2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. (S)-Pulegone

(S)-Pulegone ((-)-Pulegone) is a cytochrome P450 (CYP450) substrate. (S)-Pulegone induces urothelial cytotoxicity, necrosis, regenerative proliferation and urinary bladder tumors in female rats. (S)-Pulegone induces rodent nephropathy, olfactory metaplasia, gastric hyperplasia/perforation at high dose. (S)-Pulegone can be used for the research of urinary bladder and hepatic neoplasms.

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(S)-Pulegone

(S)-Pulegone Chemical Structure

CAS No. : 3391-90-0

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Other Forms of (S)-Pulegone:

(S)-Pulegone Related Antibodies

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View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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Description

(S)-Pulegone ((-)-Pulegone) is a cytochrome P450 (CYP450) substrate. (S)-Pulegone induces urothelial cytotoxicity, necrosis, regenerative proliferation and urinary bladder tumors in female rats. (S)-Pulegone induces rodent nephropathy, olfactory metaplasia, gastric hyperplasia/perforation at high dose. (S)-Pulegone can be used for the research of urinary bladder and hepatic neoplasms[1].

Cellular Effect
Cell Line Type Value Description References
CAKI-1 LC50
359 μM
Compound: 13
Lethal concentration required to kill 50% C33A cells of the human cervical cells with a mutation at Cys 273
Lethal concentration required to kill 50% C33A cells of the human cervical cells with a mutation at Cys 273
[PMID: 15482940]
Molecular Weight

152.24

Formula

C10H16O
CAS No.
SMILES

C(C)(C)=C1C(=O)C[C@@H](C)CC1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(S)-Pulegone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-Pulegone3391-90-0(-)-PulegoneCytochrome P450CYPsfemale ratshepatic carcinogenicityurothelial cytotoxicityhepatotoxicitycytochrome P450miceurinary bladder tumorsmenthofuranrodent gastrointestinal tractCYP450Inhibitorinhibitorinhibit

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