5 Results for "

trigeminal neuropathic pain

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "trigeminal neuropathic pain" in MCE Product Catalog:

1
7,8-Dimethoxycoumarin
7,8-Dimethoxycoumarin
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1 Cited Publications
Cat. No.: HY-N4280
CAS No.: 2445-80-9
Category:  

Rutaceae Coumarins Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology Citrus reticulata Blanco

Target:  

Na+/K+ ATPase Glutathione Peroxidase NF-κB p38 MAPK Interleukin Related

7,8-Dimethoxycoumarin is a coumarin compound derived from Artemisia caruifolia with oral activity. 7,8-Dimethoxycoumarin inhibits mitochondrial permeability transition pore and H +/K +-ATPase, and exhibits antioxidant, anti-inflammatory, renoprotective, neuroprotective and gastroprotective effects. 7,8-Dimethoxycoumarin reduces lipid peroxidation (TBARS), increases GSH levels, inhibits myeloperoxidase (MPO) activity, and regulates the expression of inflammatory factors by inhibiting the NF‑κB and MAPK pathways. 7,8-Dimethoxycoumarin ameliorates gastric mucosal injury, alleviates renal tissue lesions and relieves neuropathic pain. 7,8-Dimethoxycoumarin can be used in studies related to acute renal failure, trigeminal neuralgia and gastritis .
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Levomenol
Levomenol
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Cat. No.: HY-N6967
CAS No.: 23089-26-1
Synonyms: (-)-α-Bisabolol
Category:  

other families Terpenoids Sesquiterpenes Plants

Target:  

Environmental Pollutants Apoptosis

Levomenol ((-)-α-Bisabolol), a monocyclic sesquiterpene alcohol, exerts antioxidant, anti-inflammatory, and anti-apoptotic activities. Levomenol also has neuroprotective effects and prevents neuronal damage and memory deficits through reduction of proinflammatory markers induced by permanent focal cerebral ischemia in mice. Levomenol attenuates nociceptive behaviour and central sensitisation in a rodent model of trigeminal neuropathic pain. Orally active .
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Phrixotoxin 2
Phrixotoxin 2
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Cat. No.: HY-P2786A
CAS No.: 741738-57-8
Target:  

Potassium Channel

Research Areas:  

Neurological Disease

Phrixotoxin 2 is a Kv4 family potassium channel inhibitor, with Ki values in rats of 120 nM for Kv4.2, 110 nM for Kv4.3, and 230 nM for Kv4.1. Phrixotoxin 2 mediates voltage-dependent inhibition of Kv4.2 and Kv4.3 currents, and voltage-independent inhibition of Kv4.1 currents. Phrixotoxin 2 fails to inhibit A-type K + currents in visceral dorsal root ganglion neurons. Phrixotoxin 2 induces contraction of non-pregnant uterine smooth muscle and triggers orofacial cold hyperalgesia in rats. Phrixotoxin 2 can distinguish the contribution of Kv4 subunits to A-type K + currents in different subsets of sensory neurons. Phrixotoxin 2 can be used in research related to chronic pain and trigeminal neuropathic pain .
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ADM 12
ADM 12
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Cat. No.: HY-124277
CAS No.: 1644134-60-0
Target:  

TRP Channel

Research Areas:  

Neurological Disease

ADM 12 is a highly selective transient receptor potential ankyrin 1 (TRPA1) channel antagonist. ADM 12 blocks nitroglycerin (NTG)-induced trigeminal hyperalgesia in animal models, reducing expression of pain-related genes (c-Fos, TRPA1) and neuropeptides (CGRP, SP). ADM_12 is promising for research of migraine and neuropathic pain .
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Levomenol (Standard)
Levomenol (Standard)
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Cat. No.: HY-N6967R
CAS No.: 23089-26-1
Synonyms: (-)-α-Bisabolol (Standard)
Category:  

other families Terpenoids Sesquiterpenes Plants

Target:  

Reference Standards Apoptosis

Levomenol (Standard) is the analytical standard of Levomenol. This product is intended for research and analytical applications. Levomenol ((-)-α-Bisabolol), a monocyclic sesquiterpene alcohol, exerts antioxidant, anti-inflammatory, and anti-apoptotic activities. Levomenol also has neuroprotective effects and prevents neuronal damage and memory deficits through reduction of proinflammatory markers induced by permanent focal cerebral ischemia in mice. Levomenol attenuates nociceptive behaviour and central sensitisation in a rodent model of trigeminal neuropathic pain. Orally active .
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