83 Results for "

sponge

" in MedChemExpress (MCE) Product Catalog:
Products (83)

83 Results for "sponge" in MCE Product Catalog:

13
Latrunculin A
Latrunculin A
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13 Publications Verification
製品番号: HY-16929
CAS 番号: 76343-93-6
別名: LAT-A
Category:  

Animals Macrolide Antibiotics Antibiotics Marine natural products Other Diseases Sponge Disease Research Anticancer Disease Research Fields

Target:  

Arp2/3 Complex

Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with Kds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration .
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9
Jasplakinolide
Jasplakinolide
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9 Cited Publications
製品番号: HY-P0027
CAS 番号: 102396-24-7
Category:  

Antifungal Marine natural products Disease Research Other Antibiotics Infection Monophenols Animals Antibiotics Cyclopeptides Phenols Sponge Anticancer Disease Research Fields

Target:  

Arp2/3 Complex Fungal

Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity .
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2
Aaptamine
Aaptamine
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2 Cited Publications
製品番号: HY-N4225
CAS 番号: 85547-22-4
Category:  

Alkaloids Animals Marine natural products Quinoline Alkaloids Sponge Disease Research Fields Endocrinology

Target:  

Adrenergic Receptor Proteasome Cholinesterase (ChE) Bacterial Apoptosis AP-1 NF-κB

Aaptamine is an alkaloid that can be isolated from the sponge Aaptos suberitoides. Aaptamine is a competitive antagonist of the α-adrenergic receptor, as well as an inhibitor of the proteasome and cholinesterase. Aaptamine is cytotoxic to tumor cells and can induce apoptosis, cell cycle arrest of tumor cells, and the expression of p21 through a p53-independent pathway. Aaptamine has multiple activities such as anti-tumor, antioxidant, antibacterial, and analgesic effects .
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2
Ilimaquinone
Ilimaquinone
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2 Cited Publications
製品番号: HY-119500
CAS 番号: 71678-03-0
純度:  ≥98.0%
Category:  

Infection Quinones Animals Marine natural products Benzene Quinones Sponge Disease Research Fields Inflammation/Immunology Cancer

Target:  

HIV Bacterial

Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus . Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects .
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1
Ergosterol peroxide
Ergosterol peroxide
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1 Cited Publications
製品番号: HY-N3845
CAS 番号: 2061-64-5
Category:  

天然物 Orchidaceae Plants Disease Research Fields Inflammation/Immunology Anoectochilus elwesii

Target:  

Bacterial

Ergosterol peroxide is a steroid derivative and can be isolated from a variety of fungi, yeast, lichens or sponges. Ergosterol peroxide has anti-tumour, proapoptotic, anti-inflammatory, anti-mycobacterial, and anti-proliferative activities .
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1
1-beta-D-Arabinofuranosyluracil
1-beta-D-Arabinofuranosyluracil
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1 Cited Publications
製品番号: HY-N6652
CAS 番号: 3083-77-0
別名: Uracil 1-β-D-arabinofuranoside
Category:  

Cardiovascular Disease 天然物 Animals Marine natural products Disease Research Fields Inflammation/Immunology

Target:  

Others

1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties . 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells .
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Aeroplysinin 1
Aeroplysinin 1
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1 Cited Publications
製品番号: HY-19827
CAS 番号: 28656-91-9
別名: (+)-Aeroplysinin-1
Category:  

Anti-inflammation/Immunoregulatory Marine natural products Disease Research Antibacterial Other Antibiotics Infection Animals Antibiotics Antiviral Sponge Anticancer Disease Research Fields

Target:  

Bacterial HIV Apoptosis

Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells .
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Fascaplysin
Fascaplysin
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製品番号: HY-112328
CAS 番号: 114719-57-2
Category:  

Infection Alkaloids Animals Marine natural products Sponge Disease Research Fields Cancer Indole Alkaloids

Target:  

Apoptosis Autophagy Reactive Oxygen Species (ROS) CDK

Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity .
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Nonadecanoic acid
Nonadecanoic acid
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製品番号: HY-W004261
CAS 番号: 646-30-0
Category:  

other families Ketones, Aldehydes, Acids Other Diseases Plants Disease Research Fields

Target:  

Endogenous Metabolite Interleukin Related Ser/Thr Protease Thrombin

Nonadecanoic acid is a 19-carbon long saturated fatty acid. Nonadecanoic acid is the major constituent of the substance secreted by Rhinotermes marginalis. Nonadecanoic acid can be isolated from several sources, including fungus, plant, and marine sponge. Nonadecanoic acid exhibits inhibitory effects on fibrinolysis and plasmin activity. Nonadecanoic acid produced from Streptomyces is an anti-tumor agent and inhibits IL-12 production .
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Naamidine J
Naamidine J
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製品番号: HY-N14001
CAS 番号: 2227550-73-2
Category:  

Alkaloids Marine natural products Sponge Imidazole Alkaloids

Target:  

TNF Receptor Interleukin Related Arginase PD-1/PD-L1

Naamidine J is an imidazole-type alkaloids discovered in a sponge. Naamidine J inhibits inflammation by binding to the protein CSE1L (KD = 5.41 μM). Namidine J significantly inhibits the expression of pro-inflammatory factors such as TNF-α, IL-1β, and IL-6, and upregulates anti-inflammatory factors such as CD206 and Arg-1. Namidine J inhibits PD-L1 and shows antitumor activity. Namidine J significantly reduces pulmonary tissue edema, inflammatory cell infiltration and cytokine storm in mice. Namidine J can be used for the research on the immune microenvironment of acute lung injury and tumors .
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Deoxytopsentin
Deoxytopsentin
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製品番号: HY-N15451
CAS 番号: 112515-42-1
Category:  

Alkaloids Marine natural products Sponge Indole Alkaloids

Target:  

Pyruvate Kinase

Deoxytopsentin (compound 5) is a marine bisindole alkaloid and also a MRSA pyruvate kinase inhibitor. Deoxytopsentin exists in sponges. Deoxytopsentin exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus strains in vitro .
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Methyl 5-bromo-1H-pyrrole-2-carboxylate
Methyl 5-bromo-1H-pyrrole-2-carboxylate
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製品番号: HY-W006646
CAS 番号: 934-07-6
Category:  

Alkaloids Pyrrole Alkaloids Marine natural products Sponge

Target:  

Biochemical Assay Reagents

Methyl 5-bromo-1H-pyrrole-2-carboxylate (Compound 7) is a pyrrole that can be isolated from marine sponges Lissodendotyx sp.
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Viomellein
Viomellein
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製品番号: HY-123888
CAS 番号: 55625-78-0
Category:  

Microorganisms Phenols Polyphenols

Target:  

E1/E2/E3 Enzyme Bacterial

Viomellein is a SUMOylation inhibitor with antibacterial and anticancer activities. Viomellein inhibits biofilm formation of strains produced from the fungus Aspergillus ochraceus from the Mediterranean sponge Agelas oroides. Viomellein exhibits cytotoxicity against A2780 human ovarian cancer cells with an IC50 value of 5.0 μM. Viomellein also inhibits SUMOylation of RanGAP1 (GTPase activating protein) with an IC50 of 10.2 μM .
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1-beta-D-Arabinofuranosyluracil (Standard)
1-beta-D-Arabinofuranosyluracil (Standard)
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製品番号: HY-N6652R
CAS 番号: 3083-77-0
別名: Uracil 1-β-D-arabinofuranoside (Standard)
Category:  

天然物 Animals

Target:  

Reference Standards Others

1-beta-D-Arabinofuranosyluracil (Standard) is the analytical standard of 1-beta-D-Arabinofuranosyluracil. This product is intended for research and analytical applications. 1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties . 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells .
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Pelorol
Pelorol
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製品番号: HY-N15748
CAS 番号: 287974-44-1
別名: (-)-Pelorol
Category:  

Terpenoids Sesquiterpenes Marine natural products Sponge

Target:  

Parasite

Pelorol ((-)-Pelorol) is a sesquiterpene found in the tropical marine sponge Dactylospongia elegans. Pelorol has weak antitrypanosomal activity with an IC50 of 17.4 μg/mL and antiplasmodial activity against Plasmodium falciparum clones K1 and NF54 with IC50 values of 786 ng/mL and 1911 ng/mL, respectively. Pelorol is promising for research of parasitic diseases, such as trypanosomiasis and malaria .
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IZ-Chol
IZ-Chol
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製品番号: HY-159859
CAS 番号: 191990-35-9
Target:  

Liposome

研究分野:  

Others

IZ-Chol (IZ-Cholesterol) is an ionizable cationic lipid containing cholesterol. IZ-Chol-LNPs is highly potential to effectively complex with DNA, and endosome escape mechanisms mediated by proton sponge effect .
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Avarol
Avarol
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製品番号: HY-121794
CAS 番号: 55303-98-5
別名: (+)-Avarol
Category:  

Monophenols Marine natural products Phenols

Target:  

Apoptosis NF-κB

Avarol is a sesquiterpene hydroquinone that can be isolated from Dysidea avara sponge. Avarol has the potential for the research of ehrlich carcinoma (EC) and cervical cancer (CC-5) .
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Cyclo(prolyltyrosyl)
Cyclo(prolyltyrosyl)
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製品番号: HY-N12524
CAS 番号: 5654-84-2
Category:  

Alkaloids Pyrrole Alkaloids Endogenous metabolite

Target:  

Bacterial

Cyclo(prolyltyrosyl) is a natural compound that can be found in various microorganisms and marine sponges. Cyclo(prolyltyrosyl) has antibacterial, phytotoxic and cytotoxic properties .
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Agelastatin A
Agelastatin A
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製品番号: HY-125132
CAS 番号: 152406-28-5
別名: (-)-Agelastatin A; AglA
Category:  

Alkaloids Animals Other Alkaloids

Target:  

Apoptosis

Agelastatin A ((-)-Agelastatin A; AglA), a tetracyclic alkaloid isolated from the sponge Agelas dendromorpha, induces apoptosis and arrests cells in the G2/M phase of the cell cycle, exhibiting antitumor activity .
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Makaluvamine A
Makaluvamine A
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製品番号: HY-125580
CAS 番号: 146555-78-4
Target:  

Topoisomerase

研究分野:  

Cancer

Makaluvamine A is a member of Makaluvamines. Makaluvamines can be isolated from Fijian sponges of the genus Zyzzya, and possess inhibitory activity toward topoisomerase II along with cytotoxic activity against HCT-116 human colon cancer cells .
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