180 Results for "

trifluoromethyl

" in MedChemExpress (MCE) Product Catalog:
Products (180)

180 Results for "trifluoromethyl" in MCE Product Catalog:

6
6 Publications Verification
Cat. No.: HY-108611
CAS No.: 149301-79-1
Purity:  ≥99.0%
Synonyms: Arachidonyl trifluoromethyl ketone
Target:  

Phospholipase

Research Areas:  

Cardiovascular Disease

AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease .
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2
2 Cited Publications
Cat. No.: HY-W013962
CAS No.: 114926-38-4
Research Areas:  

Others

4-(Trifluoromethyl)-L-phenylalanine is a phenylalanine derivative .
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2
2 Cited Publications
Cat. No.: HY-156048
CAS No.: 1854086-05-7
Purity:  99.12%
Synonyms: TFMT
Target:  

Influenza Virus

Research Areas:  

Infection

Trifluoromethyl-tubercidin (TFMT) is an inhibitor of 2'-O-ribose methyltransferase 1 (MTr1). Trifluoromethyl-tubercidin can inhibit the replication of influenza A and B viruses by interfering with the cap-snatching process of the influenza virus. Trifluoromethyl-tubercidin has antiviral activity and low toxicity .
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1
1 Cited Publications
Cat. No.: HY-D0981
CAS No.: 53518-15-3
Synonyms: Coumarin 151; AFC
7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a fluorescent marker for the sensitive detection of proteinases. The excitation and emission wavelengths are 400 and 490 nm, respectively.
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1
1 Cited Publications
Cat. No.: HY-134124
CAS No.: 92614-59-0
Purity:  95.8%
Research Areas:  

Metabolic Disease

Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .
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1
1 Cited Publications
Cat. No.: HY-P1108
CAS No.: 681260-70-8
Target:  

CRFR

Astressin 2B is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC50=0.57 nM). Astressin 2B blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 .
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1
1 Cited Publications
Cat. No.: HY-P1108A
Target:  

CRFR

Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC50=0.57 nM). Astressin 2B TFA blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B TFA reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B TFA also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B TFA mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B TFA is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 .
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1
1 Cited Publications
Cat. No.: HY-12504
CAS No.: 245747-08-4
Purity:  98.47%
Synonyms: N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide
Target:  

CRAC Channel

Research Areas:  

Others

Pyr6 is a selective store operated calcium entry (SOCE) inhibitor with an IC50 of 0.49 μM. Pyr6 displays 37-fold higher potency for RBL SOCE than for TRPC3 ROCE .
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1 Cited Publications
Cat. No.: HY-A0248A
CAS No.: 4135-11-9
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .
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Cat. No.: HY-Y0147
CAS No.: 81290-20-2
Research Areas:  

Others

Trimethylsilyl(trifluoromethyl)silane is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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Cat. No.: HY-34781
CAS No.: 84392-17-6
Target:  

Drug Derivative

4'-Trifluoromethyl-2-biphenyl carboxylic acid is an orally active hypolipidemic agent .
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Cat. No.: HY-W008510
CAS No.: 69034-12-4
Target:  

Drug Intermediate STAT

Research Areas:  

Others

2-Chloro-5-(trifluoromethyl)pyrimidine is a chemical intermediate. It can be used in the synthesis of inducers of intracellular STAT1 phosphorylation .
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Cat. No.: HY-76574
CAS No.: 454-89-7
Target:  

Drug Intermediate

Research Areas:  

Cancer

3-(Trifluoromethyl)benzaldehyde is a key intermediate in organic synthesis. 3-(Trifluoromethyl)benzaldehyde can be used to synthesize 2,3-di- and 2,2,3-trisubstituted-3-methoxycarbonyl-γ-butyrolactones .
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Cat. No.: HY-D0149
CAS No.: 575-03-1
4-(Trifluoromethyl)umbelliferone is fluorescent probe substrate for rat hepatic cytochrome P450 enzymes .
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Cat. No.: HY-W014566
CAS No.: 88-30-2
Synonyms: 3-(trifluoromethyl)-4-Nitrophenol; TFM
4-Nitro-3-(trifluoromethyl)phenol (TFM) is a piscicide that is toxic to lampreys (P. marinus) (LC50 values are 1.97-2.11 for cysts, 2.05-2.21 for fry, 1.6-2.45 for juveniles, and 1.6-1.63 for adults, respectively). 4-Nitro-3-(trifluoromethyl)phenol is also toxic to juvenile lake sturgeons (A. fulvescens) less than 100 mm, but is nontoxic to a variety of other fish species. 4-Nitro-3-(trifluoromethyl)phenol (50 μM) dissociates oxidative phosphorylation by 22% and 28% in isolated livers of lampreys and rainbow trout (O. mykiss), respectively. 4-Nitro-3-(trifluoromethyl)phenol can be used to control lamprey larval populations.
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Cat. No.: HY-W002441
CAS No.: 175205-81-9
2-Bromo-4-(trifluoromethyl)pyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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Cat. No.: HY-W027773
CAS No.: 575-04-2
Synonyms: MFC
7-Methoxy-4-(trifluoromethyl)coumarin (MFC) is a fluorescent substrate for cytochrome P450 and can quantify CYP activity .
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Cat. No.: HY-66035
CAS No.: 158063-66-2
Synonyms: 4-(trifluoromethyl)pyridine-3-carboxylic acid
Target:  

Parasite

Research Areas:  

Infection

4-(Trifluoromethyl)nicotinic acid (4-(Trifluoromethyl)pyridine-3-carboxylic acid) is a metabolite of the pyridinecarboxamide insecticide Flonicamid (HY-119649) .
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Cat. No.: HY-66029
CAS No.: 231291-22-8
6-(Trifluoromethyl)nicotinic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. 6-(Trifluoromethyl)nicotinic acid is a small heterocyclic molecule containing carboxylic acid and trifluoromethyl groups, which can be used as a multifunctional additive .
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Cat. No.: HY-W267897
CAS No.: 220001-53-6
Synonyms: 7-BFC
Research Areas:  

Others

7-Benzyloxy-4-(trifluoromethyl) coumarin (7-BFC) is a coumarin-based fluorescent substrate. 7-Benzyloxy-4-(trifluoromethyl) coumarin serves as a substrate for cDNA-expressed CYP1A2 and CYP3A4, and is metabolized into 7-hydroxy-4-trifluoromethylcoumarin (HFC). 7-Benzyloxy-4-(trifluoromethyl) coumarin supports metabolic studies of cytochrome P450 subtypes via its fluorescent metabolite .
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