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Results for "

selective anticancer activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	17β-HSD (1) 5-HT Receptor (5) Ack1 (1) ADC Payload (1) Adrenergic Receptor (1) Akt (10) Aldehyde Dehydrogenase (ALDH) (3) Aldose Reductase (1) AMPK (3) Anaplastic lymphoma kinase (ALK) (5) Androgen Receptor (4) Angiotensin Receptor (3) Antibiotic (5) Antifolate (1) AP-1 (1) Apoptosis (113) Arenavirus (1) Arf Family GTPase (1) Arrestin (1) Aryl Hydrocarbon Receptor (3) Asialoglycoprotein Receptor (ASGPR) (1) Atg7 (1) Atg8/LC3 (2) ATM/ATR (3) ATP Synthase (1) ATP-binding cassette (ABC) transporters (1) Aurora Kinase (2) AUTACs (1) Autophagy (35) Bacterial (14) Bcl-2 Family (10) BCL6 (1) Bcr-Abl (1) BCRP (1) Biochemical Assay Reagents (1) BTB/POZ Family (1) Btk (1) c-Fms (2) c-Kit (3) c-Met/HGFR (5) c-Myc (7) Calcium Channel (1) CaMK (1) Carbamoyl Phosphate Synthetase (CPS) (1) Carbonic Anhydrase (1) Casein Kinase (1) Caspase (13) CDK (25) Checkpoint Kinase (Chk) (5) CHIKV (1) Chloride Channel (1) Cholinesterase (ChE) (3) COX (13) CXCR (2) Cytochrome P450 (10) Dengue Virus (1) Deubiquitinase (3) Dihydroorotate Dehydrogenase (1) Discoidin Domain Receptor (2) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (12) Drug Derivative (4) Drug Intermediate (2) Drug Metabolite (2) DYRK (1) E1/E2/E3 Enzyme (1) EBV (1) EGFR (13) Endogenous Metabolite (2) Endonuclease (1) Enterovirus (1) Environmental Pollutants (1) Epigenetic Reader Domain (13) ERK (4) Estrogen Receptor/ERR (4) FAK (3) Farnesyl Transferase (2) Ferroptosis (10) FGFR (3) FKBP (4) Flavivirus (1) FLT3 (1) Fluorescent Dye (1) Free Fatty Acid Receptor (1) Fungal (8) G-quadruplex (1) Glucocorticoid Receptor (1) GLUT (1) Glutathione Peroxidase (3) Glutathione S-transferase (1) GSK-3 (3) Haspin Kinase (2) HBV (4) HDAC (14) Hedgehog (2) HIF/HIF Prolyl-Hydroxylase (3) Histone Acetyltransferase (4) Histone Demethylase (4) Histone Methyltransferase (9) HIV (7) HIV Protease (4) HSP (4) HyT (2) IAP (2) IFNAR (2) IGF-1R (6) IKK (3) IMPDH (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Insulin Receptor (4) Interleukin Related (6) IRAK (1) IRE1 (1) Isocitrate Dehydrogenase (IDH) (2) Isotope-Labeled Compounds (4) JAK (5) JNK (2) Kinesin (1) Lactate Dehydrogenase (1) Lipoxygenase (1) MAP4K (2) MDM-2/p53 (6) MEK (2) Melanocortin Receptor (1) Methylenetetrahydrofolate Dehydrogenase (MTHFD) (1) Microtubule/Tubulin (3) Mitochondrial Metabolism (5) Mitosis (2) MMP (9) Mps1 (3) mTOR (9) Na+/K+ ATPase (2) nAChR (1) Necroptosis (3) NF-κB (7) NO Synthase (2) Organoid (5) Oxidative Phosphorylation (1) P-glycoprotein (2) p38 MAPK (9) PAK (1) Parasite (4) PARP (7) PDGFR (1) PDHK (1) PERK (2) Phosphatase (2) Phosphodiesterase (PDE) (1) PI3K (6) Pim (2) PKC (2) Polo-like Kinase (PLK) (7) Potassium Channel (2) Pregnane X Receptor (PXR) (1) Prolyl Endopeptidase (PREP) (2) Prostaglandin Receptor (2) PROTACs (21) Pyroptosis (1) Pyruvate Kinase (1) Quinone Reductase (1) Raf (1) Ras (5) Reactive Oxygen Species (ROS) (20) Reference Standards (37) RET (3) Reverse Transcriptase (2) Ribosomal S6 Kinase (RSK) (2) RIO Kinase (1) ROCK (1) ROS Kinase (4) Salt-inducible Kinase (SIK) (1) SARS-CoV (4) Sigma Receptor (3) Sirtuin (4) SNIPERs (1) SOS1 (1) Src (5) STAT (8) STING (1) Survivin (1) SWI/SNF Complex (2) Telomerase (2) TGF-beta/Smad (2) Tie (2) TNF Receptor (2) Toll-like Receptor (TLR) (4) TOPK (1) Topoisomerase (3) Trk Receptor (1) TRP Channel (1) TrxR (1) VDAC (1) VEGFR (6) Wee1 (1) Wnt (1) YAP (2) γ-secretase (2)
By Research Areas:	Cancer (367) Cardiovascular Disease (9) Endocrinology (7) Infection (30) Inflammation/Immunology (52) Metabolic Disease (13) Neurological Disease (32)
Click Chemistry:	PROTAC Synthesis (1)

377

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

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Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114370

Selpercatinib 10+ Cited Publications LOXO-292	RET	Cancer
Selpercatinib (LOXO-292) is a potent, selective RET kinase inhibitor with IC₅₀ values of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively. Selpercatinib has anticancer activity .

HY-N0018

Daidzin 10+ Cited Publications Daidzoside; NPI-031D; Daidzein 7-O-glucoside	Mitochondrial Metabolism Reverse Transcriptase Aldehyde Dehydrogenase (ALDH)	Cardiovascular Disease Others Cancer
Daidzin is an isoflavone with antioxidant, anticancer, and antiatherosclerotic activities. Daidzin is a potent and selective inhibitor of mitochondrial ALDH-2. Daidzin reduces ethanol consumption .

HY-100003

ML-210 25+ Cited Publications	Glutathione Peroxidase Ferroptosis	Cancer
ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC₅₀ of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity .

HY-114429

CB-6644 10+ Cited Publications	DNA/RNA Synthesis	Cancer
CB-6644 is a selective inhibitor of RUVBL1/2 complex with anti-cancer activity. CB-6644 blocks the ATPase activity of RUVBL1/2 with an IC₅₀ of 15 nM .

HY-14645

(-)-DHMEQ 30+ Cited Publications Dehydroxymethylepoxyquinomicin	NF-κB	Inflammation/Immunology Cancer
(-)-DHMEQ (Dehydroxymethylepoxyquinomicin) is a potent, selective and irreversible NF-κB inhibitor that covalently binds to a cysteine residue. (-)-DHMEQ inhibits nuclear translocation of NF-κB and shows anti-inflammatory and anticancer activity .

HY-N0069

Solamargine 10+ Cited Publications Solamargin; δ-Solanigrine	P-glycoprotein Apoptosis	Cancer
Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity .

HY-N0038

Alantolactone 5+ Cited Publications (+)-Alantolactone; Alant camphor; Inula camphor	STAT Apoptosis TGF-beta/Smad	Cancer
Alantolactone is a selective STAT3 inhibitor, with potent anticancer activity. Alantolactone induces apoptosis in cancer .

HY-N1405

Cucurbitacin I Maximum Cited Publications 13 Publications Verification Elatericin B; JSI-124; NSC-521777	STAT JAK	Cancer
Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity.

HY-101340

Luvixasertib 5+ Cited Publications CFI-402257	Mps1	Cancer
CFI-402257 is a highly selective and orally bioavailable TTK/Mps1 inhibitor with an IC₅₀ of 1.7 nM for TTK in vitro. CFI-402257 has anti-cancer activity .

HY-100888

Simurosertib 10+ Cited Publications TAK-931	CDK	Cancer
Simurosertib (TAK-931) is an orally active, selective and ATP-competitive cell division cycle 7 (CDC7) kinase inhibitor, with an IC₅₀ of <0.3 nM. Simurosertib has anti-cancer activity .

HY-116213

Sparstolonin B 5+ Cited Publications	Toll-like Receptor (TLR) HIV	Infection Inflammation/Immunology Cancer
Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities .

HY-162431

Calderasib MK-1084	Ras	Cancer
Calderasib (MK-1084) is a selective KRAS G12C inhibitor. Calderasib exhibits anticancer activity and can be used either alone or in combination with Pembrolizumab (HY-P9902) for cancer research .

HY-134217

KYN-101	Aryl Hydrocarbon Receptor	Cancer
KYN-101 is a potent, selective and orally active AHR inhibitor. KYN-101 decreases the CYP1A1 mRNA expression. KYN-101 shows anti-cancer activity .

HY-12406

VLX600 2 Publications Verification	Oxidative Phosphorylation Mitochondrial Metabolism Autophagy	Cancer
VLX600 is an iron-chelating inhibitor of oxidative phosphorylation (OXPHOS). VLX600 causes mitochondrial dysfunction and induces a strong shift to glycolysis. VLX600 displays selective cytotoxic activity against malignant cell and induces autophagy. Anticancer activity .

HY-133618

Pomalidomide-C3-adavosertib	Wee1 PROTACs	Cancer
Pomalidomide-C3-adavosertib is a rapid and selective PROTAC Wee1 degrader (IC₅₀=3.58 nM). Pomalidomide-C3-adavosertib shows anti-cancer cell proliferation activity, and induces apoptosis .

HY-120856

ARN-3236 4 Publications Verification	Salt-inducible Kinase (SIK)	Inflammation/Immunology Cancer
ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), with IC₅₀s of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. Has anti-cancer activity .

HY-138280

DTHIB 5+ Cited Publications	HSP	Cancer
DTHIB is a direct and selective heat shock factor 1 (HSF1) inhibitor with a K_d of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB inhibits HSF1 cancer gene signature (HSF1 CaSig) and selectively stimulates degradation of nuclear HSF1. DTHIB has potently anticancer activities and can be used for prostate cancer research .

HY-18973

Dp44mT 5 Publications Verification	Apoptosis Ferroptosis	Cancer
Dp44mT is an iron chelator with selective anticancer activity.

HY-100556

Tie2 kinase inhibitor 1 1 Publications Verification	Tie	Cancer
Tie2 kinase inhibitor 1 (compound 5) is a potent, selective Tie2 kinase inhibitor with an IC₅₀ of 250 nM . Tie2 kinase inhibitor 1 has anti-cancer activity .

HY-N10457

Norstictic acid	Bacterial	Infection Cancer
Norstictic acid is a potent and selective allossteric transcriptional regulator. Norstictic acid shows anticancer activity. Norstictic acid shows antioxidant activity and antimicrobial activity .

HY-17601

Alofanib 4 Publications Verification RPT835	FGFR Apoptosis	Cardiovascular Disease Cancer
Alofanib (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2). Anticancer and antiangiogenic activity .

HY-125974

HM03 4 Publications Verification	HSP	Cancer
HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity .

HY-101340A

Luvixasertib hydrochloride 5+ Cited Publications CFI-402257 hydrochloride	Mps1	Cancer
CFI-402257 hydrochloride is a highly selective and orally bioavailable TTK/Mps1 inhibitor with an IC₅₀ of 1.7 nM for TTK in vitro. CFI-402257 hydrochloride has anti-cancer activity .

HY-N0929

Hexahydrocurcumin	COX Reactive Oxygen Species (ROS)	Cancer
Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-128577

NIC3 1 Publications Verification	BTB/POZ Family	Cancer
NIC3 is a selective nucleus accumbens-associated protein-1 (NAC1) inhibitor, binds to the conserved Leu-90 of NAC1, prevents its homodimerization, and leads to proteasomal NAC1 degradation. Anti-cancer activity .

HY-41404

Piperonylic acid 2H-1,3-benzodioxole-5-carboxylic acid	Cytochrome P450 Interleukin Related EGFR IGF-1R	Infection Others Cancer
Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase. Piperonylic acid has anticancer, antioxidant and antibacterial activities .

HY-123242

FTI-2153	Farnesyl Transferase	Cancer
FTI-2153 is a potent and highly selective inhibitor of farnesyltransferase (FTase), with an IC₅₀ of 1.4 nM. FTI-2153 is >3000-fold more potent at blocking H-Ras (IC₅₀, 10 nM) than Rap1A processing. Anti-cancer activity .

HY-P1102

TC14012 4 Publications Verification	CXCR HIV	Infection Cancer
TC14012, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC₅₀ of 19.3 nM. TC14012 is a potent CXCR7 agonist with an EC₅₀ of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has *anti-HIV* activity and anti-cancer activity .

HY-128784

PK11007	MDM-2/p53 Reactive Oxygen Species (ROS)	Cancer
PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels .

HY-139626

EPZ-719 4 Publications Verification	Histone Methyltransferase	Cancer
EPZ-719 is a selective, orally effective SETD2 inhibitor with an IC₅₀ value of 0.005 μM. EPZ-719 has anticancer activity .

HY-125166

DB04760 1 Publications Verification	MMP	Neurological Disease Cancer
DB04760 (compound 4) is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with an IC₅₀ of 8 nM . DB04760 significantly reduces paclitaxel neurotoxicity and has anticancer activity .

HY-18366A

RU-SKI 43 hydrochloride 2 Publications Verification	Hedgehog	Cancer
RU-SKI 43 hydrochloride is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC₅₀ of 850 nM. RU-SKI 43 hydrochloride reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 hydrochloride has anti-cancer activity .

HY-124740

ML00253764	Melanocortin Receptor	Cancer
ML00253764 is a selective melanocortin receptor 4 (MC4R) antagonist, can induce apoptosis by inhibiting ERK1/2 and Akt phosphorylation, and has anticancer activity .

HY-W010365

Rhodanine	Biochemical Assay Reagents Enterovirus Drug Intermediate	Infection Cancer
Rhodanine is a selective Echovirus 12 proliferation inhibitor and intermediate. Rhodanine is used to determine tannase activity. Rhodanine can be used in the synthesis of anticancer and antibacterial agents .

HY-19530

PF-2771	Kinesin	Cancer
PF-2771 is a potent and selective centromere protein E (CENP-E) inhibitor, inhibiting CENP-E motor activity with an IC₅₀ of 16.1 nM; PF-2771 is used as an anticancer agent.

HY-156174

E104	Toll-like Receptor (TLR) ADC Payload	Cancer
E104 (compound 1) is a potent and selective TLR7 agonist. E104 can be delivered by antibody-drug conjugate (ADC) technology to elicit potent anticancer activity. E104 induces the activation of mouse macrophages and hPBMCs .

HY-121093

DC-S239	Histone Methyltransferase	Cancer
DC-S239 is a selective histone methyltransferase SET7 inhibitor with an IC₅₀ value of 4.59 μM. DC-S239 also displays selectivity for DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a. DC-S239 has anticancer activity .

HY-152241

DS-9300	Histone Acetyltransferase	Cancer
DS-9300 is a potent, orally active, selective EP300/CBP HAT inhibitor with an IC₅₀ value of 28 nM. DS-9300 has anticancer activity and can be used in prostate cancer disease research .

HY-155582

BLK degrader 1	Src	Cancer
BLK degrader 1 (compound 9) is a selective degrader of B-lymphoid tyrosine kinase (BLK). BLK degrader 1 shows anticancer activity in several B-lymphoid cell lines .

HY-133511

MLS000544460	Phosphatase	Cancer
MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a K_d of 2.0 μM and an IC₅₀ of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity .

HY-N0018R

Daidzin (Standard) Daidzoside (Standard); NPI-031D (Standard); Daidzein 7-O-glucoside (Standard)	Reference Standards Mitochondrial Metabolism Reverse Transcriptase Aldehyde Dehydrogenase (ALDH)	Others
Daidzin (Standard) is the analytical standard of Daidzin. This product is intended for research and analytical applications. Daidzin is an isoflavone with antioxidant, anticancer, and antiatherosclerotic activities. Daidzin is a potent and selective inhibitor of mitochondrial ALDH-2. Daidzin reduces ethanol consumption .

HY-122661

Mefuparib hydrochloride MPH	PARP Apoptosis	Cancer
Mefuparib hydrochloride (MPH) is an orally active, substrate-competitive and selective PARP1/2 inhibitor with IC₅₀s of 3.2 nM and 1.9 nM, respectively. Mefuparib hydrochloride induces apoptosis and possesses prominent anticancer activity in vitro and in vivo .

HY-112927

MU380	Checkpoint Kinase (Chk)	Cancer
MU380 is a potent and selective CHK1 inhibitor that induces apoptosis and has anticancer activity .

HY-163858

Haspin-IN-4	Haspin Kinase	Cancer
Haspin-IN-4 (Compound 60) is a selective inhibitor of Haspin with an IC₅₀ value of 0.01 nM. Haspin-IN-4 possesses anticancer activity and can be used in cancer research .

HY-152236

PRMT6-IN-3	Histone Methyltransferase Apoptosis	Cancer
PRMT6-IN-3 (compound 25) is a selective PRMT6 inhibitor with an IC₅₀ value of 192 nM. PRMT6-IN-3 can induce apoptosis in cancer cells and has anticancer activity .

HY-18366

RU-SKI 43	Hedgehog	Cancer
RU-SKI 43 is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC₅₀ of 850 nM. RU-SKI 43 reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 has anti-cancer activity .

HY-N11785

Glyceollin I	Estrogen Receptor/ERR	Metabolic Disease Cancer
Glyceollin I is a selective estrogen receptor (ER) modulator with anticancer, antioxidant, and anti-inflammatory activities. Glyceollin I is promising for research of estrogen-related cancers (e.g., breast, ovarian) and metabolic disorders (e.g., hypercholesterolemia) .

HY-109174

Fosciclopirox CPX-POM	γ-secretase	Metabolic Disease Cancer
Fosciclopirox (CPX-POM) suppresses growth of urothelial cancer by targeting the γ-secretase complex. Fosciclopirox selectively delivers the active metabolite, Ciclopirox (CPX), to the entire urinary tract. Ciclopirox has anticancer activity in a number of solid and hematologic malignancies .

HY-147971

Anticancer agent 75	Parasite Topoisomerase	Infection Cancer
Anticancer agent 75 is a potent anticancer agent. Anticancer agent 75 shows cytotoxicity and selectivity in cancer cell lines. Anticancer agent 75 shows cytotoxicity to normal human kidney cell lines is at least 35 times lower than that of the Doxorubicin standard. Anticancer agent 75 shows good activity of antiplasmodial .

HY-137457A

Venadaparib hydrochloride IDX-1197 hydrochloride	PARP	Cancer
Venadaparib (IDX-1197) hydrochloride is a potent and selective PARP inhibitor with anticancer activities. Venadaparib hydrochloride can be used for solid tumors research .

Cat. No.	Product Name

HY-L167

Boronic Acid Compound Library

163 compounds

Boric acid is a stable and usually non-toxic group widely used in modern synthesis to form C-C and C-heteroatom bonds. Boric acid exhibits exquisite reversible coordination characteristics and can be explored as a molecular construction tool, with specific mechanisms for controlling the structure and biological characteristics of bioconjugates. Boric acid has various activities, such as anticancer, antibacterial, and antiviral activities. In drugs, boric acid mainly exists in the form of arylboronic acid. In addition to this form, heterocycles containing boric acid, such as pyridine, pyrrole, and indole derivatives, are also very useful in pharmaceutical chemistry. Molecular modification by introducing boric acid groups into bioactive molecules has been shown to alter selectivity, physicochemical, and pharmacokinetic characteristics, and improve existing activity.

MCE designs a unique collection of 163 boronic acid compounds. It is a good tool to be used for research on cancer and other diseases.

Cat. No.	Product Name	Target	Research Area

HY-P5712

Gramicidin S 1 Publications Verification Gramicidin soviet	Antibiotic Bacterial Na+/K+ ATPase	Infection
Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC₅₀s of 41 μM, 24 μM, and 3 μM for Na ⁺/K ⁺-ATPase, tobacco leaf plasma membrane Mg ²⁺/K ⁺-ATPase, and rat heart plasma membrane Ca ²⁺-ATPase, respectively .

HY-P1102

TC14012 4 Publications Verification	CXCR HIV	Infection Cancer
TC14012, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC₅₀ of 19.3 nM. TC14012 is a potent CXCR7 agonist with an EC₅₀ of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has *anti-HIV* activity and anti-cancer activity .

HY-P4809

Polybia-MP1	Bacterial Fungal	Infection Cancer
Polybia-MP1 is an antimicrobial peptide with antibacterial, antifungal and anticancer activities. Polybia-MP1 selectively targets cancer cells by interacting with PS and PE in the outer leaflet of cell membranes, and induces necrosis via pore formation. Polybia-MP1 exhibits antibacterial activity against Pseudomonas aeruginosa. Polybia-MP1 can be used in research related to bacterial infections, fungal infections and cancers .

HY-P1102A

TC14012 TFA	CXCR HIV	Infection Cancer
TC14012 TFA, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC₅₀ of 19.3 nM. TC14012 TFA is a potent CXCR7 agonist with an EC₅₀ of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 TFA has *anti-HIV* activity and anti-cancer activity .

HY-P10711

ALA-A2 peptide	Autophagy	Cancer
ALA-A2 is an anticancer peptide discovered in alpha-lactalbumin that selectively kills cancer cells by inducing Autophagy. ALA-A2 has cell-penetrating capabilities, allowing it to effectively enter cells without relying on membranolytic effects. In A549 lung cancer cells, ALA-A2 demonstrates significant dose-dependent anticancer activity. ALA-A2 holds promise for research in cancer therapy and autophagy regulation .

HY-P10669

NDI-Lyso	Caspase Apoptosis	Cancer
NDI-Lyso is a lysosome-targeted anticancer agent that induces the formation of rigid long fibers in cancer cell lysosomes through an enzyme-instructed self-assembly (EISA) mechanism catalyzed by cathepsin B. This process triggers lysosomal swelling, membrane permeabilization (LMP), and membrane disruption, ultimately leading to cancer cell apoptosis via a non-classical caspase-independent pathway. NDI-Lyso exhibits significant selective anticancer activity in various cancer cell lines and drug-resistant cancer cells (IC₅₀ ~10 μM) while showing low toxicity to normal cells (IC₅₀ > 60 μM) .

HY-P11298

d-T101 peptide	Caspase Apoptosis JNK p38 MAPK Interleukin Related IFNAR	Inflammation/Immunology Cancer
d-T101 peptide, a human hormone-peptide, is a T1/ST2 receptor ligand. d-T101 peptide binds to the T1/ST2 receptor and activates caspases 8, 9 and 3 mediated apoptosis, together with activation of JNKinase and p38 MAPKinase. d-T101 peptide also changes Golgi structural with function loss and downregulation of the endoplasmic reticulum (ER) stress repair mechanism. d-T101 peptide has immunostimulatory and anticancer activity, selectively induces apoptosis in proliferating cancer cells and increases IL-2 and IFN-γ expression as well as the recruitment of NK cells and M1 macrophages to the tumor site .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0018

Daidzin 10+ Cited Publications Daidzoside; NPI-031D; Daidzein 7-O-glucoside	Monophenols Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Other Diseases Phenols Plants Disease Research Fields Isoflavones Source Classification	Mitochondrial Metabolism Reverse Transcriptase Aldehyde Dehydrogenase (ALDH)
Daidzin is an isoflavone with antioxidant, anticancer, and antiatherosclerotic activities. Daidzin is a potent and selective inhibitor of mitochondrial ALDH-2. Daidzin reduces ethanol consumption .

HY-N0069

Solamargine 10+ Cited Publications Solamargin; δ-Solanigrine	Alkaloids Piperidine Alkaloids Solanum Classification of Application Fields Solanaceae Plants Disease Research Fields Saccharides Steroids Cancer	P-glycoprotein Apoptosis
Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity .

HY-N0038

Alantolactone 5+ Cited Publications (+)-Alantolactone; Alant camphor; Inula camphor	other families Classification of Application Fields Terpenoids Sesquiterpenes Inula helenium L. Plants Compositae Disease Research Fields Source Classification Cancer	STAT Apoptosis TGF-beta/Smad
Alantolactone is a selective STAT3 inhibitor, with potent anticancer activity. Alantolactone induces apoptosis in cancer .

HY-N1405

Cucurbitacin I Maximum Cited Publications 13 Publications Verification Elatericin B; JSI-124; NSC-521777	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Plants Disease Research Fields Lagenaria siceraria (Molina) Standl. Cancer	STAT JAK
Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity.

HY-N3017

Artemitin 1 Publications Verification	Flavonols Monophenols Flavonoids other families Classification of Application Fields Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Antibiotic
Artemitin is a flavonoid neuroanesthetic agent with moderate cytotoxicity. Artemitint has selective inhibitory activity against Meth-A sarcoma cells with an ED₅₀ of 5-10 μg/mL, and has no significant effect on LLC lung cancer cells. Artemitin exerts anticancer activity by affecting cell proliferation signaling pathways, and also has potential anti-inflammatory and neuroprotective effects. Artemitin exhibits a dose-dependent antinociceptive effect in the mouse hot plate test, with an ED₅₀ of 1.6 μg/kg, and has analgesic activity .

HY-N2229

Rhapontigenin 3 Publications Verification	Infection Stilbenes Classification of Application Fields Leguminosae Phenols Polyphenols Plants Trigonella foenum-graecum Linn. Inflammation/Immunology Disease Research Fields Source Classification	Cytochrome P450 Fungal Bacterial
Rhapontigenin is a natural analog of resveratrol with anticancer, antioxidant, antifungal and antibacterial activities. Rhapontigenin is amechanism-based, potent and selective cytochrome P450 1A1 inactivator (IC₅₀ = 400 nM). Rhapontigenin exhibits 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively .

HY-N8264

Moringin 1 Publications Verification	Structural Classification Natural Products Neurological Disease Classification of Application Fields Moringa oleifera Lam. Moringaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	TRP Channel
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC₅₀ of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities .

HY-N0396

Harpagoside 4 Publications Verification	Iridoids Classification of Application Fields Terpenoids Pedaliaceae Plants Harpagophytum procumbens Inflammation/Immunology Disease Research Fields	COX NO Synthase
Harpagoside can be obtained by Harpagophytum procumbens, which has anti-inflammatory, anti-cancer, protective activity, and efficacy. Harpagoside has an inhibitory effect on COX-1 and COX-2 active, and suppresses NO production. Harpagoside inhibits HepG2 cell lipid polysaccharide, which is a protein that is expressed horizontally and selectively, and has anti-inflammatory and latent pain effects. Harpagoside has the ability to protect the body, and has a degenerative effect on the β-oxidation (Aβ).

HY-N3945

Glaucine O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396	Infection Alkaloids other families Classification of Application Fields Plants Isoquinoline Alkaloids Glaucium flavum Inflammation/Immunology Disease Research Fields Papaveraceae Source Classification	Phosphodiesterase (PDE) Calcium Channel MMP NF-κB
Glaucine (O,O-Dimethylisoboldine) is an alkaloid extracted from Glaucium flavum that possesses various activities, including cough relief, bronchodilation, anti-inflammatory effects, analgesia, antipyretic properties, and anticancer effects. Glaucine acts as a selective and orally active inhibitor of phosphodiesterase 4 (PDE4), with a K_i of 3.4 µM in human bronchial tissues and polymorphonuclear leukocytes. Glaucine induces relaxation of human isolated bronchi by antagonizing calcium channels. Additionally, Glaucine inhibits the activation of NF-κB, leading to a reduction in the expression of the MMP-9 gene, thereby suppressing the migration and invasion of breast cancer cells. Therefore, Glaucine holds potential for research in asthma and breast cancer .

HY-N10457

Norstictic acid	Infection Classification of Application Fields Usnea diffracta Vain. Ketones, Aldehydes, Acids Plants Disease Research Fields Usneaceae Cancer Source Classification	Bacterial
Norstictic acid is a potent and selective allossteric transcriptional regulator. Norstictic acid shows anticancer activity. Norstictic acid shows antioxidant activity and antimicrobial activity .

HY-N0929

Hexahydrocurcumin	Classification of Application Fields Phenols Polyphenols Plants Curcuma longa Disease Research Fields Source Classification Zingiberaceae Cancer	COX Reactive Oxygen Species (ROS)
Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-41404

Piperonylic acid 2H-1,3-benzodioxole-5-carboxylic acid	Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Piperaceae Plants Disease Research Fields Piper nigrum Linn. Source Classification	Cytochrome P450 Interleukin Related EGFR IGF-1R
Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase. Piperonylic acid has anticancer, antioxidant and antibacterial activities .

HY-N6939

Pseudolaric Acid B 2 Publications Verification	Infection Structural Classification Classification of Application Fields Pinaceae Terpenoids Diterpenoids Plants Inflammation/Immunology Disease Research Fields Cancer	HBV Fungal Apoptosis Autophagy Ferroptosis Interleukin Related HIF/HIF Prolyl-Hydroxylase
Pseudolaric Acid B is an orally active diterpene acid. Pseudolaric Acid B has anti-fungal, anti-fertility, anti-angiogenesis and anticancer activity, and can induce tumor cell apoptosis and autophagy. In addition, Pseudolaric Acid B can inhibit the secretion of hepatitis B virus (HBV) and has immunosuppressive effect, selectively inhibiting the proliferation of T lymphocytes and the production of IL-2 .

HY-18979

Lactimidomycin 1 Publications Verification	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Flavivirus Dengue Virus
Lactimidomycin is a glutarimide-containing compound isolated from Streptomyces. Lactimidomycin is a potent inhibitor of eukaryotic translation elongation. Lactimidomycin has a potent antiproliferative effect on tumor cell lines and selectively inhibit protein translation. Lactimidomycin inhibits protein synthesis with an IC₅₀ value of 37.82 nM. Lactimidomycin is also a potent and non-toxic inhibitor of dengue virus 2 and other RNA viruses. Anticancer and antiviral activities .

HY-N2435

[8]-Shogaol 4 Publications Verification	Zingiber officinale Roscoe Monophenols Classification of Application Fields Phenols Plants Disease Research Fields Source Classification Zingiberaceae Cancer	COX Apoptosis
[8]-Shogaol, a kind of stimulating compound in ginger, has antiplatelet (IC₅₀=5 μM), anti-cancer and anti-inflammatory activity. [8]-Shogaol inhibited COX-2 (IC₅₀=17.5 μM), which led to the decline of human leukemia cells. 8-Shogaol Selective direction TAK1 sum TAK1-TAB1 (IC₅₀=5 μM), suppress IKK, Akt sum MAPK signal pathway, and reverse synovitis synovial sum Air dampness (RA).

HY-108485

Damnacanthal	Infection Quinones Monophenols Classification of Application Fields Anthraquinones Morinda citrifolia Linn. Rubiaceae Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Src Apoptosis Fungal
Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56 ^lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 ^lck autophosphorylation and phosphorylation of exogenous substrates with IC₅₀s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against *Candida albicans* .

HY-121382

Gypsogenin	Cardiovascular Disease Triterpenes Structural Classification Classification of Application Fields Terpenoids Plants Disease Research Fields Caryophyllaceae Source Classification Gypsophila perfoliata Linn.	Cholinesterase (ChE) Apoptosis Necroptosis
Gypsogenin is a selective mixed-type BChE inhibitor (K_i=19.99 μM) that also exhibits significant cytotoxicity against various human cancer cell lines. Gypsogenin inhibits tumor growth by inducing cell cycle arrest and triggering apoptosis. Gypsogenin displays antibacterial activity against bacteria such as Bacillus subtilis and Bacillus thuringiensis, and often serves as a key parent nucleus for the synthesis of anticancer compounds. Gypsogenin is widely used in research on Alzheimer's disease and various cancers including colon cancer, melanoma, and leukemia .

HY-B1173

(+)-Camphor 1 Publications Verification D-(+)-Camphor; (1R)-(+)-Camphor	Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Other Diseases Plants Lauraceae Cinnamomum camphora Disease Research Fields Source Classification	Environmental Pollutants Bacterial
(+)-Camphor (D-(+)-Camphor; (1R)-(+)-Camphor) is an isomer of Camphor. Camphor is an agonist of monoterpenoid transient receptor potential (TRP) channels (such as TRPV1, TRPV3, TRPM8) and an inhibitor of TRPA1 channels. Camphor's derivatives have multiple biological activities, including antibacterial, antiviral, antioxidant, analgesic and anticancer. Camphor can selectively activate cold-sensitive TRP channels and inhibit TRPA1-mediated nociceptive signals. Camphor stimulates the cold-sensing nerve endings in the skin and regulates the activity of ion channels to exert analgesic, anti-inflammatory and anti-itching effects. It also has anti-proliferative and anti-mutagenic activities on tumor cells, which may be related to inhibiting ribosome function or inducing cell apoptosis. Camphor can be absorbed through the skin and (+)-Camphor can be used in the study of muscle and joint pain and inflammation .

HY-125938

Cycloartenyl ferulate 1 Publications Verification Cycloartenol ferulate; Cycloartenol ferulic acid ester	Triterpenes Monophenols other families Classification of Application Fields Terpenoids Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Drug Derivative Apoptosis Reactive Oxygen Species (ROS) JAK STAT
Cycloartenyl ferulate (Cycloartenol ferulate; Cycloartenol ferulic acid ester) is a derivative of γ-oryzanol (HY-B2194) with multiple biological activities including antioxidant, anti-inflammatory, and anti-tumor properties. Cycloartenyl ferulate selectively binds to IFNγR1 (binding affinity K_d = 0.5 μM) to activate the canonical JAK1/2-STAT1 signaling pathway. Cycloartenyl ferulate inhibits paraquat (PQ)-triggered apoptosis and ROS in HK2 cells. Cycloartenyl ferulate enhances the activation and cytolytic activity of natural killer (NK) cells by upregulating the expression of NK cell activation receptors (NKG2D, NKp30, NKp44) and the release of cytotoxic molecules and cytokine IFNγ. Cycloartenyl ferulate exerts anti-cancer effects in tumor mice models. Cycloartenyl ferulate can be used for the study of cancer and allergic inflammation intervention .

HY-N0018R

Daidzin (Standard) Daidzoside (Standard); NPI-031D (Standard); Daidzein 7-O-glucoside (Standard)	Structural Classification Monophenols Flavonoids Leguminosae Glycine max (L.) merr Phenols Plants Isoflavones Source Classification	Reference Standards Mitochondrial Metabolism Reverse Transcriptase Aldehyde Dehydrogenase (ALDH)
Daidzin (Standard) is the analytical standard of Daidzin. This product is intended for research and analytical applications. Daidzin is an isoflavone with antioxidant, anticancer, and antiatherosclerotic activities. Daidzin is a potent and selective inhibitor of mitochondrial ALDH-2. Daidzin reduces ethanol consumption .

HY-N11785

Glyceollin I	Structural Classification Monophenols Leguminosae Glycine max (L.) merr Phenols Plants Source Classification	Estrogen Receptor/ERR
Glyceollin I is a selective estrogen receptor (ER) modulator with anticancer, antioxidant, and anti-inflammatory activities. Glyceollin I is promising for research of estrogen-related cancers (e.g., breast, ovarian) and metabolic disorders (e.g., hypercholesterolemia) .

HY-N0929R

Hexahydrocurcumin (Standard)	Structural Classification Phenols Polyphenols Plants Curcuma longa Source Classification Zingiberaceae	Reference Standards COX Reactive Oxygen Species (ROS)
Hexahydrocurcumin (Standard) is the analytical standard of Hexahydrocurcumin. This product is intended for research and analytical applications. Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-N2181A

DL-Acetylshikonin	Quinones Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Boraginaceae	Cytochrome P450
DL-Acetylshikonin is a non-selective, reversible cytochrome P450 inhibitor with IC₅₀ values of 1.4-4.0 μM. DL-Acetylshikonin has anti-cancer and anti-inflammatory activities .

HY-158721

Penicinoline Marinamide	Structural Classification Alkaloids Microorganisms Indole Alkaloids Source Classification	Endogenous Metabolite Parasite
Penicinoline (Marinamide) (Compound 1), a pyrrolyl 4-quinolinone alkaloid, is a microbial secondary metabolite. Penicinoline can be isolated from endophytic fungus Penicillium sp. Penicinoline has antimalarial activity against Chloroquine (HY-17589A) sensitive strain (pf3d7) and against Chloroquine resistant strain (pfDd2) of plasmodium falciparum. Penicinoline also has strong insecticidal activity against Aphis gossypii and selective anticancer effect with significant cytotoxicity for 95-D and HepG2 cells .

HY-N3248

Momordicoside G Momordicacoside G	Triterpenes Terpenoids Cucurbitaceae Plants Source Classification Momordica charantia Linn.	Endogenous Metabolite Reactive Oxygen Species (ROS) Apoptosis
Momordicoside G (Momordicacoside G) is an orally active cucurbitane-type triterpene glycoside. Momordicoside G selectively induces apoptosis of M1-like macrophages, without affecting M2-like macrophages. Momordicoside G reduces intracellular ROS levels and promotes autophagy. Momordicoside G also has anticancer activity, inhibiting the growth of cancer cell lines. Momordicoside G stimulates M2-associated lung injury repair and prevents inflammatory lung cancer injury .

HY-B1173R

(+)-Camphor (Standard) D-(+)-Camphor (Standard); (1R)-(+)-Camphor (Standard)	Structural Classification Other Monoterpenes Terpenoids Plants Lauraceae Cinnamomum camphora Source Classification	Reference Standards Bacterial
(+)-Camphor (Standard) is the analytical standard of (+)-Camphor. This product is intended for research and analytical applications. (+)-Camphor (D-(+)-Camphor; (1R)-(+)-Camphor) is an isomer of Camphor. Camphor is an agonist of monoterpenoid transient receptor potential (TRP) channels (such as TRPV1, TRPV3, TRPM8) and an inhibitor of TRPA1 channels. Camphor's derivatives have multiple biological activities, including antibacterial, antiviral, antioxidant, analgesic and anticancer. Camphor can selectively activate cold-sensitive TRP channels and inhibit TRPA1-mediated nociceptive signals. Camphor stimulates the cold-sensing nerve endings in the skin and regulates the activity of ion channels to exert analgesic, anti-inflammatory and anti-itching effects. It also has anti-proliferative and anti-mutagenic activities on tumor cells, which may be related to inhibiting ribosome function or inducing cell apoptosis. Camphor can be absorbed through the skin and (+)-Camphor can be used in the study of muscle and joint pain and inflammation .

HY-N11919

Anticancer agent 149	Phenols Polyphenols Plants Dioscorea membranacea Pierre ex Prain & Burkill Source Classification Dioscoreaceae	Others
Anticancer agent 149 (compound 3) is an anticancer agent isolated from the rhizome of Dioscorea dioscorea (DM). Anticancer agent 149 exhibits selective cytotoxic activity against MCF-7 cells (IC₅₀=31.41 μM) .

HY-N0038R

Alantolactone (Standard) (+)-Alantolactone (Standard); Alant camphor (Standard); Inula camphor (Standard)	Structural Classification other families Terpenoids Sesquiterpenes Inula helenium L. Plants Compositae Source Classification	Reference Standards STAT Apoptosis TGF-beta/Smad
Alantolactone (Standard) is the analytical standard of Alantolactone. This product is intended for research and analytical applications. Alantolactone is a selective STAT3 inhibitor, with potent anticancer activity. Alantolactone induces apoptosis in cancer .

HY-113627

Undecylprodigiosin	Natural Products Microorganisms Source Classification	Antibiotic Bacterial Apoptosis
Undecylprodigiosin, a member of the family of prodiginines, is a potent antibiotic. Undecylprodigiosin can selectively induce apoptosis in human breast carcinoma cells independent of p53. Undecylprodigiosin shows immunosuppressive, anticancer properties and antimicrobial activities .

HY-N1405R

Cucurbitacin I (Standard) Elatericin B (Standard); JSI-124 (Standard); NSC-521777 (Standard)	Triterpenes Structural Classification Classification of Application Fields Terpenoids Cucurbitaceae Plants Disease Research Fields Lagenaria siceraria (Molina) Standl. Source Classification Cancer	STAT JAK Reference Standards
Cucurbitacin I (Standard) is the analytical standard of Cucurbitacin I. This product is intended for research and analytical applications. Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity.

HY-41404R

Piperonylic acid (Standard) 2H-1,3-benzodioxole-5-carboxylic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Piperaceae Plants Piper nigrum Linn. Source Classification	Cytochrome P450 Interleukin Related EGFR IGF-1R Reference Standards
Piperonylic acid (Standard) is the analytical standard of Piperonylic acid. This product is intended for research and analytical applications. Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase. Piperonylic acid has anticancer, antioxidant and antibacterial activities .

HY-N0069R

Solamargine (Standard) Solamargin (Standard); δ-Solanigrine (Standard)	Structural Classification Alkaloids Piperidine Alkaloids Solanum Solanaceae Plants Saccharides Steroids	P-glycoprotein Reference Standards Apoptosis
Solamargine (Standard) is the analytical standard of Solamargine. This product is intended for research and analytical applications. Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity .

HY-N2229R

Rhapontigenin (Standard)	Structural Classification Stilbenes Leguminosae Phenols Polyphenols Plants Trigonella foenum-graecum Linn. Source Classification	Reference Standards Cytochrome P450 Fungal Bacterial
Rhapontigenin (Standard) is the analytical standard of Rhapontigenin. This product is intended for research and analytical applications. Rhapontigenin is a natural analog of resveratrol with anticancer, antioxidant, antifungal and antibacterial activities. Rhapontigenin is amechanism-based, potent and selective cytochrome P450 1A1 inactivator (IC₅₀ = 400 nM). Rhapontigenin exhibits 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively .

HY-N6939R

Pseudolaric Acid B (Standard)	Structural Classification Pinaceae Terpenoids Diterpenoids Plants	Reference Standards HBV Fungal Apoptosis Autophagy Ferroptosis HIF/HIF Prolyl-Hydroxylase Interleukin Related
Pseudolaric Acid B (Standard) is the analytical standard of Pseudolaric Acid B. This product is intended for research and analytical applications. Pseudolaric Acid B is an orally active diterpene acid. Pseudolaric Acid B has anti-fungal, anti-fertility, anti-angiogenesis and anticancer activity, and can induce tumor cell apoptosis and autophagy. In addition, Pseudolaric Acid B can inhibit the secretion of hepatitis B virus (HBV) and has immunosuppressive effect, selectively inhibiting the proliferation of T lymphocytes and the production of IL-2 .

HY-N0396R

Harpagoside (Standard)	Structural Classification Iridoids Terpenoids Pedaliaceae Plants Harpagophytum procumbens	Reference Standards COX NO Synthase
Harpagoside (Standard) is the analytical standard of Harpagoside. This product is intended for research and analytical applications. Harpagoside can be obtained by Harpagophytum procumbens, which has anti-inflammatory, anti-cancer, protective activity, and efficacy. Harpagoside has an inhibitory effect on COX-1 and COX-2 active, and suppresses NO production. Harpagoside inhibits HepG2 cell lipid polysaccharide, which is a protein that is expressed horizontally and selectively, and has anti-inflammatory and latent pain effects. Harpagoside has the ability to protect the body, and has a degenerative effect on the β-oxidation (Aβ) .

HY-121382R

Gypsogenin (Standard)	Triterpenes Structural Classification Terpenoids Plants Caryophyllaceae Source Classification Gypsophila perfoliata Linn.	Reference Standards Apoptosis Cholinesterase (ChE) Necroptosis
Cinosulfuron (Standard) is the analytical standard of Cinosulfuron. This product is intended for research and analytical applications. Gypsogenin is a selective mixed-type BChE inhibitor (K_i=19.99 μM) that also exhibits significant cytotoxicity against various human cancer cell lines. Gypsogenin inhibits tumor growth by inducing cell cycle arrest and triggering apoptosis. Gypsogenin displays antibacterial activity against bacteria such as Bacillus subtilis and Bacillus thuringiensis, and often serves as a key parent nucleus for the synthesis of anticancer compounds. Gypsogenin is widely used in research on Alzheimer's disease and various cancers including colon cancer, melanoma, and leukemia .

HY-N2435R

[8]-Shogaol (Standard)	Zingiber officinale Roscoe Structural Classification Monophenols Phenols Plants Source Classification Zingiberaceae	Reference Standards COX Apoptosis
-Shogaol (Standard) is the analytical standard of -Shogaol. This product is intended for research and analytical applications. -Shogaol, a kind of stimulating compound in ginger, has antiplatelet (IC₅₀=5 μM), anti-cancer and anti-inflammatory activity. -Shogaol inhibited COX-2 (IC₅₀=17.5 μM), which led to the decline of human leukemia cells. 8-Shogaol Selective direction TAK1 sum TAK1-TAB1 (IC₅₀=5 μM), suppress IKK, Akt sum MAPK signal pathway, and reverse synovitis synovial sum Air dampness (RA) .

HY-N16691

Acrovestone	Structural Classification Ketones, Aldehydes, Acids Rutaceae Phenols Plants Acronychia pedunculata (L.) Miq. Source Classification	Others
Acrovestone (compound 4) is an Acronychia-type acetophenone dimer and a selective anticancer agent. Acrovestone has IC₅₀ values ??of 0.38 μM and 0.93 μM against A2058 melanoma cells and DU145 prostate cancer cells, respectively. Acrovestone shows low inhibitory activity against normal human dermal fibroblasts (NHDF), with an IC₅₀ >5 μM. Acrovestone can be used in anticancer research related to prostate cancer and melanoma. Acrovestone can be naturally extracted from the trunk bark of Acronychia pedunculata .

HY-N16746

Nordentatin	Structural Classification Rutaceae Coumarins Phenylpropanoids Plants Clausena excavata N. L. Burman Source Classification	GSK-3 Bcl-2 Family MMP Caspase
Nordentatin is a selective inhibitor targeting GSK-3 with anticancer activity. Nordentatin can inhibit the phosphorylation of GSK-3, downregulate the anti-apoptotic protein Mcl-1 and activate caspase-3 to induce apoptosis (apoptosis). Nordentatin also inhibits the expression of migration-related protein MMP-9 and exerts anti-proliferation and anti-migration activities. Nordentatin is used in research into cancers such as neuroblastoma .

HY-W714047

Valerianol	Structural Classification Terpenoids Sesquiterpenes Piperaceae Plants Piper mikanianum (Kunth) Steud. Source Classification	EBV Bacterial
Valerianol is a sesquiterpene alcohol with anticancer, antibacterial, and antiviral activities. Valerianol selectively inhibits TPA (HY-18739)-induced Epstein-Barr virus early antigen (EBV-EA) activation (IC₅₀=300 μM). Valerianol inhibits tumor promoter-mediated EBV-EA activation and also inhibits pathogenic bacteria such as Staphylococcus aureus .

HY-N18301

Americanin A	Structural Classification Monophenols Phenols Plants Phytolacca americana L. Phytolaccaceae Source Classification	ATM/ATR Checkpoint Kinase (Chk) MDM-2/p53 E1/E2/E3 Enzyme CDK Mitosis Reactive Oxygen Species (ROS) Apoptosis
Americanin A is a Neolignan. Americanin A can be isolated from the seeds of Phytolacca americana. Americanin A activates ATM and ATR, initiating the subsequent signal transduction cascades that include Chk1, Chk2, and tumor suppressor p53. Americanin A targets selectively Skp2 for degradation and thereby stabilizes p27. Americanin A suppresses the activity of Cyclin B1 and its partner cdc2 to prevent entry into Mitosis. Americanin A induces Apoptosis by producing excessive ROS. Americanin A has anti-cancer activity against colorectal cancer .

HY-N16733

Deacetyltanghinin	Apocynaceae Structural Classification Cardiacglycosides Cerbera odollam Gaertn. Plants Steroids Source Classification	Na+/K+ ATPase Apoptosis Caspase Prostaglandin Receptor
Deacetyltanghinin is a selective inhibitor targeting Na ⁺/K ⁺ ATPase, acting through non-covalent binding but is highly cardiotoxic. Deacetyltanghinin inhibits Na ⁺/K ⁺ ATPase activity, induces cancer cell apoptosis (involving caspase pathway activation), and at the same time affect the TXA2-PGI2 balance in the rabbit heart. Deacetyltanghinin has significant anti-cancer activity and is mainly used in the research field of targeted therapy of malignant tumors such as breast cancer and lung cancer. At the same time, attention should be paid to the regulation of its cardiotoxicity .

HY-N14094

Tubulosine	Structural Classification Alkaloids Other Alkaloids Rubiaceae Plants Pogonopus tubulosus (A.Rich. ex DC.) K.Schum. Source Classification	JAK Apoptosis Autophagy
Tubulosine is an alkaloid. Tubulosine can be isolated from Pogonopus tubulosus (DC.) Schumann. Tubulosine is an ATP-competitive, selective JAK3 inhibitor with an IC₅₀ value of 9.9 nM. Tubulosine also inhibits the kinase activities of other JAK family members, the extent of inhibition is less than that of JAK3, with IC₅₀ values of 69.5, 84.9 and 76.3 nM for JAK1, JAK2 and TYK2, respectively. Tubulosine selectively inhibits JAK3 signalling by binding to the ATP-binding site of the kinase of JAK3. Tubulosine induces apoptotic and necrotic/autophagic cell death. Tubulosine inhibits the process of peptide chain elongation by eukaryotic polysomes by, specifically preventing the elongation-factor-2-dependent step of translocation. Tubulosine exhibits anticancer activity in breast cancer cells .

HY-N17778

(2R,3R)-7,3',4'-Trihydroxy-5-methoxy-flavanonol	Structural Classification Flavonols Flavonoids Leguminosae Genista corsica (Loisel.) DC. Plants Source Classification	Others
(2R,3R)-7,3',4'-Trihydroxy-5-methoxy-flavanonol is a flavonoid and a selective inhibitor of human liver cancer cell growth, with an IC₅₀ of 38.6 μg/mL (121.5 μM). (2R,3R)-7,3',4'-Trihydroxy-5-methoxy-flavanonol inhibits cancer cell growth with dose-dependent cytotoxic activity, and its anticancer activity is comparable to that of Cisplatin (HY-17394). (2R,3R)-7,3',4'-Trihydroxy-5-methoxy-flavanonol can be used in research on liver cancer and other types of cancer.

Cat. No.	Product Name	Chemical Structure

HY-10218S

Everolimus-d4
Everolimus-d₄ is the deuterium labeled Everolimus. Everolimus (RAD001) is a Rapamycin derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities .

HY-14914S1

Azilsartan-d4
Azilsartan-d₄ is the deuterium labeled Azilsartan . Azilsartan is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research .

HY-10218S1

Everolimus-13C2,d4

Everolimus- ¹³C₂,d₄ (RAD001- ¹³C₂,d₄) is ¹³C labeled Everolimus. Everolimus (RAD001) is a Rapamycin (HY-10219) derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities .

HY-W745860

Hexahydrocurcumin-d6
Hexahydrocurcumin-d₆ is the deuterium labeled Hexahydrocurcumin (HY-N0929). Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-149773S

HPK1-IN-40-d2
HPK1-IN-40 (compound 49) is a potent and selective HPK1 inhibitor with an IC₅₀ of 0.9 nM. HPK1-IN-40 reinvigorates T-cell receptor (TCR) signaling, promoting T-cell function and cytokine production in T cells while having anti-cancer activity .

HY-W759629

Selpercatinib-d3
Selpercatinib-d₃ (LOXO-292-d₃) is deuterium labeled Selpercatinib. Selpercatinib (LOXO-292) is a potent, selective RET kinase inhibitor with IC₅₀ values of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively. Selpercatinib has anticancer activity .

HY-114370S

Selpercatinib-13C,d3
Selpercatinib- ¹³C,d₃ (LOXO-292- ¹³C,d₃) is ¹³C labeled Selpercatinib. Selpercatinib (LOXO-292) is a potent, selective RET kinase inhibitor with IC₅₀ values of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively. Selpercatinib has anticancer activity .

HY-B0689S1

Indinavir-13C4,15N

Indinavir- ¹³C₄, ¹⁵N (MK-639 (free base)- ¹³C₄, ¹⁵N) is ¹³C and ¹⁵N labeled Indinavir. Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a K_i of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CL ^pro inhibitor .

Cat. No.	Product Name		Classification

HY-181534

PROTAC TEAD1/IAP degrader-1		PROTAC Synthesis
PROTAC TEAD1/IAP degrader-1 (Compound A232) is a selective TEAD1 and cIAP1 PROTAC degrader, with DC₅₀ values of 14 nM and 270 nM, respectively. PROTAC TEAD1/IAP degrader-1 promotes the ubiquitination and degradation of TEAD1 and cIAP1. PROTAC TEAD1/IAP degrader-1 downregulates the expression of the TEAD-dependent gene CTGF. PROTAC TEAD1/IAP degrader-1 exhibits anticancer activity against mesothelioma .

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