2 Results for "

skeletal muscle toxicity

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "skeletal muscle toxicity" in MCE Product Catalog:

3
p-Synephrine
p-Synephrine
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3 Cited Publications
Cat. No.: HY-113236
CAS No.: 614-35-7
Purity:  98.04%
Category:  

Citrus × aurantium Linnaeus Rutaceae Plants Endogenous metabolite Alkaloids Monophenols Other Alkaloids Other Diseases Phenols Disease Research Fields

Target:  

Adrenergic Receptor AMPK GLUT p38 MAPK NF-κB

p-Synephrine is an orally active alkaloid dietary supplement without indirect sympathomimetic activity or cardiovascular stimulatory activity. p-Synephrine stimulates AMPK phosphorylation and mediates Glut4 translocation to increase glucose consumption and lactate production in skeletal muscle cells. p-Synephrine also downregulates the p38 MAPK and NF-κB signaling pathways to inhibit pro-inflammatory cytokine production and alter oxidative metabolism. p-Synephrine exhibits low subchronic toxicity in mice. p-Synephrine can be applied to research related to systemic inflammatory response syndrome, obesity, and type 2 diabetes .
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(±)-Hexanoylcarnitine chloride
(±)-Hexanoylcarnitine chloride
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Cat. No.: HY-100978
CAS No.: 6920-35-0
Purity:  ≥98.0%
Synonyms: DL-Hexanoylcarnitine chloride
Category:  

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

(±)-Hexanoylcarnitine chloride is a fatty acid metabolite that breaks down fatty acids into energy that can be used by the body. (±)-Hexanoylcarnitine chloride also serves as a specific and easily detectable biomarker for rat skeletal muscle toxicity. Cerivastatin (HY-129458) and TMPD (HY-W012145) induce an increase in Hexanoylcarnitine in rats in a metabolomic analysis of the rectus femoris muscle. In type 2 diabetes, Hexanoylcarnitine is also significantly associated with and improves prediction of all-cause mortality. Hexanoylcarnitine is a biomarker for the identification of novel pathogenic pathways .
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