110683-10-8
Chemical Structure
(E/Z)-BML264
Synonym(s): N-(p-Amylcinnamoyl) anthranilic acid; ACA
- CAS. Nr.: 110683-10-8
- Formula:C21H23NO3
- Molecular Weight:337.41
IUPAC Name: (E)-2-(3-(4-pentylphenyl)acrylamido)benzoic acid
InChIKey: GAMRBCZMOOMBSQ-CCEZHUSRSA-N
SMILES: CCCCCC1=CC=C(C=C1)/C=C/C(NC2=CC=CC=C2C(O)=O)=O
Biological Activity: (E/Z)-BML264 (N-(p-amylcinnamoyl) Anthranilic Acid) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker[1][2]. (E/Z)-BML264 is a SLC13A3 inhibitor. (E/Z)-BML264 (N-(p-amylcinnamoyl) Anthranilic Acid) is also an effective reversible inhibitor of calcium-activated chloride channels, has potential to treat arrhythmia[3][4].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
(E/Z)-BML264 | 99.72% | (E/Z)-BML264 (N-(p-amylcinnamoyl) Anthranilic Acid) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker. (E/Z)-BML264 is a SLC13A3 inhibitor. (E/Z)-BML264 (N-(p-amylcinnamoyl) Anthranilic Acid) is also an effective reversible inhibitor of calcium-activated chloride channels, has potential to treat arrhythmia. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 1.00
HY-118628ABML264 -
Similarity Score 0.83
HY-123070ONO-RS-082 -
Similarity Score 0.78
HY-118693Avenanthramide D -
Similarity Score 0.69
HY-N17673Avenanthramide 1c -
Similarity Score 0.69
HY-126734Avenanthramide E -
Similarity Score 0.69
HY-181140UNPD139734 -
Similarity Score 0.68
HY-18706trans-Tranilast -
Similarity Score 0.68
HY-B0195Tranilast -
Similarity Score 0.66
HY-100495RFT011 (Standard) -
Explore the MedChemAI to find more analogs
References
- [1]. Kraft R, et al. Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol. 2006 Jun;148(3):264-73. [Content Brief]
- [2]. Harteneck C, et al. N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A(2) inhibitor and TRP channel blocker. Cardiovasc Drug Rev. 2007 Spring;25(1):61-75. [Content Brief]
- [3]. Gwanyanya A, et al. Inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by N-(p-amylcinnamoyl)anthranilic acid (ACA). Biochem Biophys Res Commun. 2010 Nov 19;402(3):531-6. [Content Brief]
- [4]. Fan Y, et al. Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1. Cell Metab. 2025 Feb 4;37(2):514-526.e5. [Content Brief]
