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rodent carcinogen

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (2) c-Myc (2) Cytochrome P450 (1) Environmental Pollutants (2) Fluorescent Dye (1) Herbicide (1) Reference Standards (2)
By Research Areas:	Cancer (4)

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Fluorescent Dyes

Natural
Products

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-W011845

DMBA 3 Publications Verification 7,12-DMBA; 7,12-Dimethylbenzanthracene	Environmental Pollutants c-Myc	Cancer
DMBA has *carcinogenic* activity as a polycyclic aromatic hydrocarbon (PAH). DMBA is used to induce tumor formation in various rodent models .

HY-139838

Epyrifenacil	Herbicide	Others Cancer
Epyrifenacil is a protoporphyrinogen oxidase (PPO) inhibiting herbicide, potently targeting the PPO₂isoform from weeds such as Amaranthus palmeri with an IC₅₀ of 0.637 nM. Epyrifenacil also inhibits liver mitochondrial PPO across species, with IC₅₀ values of 2.2 nM (mouse), 2.6 nM (rat), 12.1 nM (rabbit), 7.6 nM (dog), and 10.2 nM (human). Epyrifenacil induces liver tumor development in mice. Epyrifenacil can be used for weed control, and also used as a tool compound in toxicological research to study the mechanism of PPO inhibition, chemical-induced hepatotoxicity, and the mode of action of non-genotoxic carcinogens in rodents ^[3].

HY-W030778

Nitrilotriacetic acid 1 Publications Verification Triglycollamic acid	Biochemical Assay Reagents	Others
Nitrilotriacetic acid is an orally active chelating agent for metal ions. Nitrilotriacetic acid is an aminotricarboxylic acid that can sequester metal ions as water soluble complexes. Nitrilotriacetic acid reacts with strong oxidizing agents such as hypochlorite, chlorine, ozone, or oxygen in the presence of palladium/carbon catalyst. Nitrilotriacetic acid interacts with solid phases such as cell membranes and bone matrices in the mammalian system. Nitrilotriacetic acid is classified as an epigenetic rodent carcinogen .

HY-W271064

1-Methylpyrene	Environmental Pollutants Fluorescent Dye	Others
1-Methylpyrene is a ubiquitous environmental pollutant and rodent carcinogen. Its mutagenic activity depends on sequential activation by various CYP and sulfotransferase (SULT) enzymes. 1-Methylpyrene induces chromosome loss and mitotic disturbance, proba

HY-W011845R

DMBA (Standard) 7,12-DMBA (Standard); 7,12-Dimethylbenzanthracene (Standard)	c-Myc Reference Standards	Cancer
DMBA has carcinogenic activity as a polycyclic aromatic hydrocarbon (PAH). DMBA is used to induce tumor formation in various rodent models .

HY-W030778R

Nitrilotriacetic acid (Standard) Triglycollamic acid (Standard)	Biochemical Assay Reagents Reference Standards	Others
Nitrilotriacetic acid (Standard) is the analytical standard of Nitrilotriacetic acid. This product is intended for research and analytical applications. Nitrilotriacetic acid is an orally active chelating agent for metal ions. Nitrilotriacetic acid is an aminotricarboxylic acid that can sequester metal ions as water soluble complexes. Nitrilotriacetic acid reacts with strong oxidizing agents such as hypochlorite, chlorine, ozone, or oxygen in the presence of palladium/carbon catalyst. Nitrilotriacetic acid interacts with solid phases such as cell membranes and bone matrices in the mammalian system. Nitrilotriacetic acid is classified as an epigenetic rodent carcinogen .

HY-N1500A

(S)-Pulegone (-)-Pulegone	Cytochrome P450	Cancer
(S)-Pulegone ((-)-Pulegone) is a cytochrome P450 (CYP450) substrate. (S)-Pulegone induces urothelial cytotoxicity, necrosis, regenerative proliferation and urinary bladder tumors in female rats. (S)-Pulegone induces rodent nephropathy, olfactory metaplasia, gastric hyperplasia/perforation at high dose. (S)-Pulegone can be used for the research of urinary bladder and hepatic neoplasms .

1-Methylpyrene	Fluorescent Dyes
1-Methylpyrene is a ubiquitous environmental pollutant and rodent carcinogen. Its mutagenic activity depends on sequential activation by various CYP and sulfotransferase (SULT) enzymes. 1-Methylpyrene induces chromosome loss and mitotic disturbance, proba

Cat. No.	상품명	Category	Target	Chemical Structure

HY-N1500A

(S)-Pulegone (-)-Pulegone	Structural Classification Natural Products Glycyrrhiza aspera Pall. Labiatae Plants Source Classification	Cytochrome P450
(S)-Pulegone ((-)-Pulegone) is a cytochrome P450 (CYP450) substrate. (S)-Pulegone induces urothelial cytotoxicity, necrosis, regenerative proliferation and urinary bladder tumors in female rats. (S)-Pulegone induces rodent nephropathy, olfactory metaplasia, gastric hyperplasia/perforation at high dose. (S)-Pulegone can be used for the research of urinary bladder and hepatic neoplasms .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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rodent carcinogen

Inhibitors & Agonists

Fluorescent Dyes

NaturalProducts

Natural
Products