylcholine-specific phospholipase* C (PC-PLC)**. SPK-601 also can be used as an antimicrobial agent .

HY-P2817

Phospholipase C PLCs	Phospholipase	Infection Metabolic Disease
Phospholipase C (PLCs) is a class of phospholipases. Phospholipase C participates in cellular signaling and regulation by virtue of its ability to hydrolyze membrane phospholipids into di-acyl-glycerol (DAG) and inositol triphosphate (IP3), which further causes the activation of other signaling pathways involved in various processes, including immune response .

HY-155342

A3373	Phospholipase	Inflammation/Immunology
A3373, a novel chemical inhibitor of *Phospholipase* D1 (PLD1) and PLD2, with IC₅₀ of 325 nM and 15.15?μM, respectively, inhibits LPS-induced immune response and plays important roles in autoimmune arthritis, bone demineralization and osteoclastogenesis .

HY-145384

ROC-0929	Phospholipase	Inflammation/Immunology
ROC-0929 (compound 13a) is a potent and selective inhibitor of *secreted phospholipases* A₂ (sPLA₂s) with an IC₅₀ of 80 nM, specially targeting hGX. ROC-0929 inhibits the phosphorylation of ERK1/2 and p-38. Secreted phospholipases A2 (sPLA2s)** are a family of disulfide-rich, Ca ²⁺-dependent enzymes that hydrolyze the sn-2 position of glycero-phospholipids to release a fatty acid and a lysophospholipid. ROC-0929 has the potential for researching inflammation related diseases .

HY-116018

FKGK11	Phospholipase	Neurological Disease Inflammation/Immunology Cancer
FKGK11 is a potent and selective inhibitor of GVIA iPLA2 (Group VIA calcium-independent phospholipase A2). FKGK11 can be used for the research of ovarian cancer and neurological disorders such as peripheral nerve injury and multiple sclerosis .

HY-P10053

sPLA2-IIA Inhibitor	Phospholipase	Metabolic Disease
sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids .

HY-129944

MJ33-OH	Phospholipase	Inflammation/Immunology
MJ33-OH is a metabolite of MJ33. MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6 .

HY-125157

Me-Indoxam	Phospholipase	Inflammation/Immunology
Me-Indoxam is a potent and cell-impermeable secreted phospholipase A₂ (sPLA₂) inhibitor .

HY-P2812B

Phospholipase D, cabbage	Phospholipase	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Phospholipase D, cabbage is an enzyme of the phospholipase superfamily. Phospholipase D, cabbage is widely found in bacteria, yeast, plants, animals and viruses and is often used in biochemical research. Phospholipase D, cabbage can catalyze the hydrolysis of the phosphodiester bond of glycerophospholipids to produce phosphatidic acid and soluble choline. Phospholipase D, cabbage is involved in a variety of disease-related processes, including diabetes, atherosclerosis, obesity, tumorigenesis, immune response and neuroendocrine function .

HY-148388

N-Stearoylsphingomyelin N-Stearoyl-D-sphingomyelin	Phospholipase	Cancer
N-Stearoylsphingomyelin (N-Stearoyl-D-sphingomyelin) is a sphingolipid, which can inhibit Phospholipase Cδ1 (PLCδ1) .

HY-19920

AVX001 AKH-217	Phospholipase	Inflammation/Immunology
AVX001 is an inhibitor of phospholipase A2 (cPLA2α) that can be used in the research of psoriasis .

HY-117168

1,2-Dilinoleoyl-sn-glycerol	Endogenous Metabolite	Metabolic Disease
1,2-Dilinoleoyl-sn-glycerol is a diacylglycerol (DAG) with linoleic acid (HY-N0729) (18:2) side chains attached at both the sn-1 and sn-2 positions . 1,2-Dilinoleoyl-sn-glycerol can be prepared from L-dilinoleoylphosphatidylcholine via hydrolysis with phospholipase C .

HY-118994

ARN19874	Phospholipase	Neurological Disease
ARN19874 is a selective, reversible uncompetitive N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) activity inhibitor with an IC₅₀ of ~34 μM .

HY-137311

(S)-Albuterol hydrochloride	Calcium Channel Phospholipase mAChR	Neurological Disease
(S)-Albuterol hydrochloride is a muscarinic receptor and phospholipase C activator. (S)-Albuterol hydrochloride increases intracellular free calcium in airway smooth muscle .

HY-N1450

Aristolochic acid C	Phospholipase	Cancer
Aristolochic acid C is a derivative of Aristolochic acid. Aristolochic acid is a phospholipase A₂ (PLA2) inhibitor, which disrupts cortical microtubule arrays and root growth in Arabidopsis .

Cat. No.	Product Name	Type

HY-100045

p-Nitrophenyl phosphorylcholine 4-Nitrophenylphosphorylcholine; 4-Nitrophenylphosphorylcholine; O-(4-Nitrophenylphosphoryl)choline	Fluorescent Dye
p-Nitrophenyl phosphorylcholine (4-Nitrophenylphosphorylcholine) is a chromogenic substrate that is used to measure phospholipase C (PLC) activity. Hydrolysis of p-nitrophenylphosphorylcholine by PLC results in the liberation of p-nitrophenol, which can be measured at 405 nm at pH 7.2-7.5.

HY-D1647

7-Hydroxycoumarinyl-γ-linolenate	Fluorescent Dye
7-Hydroxycoumarinyl-γ-linolenate is a cytosolic phospholipase A₂ (cPLA₂) fluorogenic substrate. 7-Hydroxycoumarinyl-γ-linolenate can be used to monitor the enzymatic activity of cPLA₂ .

HY-W713925

Diheptanoyl Thio-PC	Fluorescent Dye
Diheptanoyl Thio-PC is a substrate for all phospholipase A2s (PLA2s) with the exception of cPLA2 and PAF-acetyl hydrolase (PAF-AH).1 Interaction of this compound with a PLA2 results in cleavage of the sn-2 fatty acid generating a free thiol on the lysophospholipid. This free thiol can be detected using chromogenic substrates such as DTNB (Ellman’s reagent) and DTP.

Cat. No.	Product Name	Type

HY-100168

BAPTA Maximum Cited Publications 36 Publications Verification	Biochemical Assay Reagents
BAPTA is a selective and cell-impermeant chelator for calcium. BAPTA has high selectivity against magnesium and calcium. BAPTA can also inhibit phospholipase C activity independently of their role as Ca ²⁺ chelators .

HY-W039315

2,5-Anhydro-D-mannitol, 97%	Biochemical Assay Reagents
2,5-Anhydro-D-mannitol, 97% is an antimetabolic fructose analogue. 2,5-Anhydro-D-mannitol, 97% depletes intracellular ATP, reduces oxygen consumption, regulates substrate oxidation, increases phosphomonoester levels, decreases inorganic phosphate levels, and promotes the release of intracellular calcium from intracellular calcium stores via phospholipase C-dependent activity in hepatocytes .

HY-NP159

House Dust Mite Extract, from D.farinae

Biochemical Assay Reagents

House Dust Mite Extract, from D.farinae is a house dust mite allergen extract derived from Dermatophagoides farinae. House Dust Mite Extract, from D.farinae significantly increases the levels of cytokines (IL-4, IL-5, IL-6) in bronchoalveolar lavage fluid. House Dust Mite Extract, from D.farinae upregulates the overexpression of MUC5AC. House Dust Mite Extract, from D.farinae induces allergic asthma and pulmonary inflammation .

HY-148123

Glycerophospholipids, cephalins

Biochemical Assay Reagents

Glycerophospholipids and cephalins are a class of phospholipid compounds and important components of neural membranes. Glycerophospholipids and cephalins are hydrolysis substrates of phospholipase (such as PLA2, PLC, and PLD). After complete hydrolysis, they produce 1 mol of glycerol, phosphate, ethanolamine, and 2 mol of fatty acids, respectively. Glycerophospholipids and cephalins can maintain membrane structure, fluidity, and ion permeability, and serve as precursors of second messengers such as arachidonic acid and diacylglycerol. Glycerophospholipids and cephalins can regulate signal transduction, cell apoptosis, and membrane transport, and are used in the study of neurodegenerative diseases (such as Alzheimer's disease) .

HY-100168B

BAPTA tetrapotassium Maximum Cited Publications 36 Publications Verification	Biochemical Assay Reagents
BAPTA tetrapotassium is a selective and cell-impermeant chelator for calcium. BAPTA has high selectivity against magnesium and calcium. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca ²⁺ chelators .

HY-W100403

Choline tosylate Choline p-toluenesulfonate	Biochemical Assay Reagents
Choline tosylate (Choline p-toluenesulfonate) is an intermediate and also a substrate of choline acetyltransferase (CHAT). Choline tosylate inhibits phospholipase A2 and phospholipase C .

HY-W329357

15:0 Lyso PC

1 Publications Verification

Biochemical Assay Reagents

15:0 Lyso PC is a lysophosphatidylcholine (Lyso PC), a product of phospholipase A2 (PLA2) hydrolysis of phosphatidylcholine (PC) and is involved in cell membrane remodeling and inflammatory signaling. 15:0 Lyso PC demonstrates significant lipid metabolism disturbances in the serum with ischemic heart disease (IHD) and ischemic cardiomyopathy (ICM). 15:0 Lyso PC can be used as a lipid biomarker for cardiovascular disease .

HY-W127380

Arachidonoyl thio-PC

Biochemical Assay Reagents

Arachidonoyl Thio-PC is a substrate of many phospholipase A2 (PLA2), including sPLA2, cPLA2 and iPLA2. Cleavage of sn-2 fatty acids by PLA2 results in the production of free thiols, which react with chromogenic reagents such as DTNB (Ellman's reagent) and DTP, allowing quantification of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by depleting or inhibiting sPLA2 and iPLA2 activity in the assay.

HY-W414749

08:0 Lyso PC 1-Octanoyl-sn-glycero-3-phosphocholine	Biochemical Assay Reagents
08:0 Lyso PC (1-Octanoyl-sn-glycero-3-phosphocholine) is a lysolecithin that can be hydrolyzed by Phospholipase A2 (HY-P3029) .

HY-100168R

BAPTA (Standard)

Biochemical Assay Reagents

BAPTA (Standard) is the analytical standard of BAPTA. This product is intended for research and analytical applications. BBAPTA is a selective and cell-impermeant chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA is widely used as an intracellular buffer for investigating the effects of Ca ²⁺ release from intracellular stores or influx via Ca ²⁺-permeable channels in the plasma membrane. BAPTA can also inhibit phospholipase C activity independently of their role as Ca ²⁺ chelators .

HY-157718

1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine

Biochemical Assay Reagents

1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine is a surfactant that has the activity of promoting liposome formation. 1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine can effectively study the biological effects of ceramide and ceramide phosphate. 1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine shows important application in the determination of phospholipase A activity of lecithin-cholesterol acyltransferase in ether matrix.

HY-100168BR

BAPTA tetrapotassium (Standard)

Biochemical Assay Reagents

BAPTA tetrapotassium (Standard) is the analytical standard of BAPTA tetrapotassium (HY-100168B). This product is intended for research and analytical applications. BAPTA tetrapotassium is a selective and cell-impermeant chelator for calcium. BAPTA tetrapotassium, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrapotassium is widely used as an intracellular buffer for investigating the effects of Ca ²⁺ release from intracellular stores or influx via Ca ²⁺-permeable channels in the plasma membrane. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca ²⁺ chelators .

Cat. No.	Product Name	Target	Research Area

HY-P10447

Plipastatin A1 Fengycin IX; SNA-60-367-3	Phospholipase Fungal	Infection
Plipastatin A1 (Fengycin IX; SNA-60-367-3) is a lipopeptide with phospholipase A2 inhibitory activity. Plipastatin A1 inhibits conidial germination of Botrytis cinerea in vitro and reduces the incidence of gray mold on tomato leaves. Plipastatin A1 is applicable to research related to gray mold ^[1][2].

HY-P1341

OXA(17-33) Orexin A (17-33) (human, mouse, rat, bovine)	Orexin Receptor (OX Receptor) Sigma Receptor Phospholipase	Neurological Disease
OXA (17-33) (Orexin A (17-33) (human, mouse, rat, bovine)) is the shortest active orexin peptide that selectively targets OX1 (EC₅₀=8.29 nM), with 23-fold selectivity for the OX1 receptor over the OX2 receptor. The activity of OXA (17-33) depends on the Tyr17, Leu20, Asn25, His26 residues and the spatial conformation of the α-helix. OXA (17-33) activates signaling pathways involving inositol-1,4,5-trisphosphate receptor (IP3R), phospholipase D (PL-D) and choline-Sigma-1R, thereby increasing the cytoplasmic Ca ²⁺ level in nucleus accumbens neurons, an effect that is blocked by Sigma-1R antagonists. OXA (17-33) serves as an important biological probe for investigating the function of the OX1 receptor. OXA (17-33) can be modified via incorporation of mixed disulfide bonds of homocysteine and cysteamine, and is widely used in studies related to insomnia and narcolepsy .

HY-P2705

Mastoparan X	Endogenous Metabolite	Others
Mastoparan X is a GTP-binding regulatory protein (G protein)-activating peptide, and a tetradecapeptide from wasp venom. Mastoparan X acts function by the direct activation of G protein that couple to phospholipase C to cause secretion from various kinds of cells .

HY-P10053

sPLA2-IIA Inhibitor	Phospholipase	Metabolic Disease
sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids .

HY-P3906

Melittin free acid	Fungal Apoptosis Phospholipase Reactive Oxygen Species (ROS)	Infection
Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways .

HY-113560

Plipastatin B1	Antibiotic Fungal Phospholipase	Infection
Plipastatin B1 is a lipopeptide antibiotic, an inhibitor of phospholipase A₂ (PLA2), which has antifungal activity .

HY-P10658

ARF1 (2-17)	Phospholipase	Others
ARF1 (2-17) inhibits both ARF-independent (PLC-β) and ARF-dependent (PLD) pathways. ARF1 (2-17) inhibits GTP-γ-S-stimulated PLD activity, phospholipase C-β (PLC-β), and exocytosis .

HY-P1834

MARCKS Peptide(151-175), Phosphorylated	Peptides	Inflammation/Immunology
MARCKS Peptide(151-175), Phosphorylated is a phosphorylated peptide corresponding to the basic effector domain of myristoylated alanine-rich protein kinase C substrate protein (MARCKS). Phosphorylation of MARCKS Peptide (151-175) reverses its inhibition of phospholipase C (PLC)-catalyzed hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) .

HY-P2139

Ranakinin	Neurokinin Receptor Phospholipase	Others
Ranakinin is a NK1R agonist. Ranakinin inhibits the binding of selective NK1 radioligands to NK1 receptors. Ranakinin activates phospholipase C (Phospholipase C), thereby enhancing polyphosphoinositide hydrolysis. Ranakinin stimulates inositol phosphate production and reduces membrane polyphosphoinositide levels. Ranakinin stimulates corticosterone and aldosterone secretion .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99505

Ziltivekimab COR-001; MEDI-5117; MEDI-5117; NN-6018; WBP-216	Interleukin Related LDLR	Inflammation/Immunology Endocrinology
Ziltivekimab (COR-001) is a fully human monoclonal antibody and also an IL-6 inhibitor. Ziltivekimab significantly reduces inflammatory biomarkers and Lipoprotein (a) in chronic kidney disease patients with systemic inflammation. Ziltivekimab does not increase pro-atherosclerotic lipid levels. Ziltivekimab is used in studies related to atherosclerotic thrombotic diseases and chronic kidney disease .

HY-P991964

Rendomab B4 Rendomab-B49	Endothelin Receptor	Cancer
Rendomab B4 is a monoclonal antibody targeting ETB. Rendomab B4 preferentially binds to ETB in the active conformational state and exhibits selectivity for ETB on melanoma cells. Rendomab B4 inhibits the G protein-dependent phospholipase C (PLC) pathway, blocks ET-3-induced Gαi/o-mediated inhibition of adenylate cyclase, and does not affect the activation of the ERK1/2 pathway. Rendomab B4 is applicable to melanoma-related research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0470

Neomycin sulfate Maximum Cited Publications 68 Publications Verification	Structural Classification Classification of Application Fields Antibacterial Disease Research Other Antibiotics Infection Microorganisms Antibiotics Animal Husbandry Mammalian Cell Culture Anticancer Disease Research Fields Source Classification	Environmental Pollutants Antibiotic Phospholipase Bacterial
Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both the nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. Neomycin sulfate inhibits IP3-mediated Ca ²⁺ release, MgATP-dependent Ca ²⁺ uptake, and electrical excitation-evoked skeletal muscle Ca ²⁺ transients. Neomycin sulfate depletes gut microbiota in specific mouse models, causes hearing impairment, and kidney damage with prolonged exposure. Neomycin sulfate can be used for the research of cancer .

HY-W019838

D-Erythro-dihydrosphingosine 1 Publications Verification Sphinganine (d18:0)	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite Phospholipase
D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A₂α (cPLA₂α) activity.

HY-136177

Tris(2,4-di-tert-butylphenyl)phosphate	Natural Products Verbenaceae Plants Inflammation/Immunology Disease Research Fields Source Classification Vitex negundo Linn.	Phospholipase
Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for *secretory Phospholipase* A₂ (sPLA₂**) through molecular docking .

HY-N9480

Vinaxanthone 3 Publications Verification SM-345431	Microorganisms Xanthones Classification of Application Fields Phenols Disease Research Fields Cancer Source Classification	Phospholipase Bacterial
Vinaxanthone (SM-345431) is a potent and selective semaphorin3A, phospholipase C (PLC) and FabI inhibitor, with IC₅₀s of 0.1-0.2 μM and 0.9 mM for semaphorin3A and FabI. Vinaxanthone inhibits the substrate (t-o-NAC thioester) and the cofactor (NADPH) with K_is of 3.1 μM and 1.0 μM, respectively. Vinaxanthone can be used to handle infections caused by multidrug-resistant pathogens .

HY-N7036

Rhamnetin 1 Publications Verification	Flavonols Flavonoids Classification of Application Fields Phenols Polyphenols Amberboa moschata (L.) DC. Umbelliferae Plants Inflammation/Immunology Disease Research Fields Source Classification	Phospholipase HDAC Apoptosis
Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2 and histone deacetylase 2 (HDAC2). Rhamnetin exhibits antitumor, antioxidant and anti-inflammatory activity .

HY-N1393

2-Methoxybenzoic acid NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Carbonic Anhydrase Phospholipase
2-Methoxybenzoic acid (NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether) is a natural compound with potential salicylate-like effect. 2-Methoxybenzoic acid inhibits carbonic anhydrase activity, elevates intraplatelet cyclic guanosine monophosphate level, and suppresses cytosolic phospholipase A₂ phosphorylation. 2-Methoxybenzoic acid suppresses platelet reactivity, including decreased spreading, retraction, and aggregation in platelets. 2-Methoxybenzoic acid ameliorates arterial thrombosis in a dose-dependent manner without affecting normal hemostasis in mice. 2-Methoxybenzoic acid can be used for the research of arterial thrombosis .

HY-W012595

Benzylideneacetone Benzalacetone	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Antibiotic Endogenous Metabolite Phospholipase Bacterial Tyrosinase
Benzylideneacetone (Benzalacetone) is an orally active antibiotic, tyrosinase inhibitor, phospholipase A₂ inhibitor, and immunosuppressant. Benzylideneacetone has antibacterial activity against some gram-negative plant-pathogenic bacteria. Benzylideneacetone can also be used in the synthesis of chemicals and drugs, and as a flavoring additive for some foods .

HY-N7327

Ochnaflavone	Structural Classification Flavonoids Ochna atropurpurea DC. Plants Biflavones Source Classification	Phospholipase
Ochnaflavone is an inhibitor of IIA-type secretory phospholipase A2 (sPLA2-IIA) with an IC₅₀ of 3.45 µM. Ochnaflavone exhibits significant anti-inflammatory and liver-protective effects, capable of inhibiting the degradation of phosphatidylethanolamine (PE) and lipid peroxidation induced by carbon tetrachloride (CCl4) in rat liver, with an IC₅₀ of 7.16 µM for lipid peroxidation. Ochnaflavone can be used in research on liver damage and inflammatory diseases .

HY-150524

UDP-Galactose	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite P2Y Receptor
UDP-Galactose is a monosaccharide and a key glycosyl donor molecule in cells that participates in nucleotide sugar metabolism. UDP-Galactose is the natural agonist of the P2Y₁₄ receptor coupled to G_i proteins in the immune system (IC₅₀= 0.67 μM, hP2Y₁₄). UDP-Galactose can be used to study cell signal transduction and substance metabolism .

HY-N1773

5,7,3'-Tri-O-methyl (-)-epicatechin	Machilus thunbergii Sieb. et Zucc. Flavonoids Flavanols Plants Lauraceae Source Classification	Others
5,7,3' -tri-O-Methyl (-)-epicatechin (Compound 13) is a phospholipase Cγ1 (PLCγ1) inhibitor. 5,7,3' -tri-o-methyl (-)-epicatechin has a methylene dioxy benzene ring and can express inhibitory activity against PLCγ1. 5,7,3' -tri-O-Methyl (-)-epicatechin can be used in the study of chemotherapy and chemopexic agents for cancer .

HY-114457

Phosphatidylinositol 4,5-bisphosphate L-alpha-Phosphatidylinositol-4,5-bisphosphate; (PtdIns)-(4,5)-P2	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Lipid Source Classification	Phospholipase
Phosphatidylinositol 4,5-bisphosphate (L-alpha-Phosphatidylinositol-4,5-bisphosphate) is a plasma membrane lipid that is enriched in the cytoplasmic leaflet of the plasma membrane. Phosphatidylinositol 4,5-bisphosphate serves as a substrate for phospholipase C and class I PI3K, generating diacylglycerol, inositol (1,4,5)-trisphosphate, and phosphatidylinositol (3,4,5)-trisphosphate. Phosphatidylinositol 4,5-bisphosphate contributes to lamellipodial protrusion, directional cell migration, focal adhesion lipid generation, and trafficking of the GABA_A receptor. Phosphatidylinositol 4,5-bisphosphate can be used in research related to acute lung injury and pulmonary edema .

HY-W612338

9-Oxononanoic acid 9-ONA	Structural Classification Arachis hypogaea L. Leguminosae Ketones, Aldehydes, Acids Plants Source Classification	Acetyl-CoA Carboxylase
9-Oxononanoic acid (9-ONA) is an orally active acetyl-CoA carboxylase inhibitor. 9-Oxononanoic acid inhibits acetyl-CoA carboxylase via accumulation of long-chain acyl-CoA. 9-Oxononanoic acid increases carnitine palmitoyltransferase, isocitrate dehydrogenase and glucose 6-phosphate dehydrogenase activity to elevate β-oxidation and support NADPH (HY-113324) supplyactivity. 9-Oxononanoic acid stimulates phospholipase A2 activity via post-translational, non-transcriptional mechanisms. 9-Oxononanoic acid can be used for the research of atherothrombosis .

HY-W012595A

trans-Benzylideneacetone trans-Benzalacetone	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Inflammation/Immunology Disease Research Fields Source Classification	Environmental Pollutants Phospholipase
trans-Benzylideneacetone (trans-Benzalacetone), a metabolite of gram-negative entomopathogenic bacterium Xenorhabdus nematophila, is an enzyme inhibitor against phospholipase A2 (PLA2). trans-Benzylideneacetone is an immunosuppressant .

HY-B0470R

Neomycin sulfate (Standard)	Structural Classification Microorganisms Antibiotics Animal Husbandry Mammalian Cell Culture Antibacterial Disease Research Anticancer Other Antibiotics Source Classification	Reference Standards Bacterial Antibiotic Phospholipase
Neomycin (sulfate) (Standard) is the analytical standard of Neomycin (sulfate). This product is intended for research and analytical applications. Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis .

HY-N2330

Lipstatin	Microorganisms Ketones, Aldehydes, Acids Source Classification	Lipase
Lipstatin is a pancreatic lipase inhibitor (IC₅₀=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin (<200 μM) .

HY-W654264

2-Methylbutyrylcarnitine chloride	Cardiovascular Disease Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Integrin
2-Methylbutyrylcarnitine (chloride) is a gut microbial metabolite which binds to integrin α2β1 in platelets, potentiating cytosolic phospholipase A2 (cPLA2) activation and platelet hyperresponsiveness. 2-Methylbutyrylcarnitine (chloride) enhances platelet hyperreactivity and thrombus formation in mice. 2-Methylbutyrylcarnitine (chloride) is a branched-chain acylcarnitine .

HY-N1450

Aristolochic acid C	Monophenols other families Classification of Application Fields Phenols Plants Disease Research Fields Source Classification Cancer	Phospholipase
Aristolochic acid C is a derivative of Aristolochic acid. Aristolochic acid is a phospholipase A₂ (PLA2) inhibitor, which disrupts cortical microtubule arrays and root growth in Arabidopsis .

HY-N8610

Uralsaponin D	Triterpenes Leguminosae Glycyrrhiza inflata Batal. Terpenoids Plants Source Classification	Phosphatase
Uralsaponin D is a saponin that can be isolated from Glycyrrhiza inflata. Uralsaponin D inhibits phospholipase A2 (PLA₂) with an IC₅₀ value of 32.2 μM .

HY-118725

Luffariellolide	Natural Products Classification of Application Fields Animals Disease Research Fields Inflammation/Immunology Source Classification	Phospholipase
Luffariellolide is an inhibitor of human synovial fluid phospholipase A2 (HSF-PLA2) (IC₅₀=5 μM). Luffariellolide effectively inhibits phorbol ester (PMA)-induced ear edema (ED₅₀=50 μg/ear) .

HY-136177R

Tris(2,4-di-tert-butylphenyl)phosphate (Standard)	Natural Products Verbenaceae Plants Source Classification Vitex negundo Linn.	Reference Standards Phospholipase
Tris(2,4-di-tert-butylphenyl)phosphate (Standard) is the analytical standard of Tris(2,4-di-tert-butylphenyl)phosphate. This product is intended for research and analytical applications. Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A2 (sPLA2) through molecular docking .

HY-116671

Folipastatin	Monophenols Microorganisms Classification of Application Fields Other Diseases Phenols Disease Research Fields Source Classification	Phospholipase
Folipastatin is a potent inhibitor of phospholipase A2 with an IC₅₀ of 39 μM. Folipastatin is a new depsidone compound from Aspergillus unguis .

HY-N14050

Cinatrin A	Natural Products Microorganisms Source Classification	Phospholipase
Cinatrin A has the activity of inhibiting phospholipase A2 .

HY-N14292

Hispidospermidin	Natural Products Microorganisms Source Classification	Phospholipase
Hispidospermidin is a phospholipase C inhibitor found in Chaetosphaeronema hispidulum .

HY-N14101

Cinatrin B	Natural Products Microorganisms Source Classification	Phospholipase
Cinatrin B has the activity of inhibiting phospholipase A2 .

HY-W019838R

D-Erythro-dihydrosphingosine (Standard) Sphinganine (d18:0) (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Phospholipase
D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.

HY-N14103

Cinatrin C1	Natural Products Microorganisms Source Classification	Phospholipase
Cinatrin C1 is a phospholipase A2 (PLA2) inhibitor that can be extracted from Circinotrichum falcatisporum RF-641 .

HY-N14104

Cinatrin C2	Microorganisms Antibiotics Other Antibiotics Source Classification	Phospholipase
Cinatrin C2 is a phospholipase A2 (PLA2) inhibitor with an IC₅₀ of 800 μM and can be extracted from Circinotrichum falcatisporum RF-641 .

HY-N14105

Cinatrin C3	Natural Products Microorganisms Source Classification	Phospholipase
Cinatrin C3 is a phospholipase A2 (PLA2) inhibitor with an IC₅₀ of 70 μM and can be extracted from Circinotrichum falcatisporum RF-641 .

HY-N1450R

Aristolochic acid C (Standard)	Structural Classification Monophenols other families Phenols Plants Source Classification	Reference Standards Phospholipase
Aristolochic acid C (Standard) is the analytical standard of Aristolochic acid C. This product is intended for research and analytical applications. Aristolochic acid C is a derivative of Aristolochic acid. Aristolochic acid is a phospholipase A2 (PLA2) inhibitor, which disrupts cortical microtubule arrays and root growth in Arabidopsis .

HY-N7036R

Rhamnetin (Standard)	Flavonols Structural Classification Flavonoids Phenols Polyphenols Amberboa moschata (L.) DC. Umbelliferae Plants Source Classification	Reference Standards Phospholipase HDAC Apoptosis
Rhamnetin (Standard) is the analytical standard of Rhamnetin. This product is intended for research and analytical applications. Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2 and histone deacetylase 2 (HDAC2). Rhamnetin exhibits antitumor, antioxidant and anti-inflammatory activity .

HY-W012595AR

trans-Benzylideneacetone (Standard) trans-Benzalacetone (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Reference Standards Phospholipase
trans-Benzylideneacetone (Standard) is the analytical standard of trans-Benzylideneacetone. This product is intended for research and analytical applications. trans-Benzylideneacetone (trans-Benzalacetone), a metabolite of gram-negative entomopathogenic bacterium Xenorhabdus nematophila, is an enzyme inhibitor against phospholipase A2 (PLA2). trans-Benzylideneacetone is an immunosuppressant[1].

HY-N16481

Parameritannin A-1	Apocynaceae Structural Classification Phenols Polyphenols Parameria laevigata (Juss.) Moldenke Plants Source Classification	COX Phospholipase
Parameritannin A-1 is a tetrameric proanthocyanidin (PAC) that can be isolated from the bark of Parameria laevigata Moldenke (Apocynaceae). Parameritannin A-1 is a COX-2 inhibitor. Parameritannin A-1 also inhibits the activity of phospholipase A₂ (PLA₂) .

HY-W012595R

Benzylideneacetone (Standard) Benzalacetone (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Antibiotic Bacterial Tyrosinase Phospholipase
Benzylideneacetone (Standard) is the analytical standard of Benzylideneacetone. This product is intended for research and analytical applications. Benzylideneacetone (Benzalacetone) is an orally active antibiotic, tyrosinase inhibitor, phospholipase A₂ inhibitor, and immunosuppressant. Benzylideneacetone has antibacterial activity against some gram-negative plant-pathogenic bacteria. Benzylideneacetone can also be used in the synthesis of chemicals and drugs, and as a flavoring additive for some foods .

HY-N1393R

2-Methoxybenzoic acid (Standard) NSC 3778 (Standard); O-Methylsalicylic acid (Standard); Salicylic acid methyl ether (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Carbonic Anhydrase Phospholipase
2-Methoxybenzoic acid (NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether) (Standard) is the analytical standard of 2-Methoxybenzoic acid (HY-N1393). 2-Methoxybenzoic acid is a natural compound with potential salicylate-like effect. 2-Methoxybenzoic acid inhibits carbonic anhydrase activity, elevates intraplatelet cyclic guanosine monophosphate level, and suppresses cytosolic phospholipase A₂ phosphorylation. 2-Methoxybenzoic acid suppresses platelet reactivity, including decreased spreading, retraction, and aggregation in platelets. 2-Methoxybenzoic acid ameliorates arterial thrombosis in a dose-dependent manner without affecting normal hemostasis in mice. 2-Methoxybenzoic acid can be used for the research of arterial thrombosis .

HY-113507

PC(O-16:0/18:2(9Z,12Z))	Structural Classification Marine natural products Marine microorganism Lipid Source Classification	Phospholipase
PC(O-16:0/18:2(9Z,12Z)) is a phospholipid. PC(O-16:0/18:2(9Z,12Z)) serves as a substrate for Phospholipase A2 .

HY-N16849

Myristinin A YM 26567-1	Structural Classification Horsfieldia amygdalina (Wall. ex Hook. f. & Thomson) Warb. Coumarins Myristicaceae Phenylpropanoids Plants Source Classification	COX Prostaglandin Receptor Fungal
Myristinin A (YM 26567-1) is a trans-isomer flavan compound found in Horsfieldia amygdaline and Myristica cinnamomea. Myristinin A can selectively inhibit COX-2 activity with an IC₅₀ of 16.9 μg/mL. Myristinin A can reduce the production of prostaglandin E2 (PGE2) and inhibit phospholipase A2 (PLA2), thereby blocking the release of inflammatory mediators. Myristinin A can inhibit Candida albicans with an IC₅₀ of 8.8 μg/mL. Myristinin A can be used for the research of inflammation and infection, such as rheumatoid arthritis .

HY-N16865

Myristinin B/C	Structural Classification Horsfieldia amygdalina (Wall. ex Hook. f. & Thomson) Warb. Coumarins Myristicaceae Phenylpropanoids Plants Source Classification	COX Prostaglandin Receptor Fungal
Myristinin B/C is a mixture of Myristinin B and Myristinin C. Myristinin B/C is a flavan compound found in Horsfieldia amygdaline and Myristica cinnamomea. Myristinin B/C can selectively inhibit COX-2 activity with an IC₅₀ of 2.1 μg/mL. Myristinin B/C can reduce the production of prostaglandin E2 (PGE2) and inhibit phospholipase A2 (PLA2), thereby blocking the release of inflammatory mediators. Myristinin B/C can inhibit Candida albicans with an IC₅₀ of 6 μg/mL. Myristinin B/C can be used for the research of inflammation and infection, such as rheumatoid arthritis .

Cat. No.	Product Name	Chemical Structure

HY-W019838S

D-Erythro-dihydrosphingosine-d7
D-Erythro-dihydrosphingosine-d₇ is the deuterium labeled D-Erythro-dihydrosphingosine. D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.

HY-13402S

Varespladib-d7

Varespladib-d₇ (LY315920-d₇) is a deuterated labeled Varespladib (HY-13402). Varespladib is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC₅₀ of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC₅₀s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

HY-117068S

(R)-Bromoenol lactone-d7
(R)-Bromoenol lactone-d₇ ((R,E)-Bromoenol lactone-d₇) is deuterium labeled (R)-Bromoenol lactone. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of *calcium-independent phospholipase* γ (iPLA2γ). (R)-BEL inhibits human recombinant iPLA2γ with an IC₅₀** of approximately 0.6 μM .

HY-146925S

15:0 Lyso PC-d5

15:0 Lyso PC-d₅ is deuterium labeled 15:0 Lyso PC (HY-W329357). 15:0 Lyso PC is a lysophosphatidylcholine (Lyso PC), a product of phospholipase A2 (PLA2) hydrolysis of phosphatidylcholine (PC) and is involved in cell membrane remodeling and inflammatory signaling. 15:0 Lyso PC demonstrates significant lipid metabolism disturbances in the serum of patients with ischemic heart disease (IHD) and ischemic cardiomyopathy (ICM). 15:0 Lyso PC can be used as a lipid biomarker for cardiovascular disease.

HY-N1393S

2-Methoxybenzoic acid-13C6

2-Methoxybenzoic acid (NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether)- ¹³C₆ is the ¹³C-labeled 2-Methoxybenzoic acid (HY-N1393). 2-Methoxybenzoic acid is a natural compound with potential salicylate-like effect. 2-Methoxybenzoic acid inhibits carbonic anhydrase activity, elevates intraplatelet cyclic guanosine monophosphate level, and suppresses cytosolic phospholipase A₂ phosphorylation. 2-Methoxybenzoic acid suppresses platelet reactivity, including decreased spreading, retraction, and aggregation in platelets. 2-Methoxybenzoic acid ameliorates arterial thrombosis in a dose-dependent manner without affecting normal hemostasis in mice. 2-Methoxybenzoic acid can be used for the research of arterial thrombosis .

HY-N1393S1

2-Methoxybenzoic acid-d3

2-Methoxybenzoic acid (NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether)-d₃ is deuterium-labeled 2-Methoxybenzoic acid (HY-N1393). 2-Methoxybenzoic acid is a natural compound with potential salicylate-like effect. 2-Methoxybenzoic acid inhibits carbonic anhydrase activity, elevates intraplatelet cyclic guanosine monophosphate level, and suppresses cytosolic phospholipase A₂ phosphorylation. 2-Methoxybenzoic acid suppresses platelet reactivity, including decreased spreading, retraction, and aggregation in platelets. 2-Methoxybenzoic acid ameliorates arterial thrombosis in a dose-dependent manner without affecting normal hemostasis in mice. 2-Methoxybenzoic acid can be used for the research of arterial thrombosis .

Cat. No.	Product Name		Classification

HY-W800785

16:0-23:2 Diyne PC 1-palMitoyl-2-(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine		Phospholipids
16:0-23:2 Diyne PC is a phospholipase-mediated hydrolyzed phosphocoline with palmitic acid (16:0) and Pentacosa-10,12-diynoic acid for tails.

HY-W800784

23:2 Diyne PE [DC(8,9)PE]		Phospholipids
23:2 Diyne PE [DC(8,9)PE] is a phospholipase-mediated hydrolyzed phosphocoline with palmitic acid (16:0) and Pentacosa-10,12-diynoic acid for tails.

HY-157718

1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine		Phospholipids
1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine is a surfactant that has the activity of promoting liposome formation. 1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine can effectively study the biological effects of ceramide and ceramide phosphate. 1,2-Di-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine shows important application in the determination of phospholipase A activity of lecithin-cholesterol acyltransferase in ether matrix.

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