10147 Results for "

products

" in MedChemExpress (MCE) Product Catalog:
Products (10147)

10147 Results for "products" in MCE Product Catalog:

300
300 Publications Verification
Cat. No.: HY-10999A
CAS No.: 1187431-43-1
Purity:  99.56%
Synonyms: GSK-1120212 (DMSO solvate); JTP-74057 (DMSO solvate)
Target:  

MEK Apoptosis

Research Areas:  

Cancer

Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib (DMSO solvate) activates autophagy and induces apoptosis . This product is in solid form, a DMSO solvate, and a stable crystalline form.
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92
92 Cited Publications
Cat. No.: HY-N0322A
Cholesterol Water Soluble is a major sterol in mammals, constituting 20-25% of the structural composition of the plasma membrane. The plasma membrane is highly permeable to water but relatively impermeable to ions and protons. Cholesterol Water Soluble plays an important role in determining the fluidity and permeability characteristics of membranes and the function of transporters and signaling proteins. Cholesterol Water Soluble is also an endogenous estrogen-related receptor alpha (ERRα) agonist. Cholesterol Water Soluble can be used to study the effects of cholesterol on potassium currents in inner hair cells .
(Note: This product is a mixture of Cholesterol and Methyl-β-cyclodextrin. The product specifications below only indicate the effective content of Cholesterol.)
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66
66 Cited Publications
Cat. No.: HY-P9907
CAS No.: 180288-69-1
Synonyms: Anti-Human HER2, Humanized Antibody
Trastuzumab is a humanized IgG1 monoclonal antibody that selectively binds to HER2 with high affinity. Trastuzumab can be used for the research of HER2-positive metastatic breast cancer and gastric cancer . (Note: The product specifications below only indicate the effective content of Trastuzumab. The component ratio of this product is Trastuzumab : excipients = 1:0.6-1:0.9.)
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63
63 Cited Publications
Cat. No.: HY-B2227B
CAS No.: 72-17-3
Synonyms: DL-Lactic acid sodium; E-270 sodium
Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative .
This product has a content (w/w) of 60%, and 1 mL of the system contains 798 mg of Lactic acid sodium, i.e., a concentration of 798 mg/mL (i.e., 7.12 M).
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32
32 Cited Publications
Cat. No.: HY-F0004
CAS No.: 1094-61-7
Synonyms: β-Nicotinamide mononucleotide; β-NM; NMN
Fosribnicotinamide (β-nicotinamide mononucleotide) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD + intermediate. The pharmacological activities of Fosribnicotinamide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity .
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28
28 Cited Publications
Cat. No.: HY-N0593
CAS No.: 83-44-3
Synonyms: Cholanoic acid; Desoxycholic acid
Deoxycholic acid (cholanoic acid), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5 .
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28
28 Cited Publications
Cat. No.: HY-N0593A
CAS No.: 302-95-4
Synonyms: Sodium deoxycholate
Deoxycholic acid sodium salt (sodium deoxycholate), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5 .
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24
24 Cited Publications
Cat. No.: HY-K6002

MCE Basement Membrane Matrix is primarily composed of natural basement membrane matrix extracted from mouse tumors.This product is mainly used for studies of tumor invasion, angiogenesis and organoids culture while avoiding color interference in subsequent experiments.

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21
21 Cited Publications
Cat. No.: HY-K6001

MCE Basement Membrane Matrix (Phenol Red) is primarily composed of a natural basement membrane matrix derived from mouse tumors. This product is mainly for studies of tumor invasion, angiogenesis, and organoid culture.

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21
21 Cited Publications
Cat. No.: HY-129905
CAS No.: 6491-83-4
Purity:  98.92%
Synonyms: LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress .
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21
21 Cited Publications
Cat. No.: HY-129905A
CAS No.: 16689-14-8
Purity:  99.69%
Synonyms: LLOMe hydrobromide; Leu-Leu methyl ester hydrobromide; H-Leu-Leu-OMe hydrobromide
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrobromide also can induce endolysosomal pathway stress .
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19
19 Cited Publications
Cat. No.: HY-N0287
CAS No.: 502-65-8
Lycopene is naturally occurring carotenoids found in tomato, tomato products, and in other red fruits and vegetables; exhibits antioxidant effects.
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17
17 Cited Publications
Cat. No.: HY-N0697
CAS No.: 42553-65-1
Synonyms: Crocin I
Crocin (Crocin I) is an orally active natural product that can be isolated from the stigma of Crocus sativus. Crocin inhibits tumor cell proliferation and promotes apoptosis through JAK pathway. Crocin has anti-inflammatory, antioxidant and antitumor activities .
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17
17 Cited Publications
Cat. No.: HY-50682
CAS No.: 603148-36-3
Synonyms: TTP488; PF-04494700
Target:  

Amyloid-β

Research Areas:  

Neurological Disease Cancer

Azeliragon (TTP488) is an orally bioavailable inhibitor of the receptor for advanced glycation end products (RAGE) in development as a potential treatment to slow disease progression with mild Alzheimer’s disease (AD) . Azeliragon also can cross the blood-brain barrier (BBB) .
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15
15 Cited Publications
Cat. No.: HY-N0567
CAS No.: 78281-02-4
Synonyms: Safflomin A; HSYA
Hydroxysafflor yellow A (Safflomin A) is a natural product of flavonoids isolated from safflower. Hydroxysafflor yellow A can inhibit cell proliferation and promote apoptosis through the autophagy pathway. Hydroxysafflor yellow A has anti-inflammatory, antioxidant and antitumor effects. Hydroxysafflor yellow A can be used in the study of cardiovascular disease .
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14
14 Cited Publications
Cat. No.: HY-N6972
CAS No.: 481-49-2
Cepharanthine is a natural product that can be isolated from the plant Stephania cephalantha Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activities. Cepharanthine has good effective in suppressing viral proliferation (half maximal (50%) inhibitory concentration (IC50) and 90% inhibitory concentration (IC90) values of 1.90 and 4.46 μM . Cepharanthine can also effectively reverses P-gp-mediated multidrug resistance in K562 cells and increase enhances the sensitivity of anticancer agents in xenograft mice model . Cepharanthine shows inhibitory effects of human liver cytochrome P450 enzymes CYP3A4, CYP2E1 and CYP2C9. Cepharanthine has antitumor, anti-inflammatory and antinociceptive effects .
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14
14 Cited Publications
Cat. No.: HY-B1610
CAS No.: 6132-04-3
Synonyms: Trisodium citrate dihydrate; Citric acid trisodium salt dihydrate
Sodium citrate (Trisodium citrate) dihydrate is an orally active natural product that can be found in citrus fruits. Sodium citrate dehydrate can inhibit the proliferation of tumor cells and induce apoptosis. Sodium citrate dehydrate has antibacterial, anti-tumor and antioxidant activities. Sodium citrate dehydrate can be prepared as a cosolvent or buffer .
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13
13 Cited Publications
Cat. No.: HY-B1610I
CAS No.: 6132-04-3
Synonyms: Trisodium citrate dihydrate, for molecular biology
Sodium citrate (Trisodium citrate) dihydrate, for molecular biology is an orally active natural product that can be found in citrus fruits. Sodium citrate dihydrate can inhibit the proliferation of tumor cells and induce apoptosis. Sodium citrate dihydrate has antibacterial, anti-tumor and antioxidant activities. Sodium citrate dihydrate can be prepared as a cosolvent or buffer .
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12
12 Cited Publications
Cat. No.: HY-K0302

MCE Cell-ATP Viability Detection Kit is used for detecting the number and viability of living cells in culture based on high-sensitivity bioluminescence detection technology of the ATP present.Product specifications: Large sizes are based on 100 mL increments.

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11
11 Cited Publications
Cat. No.: HY-N0033
CAS No.: 94079-81-9
Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC50s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity .
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