3 Results for "

rat ileum smooth muscle

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "rat ileum smooth muscle" in MCE Product Catalog:

Arcapillin
Arcapillin
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Cat. No.: HY-121020
CAS No.: 83162-82-7
Category:  

Flavonoids Flavones Plants Compositae Artemisia capillaris Thunb.

Target:  

SARS-CoV

Arcapillin is a flavonoid that can be isolated from Artemisia capillaris Thunb. Arcapillin induces dose-dependent relaxation of ileum and pulmonary artery smooth muscle, causes slight urinary bladder smooth muscle contraction at highest tested concentrations. Arcapillin binds to the active site of SARS-CoV-2 Mpro via interactions with Gln139, His163, and His164, exhibits antiviral activity against SARS-CoV-2 and MERS-CoV. Arcapillin can be used for the research of gastrointestinal disorders, COVID-19, and Middle East respiratory syndrome (MERS) .
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Barakol
Barakol
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Cat. No.: HY-167825
CAS No.: 24506-68-1
Category:  

Seeds of Cassia tora Linn. Natural Products Leguminosae Plants

Target:  

MMP Apoptosis Bcl-2 Family Reactive Oxygen Species (ROS)

Barakol is an anticancer and anxiolytic agent identified in Cassia siamea. Barakol inhibits MMP-3 activity and enhances the cytotoxicity and antimetastatic effects of Doxorubicin (HY-15142) against cancer cells. Barakol induces apoptosis via reactive oxygen species (ROS) production, upregulation of the Bax/Bcl-2 protein ratio, and activation of caspase-9. Barakol exerts anxiolytic activity with diazepam-like effects, increases spontaneous longitudinal smooth muscle contraction of rat ileum in a concentration-dependent manner (EC50 = 0.3 mM), and inhibits norepinephrine-induced contraction suppression. Barakol can be used in research related to anxiety, intestinal motility, and neuroblastoma .
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[Trp11]-Neurotensin
[Trp11]-Neurotensin
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Cat. No.: HY-P3057A
CAS No.: 75644-95-0
Target:  

Neurotensin Receptor

Research Areas:  

Neurological Disease

[Trp11]-Neurotensin is a neurotensin analog and neurotensin receptor agonist. The Tyr11 residue of neurotensin is replaced by L-Trp. [Trp11]-Neurotensin competes for neurotensin receptor binding sites, with an IC50 of 4.3 nM in rat brain synaptic membranes, and activates neurotensin receptor-mediated smooth muscle responses, with an EC50 of 1.7 nM in rat ileum, exhibiting significant species-dependent differences in receptor recognition. [Trp11]-Neurotensin can be used in studies related to neurotensin receptor pharmacology, gastrointestinal smooth muscle, and species-dependent receptor recognition .
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