112515-42-1
112515-42-1
Chemical Structure
Deoxytopsentin
- CAS No.: 112515-42-1
- Formula:C20H14N4O
- Molecular Weight:326.35
InChIKey: OBDUUEITYHUFCW-UHFFFAOYSA-N
SMILES: O=C(C1=CNC2=C1C=CC=C2)C3=NC=C(C4=CNC5=C4C=CC=C5)N3
Biological Activity: Deoxytopsentin (compound 5) is a marine bisindole alkaloid and also a MRSA pyruvate kinase inhibitor. Deoxytopsentin exists in sponges. Deoxytopsentin exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus strains in vitro[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Deoxytopsentin | 99.42% | Deoxytopsentin (compound 5) is a marine bisindole alkaloid and also a MRSA pyruvate kinase inhibitor. Deoxytopsentin exists in sponges. Deoxytopsentin exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus strains in vitro. | ||||||||||||||||||||
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References
- [1]. Veale CG, et al. Synthetic analogues of the marine bisindole deoxytopsentin: potent selective inhibitors of MRSA pyruvate kinase. J Nat Prod. 2015;78(3):355-362. [Content Brief]
- [2]. Saïd Achab, et al. A three-component coupling approach to the marine bis-indole alkaloids: Topsentin, deoxytopsentin and bromotopsentin. Tetrahedron Letters. Volume 37, Issue 31, 29 July 1996, Pages 5503-5506.
Keywords
