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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
197 Results for "
zinc-finger
" in MedChemExpress (MCE) Product Catalog:
Products (197)
197 Results for "zinc-finger" in MCE Product Catalog:
27
3
3 Cited Publications
Cat. No.: HY-163731
CAS No.: 3077196-25-6
Research Areas:
EGR-1-IN-1 is a EGR-1 inhibitor with an IC50 of 1.86 μM. EGR-1-IN-1 binds to the zinc finger DNA-binding domain of EGR-1 and promotes the dissociation of the EGR-1-DNA complex. EGR-1-IN-1 reduces the mRNA expression levels of EGR-1-regulated inflammatory genes induced by TNFα. EGR-1-IN-1 alleviates atopic dermatitis-like lesions in the ear skin of mice. EGR-1-IN-1 serves as a lead compound for the development of targeted compounds for inflammatory skin diseases. EGR-1-IN-1 can be used in studies related to atopic dermatitis .
3
3 Cited Publications
Target:
Research Areas:
USP5-IN-1 (compound 64) is a selective competitive inhibitor of USP5 zinc finger ubiquitin binding domain (ZnF-UBD) (KD=2.8 μM). USP5-IN-1 competitively blocks the binding of ubiquitin to ZnF-UBD, inhibits the catalytic activity of USP5, and thus hinders the hydrolysis of ubiquitin chains. USP5-IN-1 can inhibit USP5 cleavage of Lys48-linked diubiquitin substrates in vitro and is a potential USP5 chemical probe and potential inhibitor of USP5-related cancers.
2
2 Cited Publications
Cat. No.: HY-N2112
CAS No.: 79498-31-0
1
1 Cited Publications
Cat. No.: HY-155938
CAS No.: 2801702-34-9
Target:
Research Areas:
Cyano-myracrylamide is an inhibitor of zinc finger DHHC domain-containing palmitoyltransferase 20 (zDHHC20) with an IC50 value of 1.35 µM. Cyano-myracrylamide also inhibits the S-Acylation of EGFR and CD36. Cyano-myracrylamide also inhibits S-acylation of Legionella E3 ligase GobX, MyD88, and Ras, which are substrates of zDHHC20, zDHHC9, and zDHHC6, respectively, in HEK293T cells expressing recombinant Legionella GobX, recombinant human MyD88, or endogenous Ras .
1
1 Cited Publications
Target:
Research Areas:
Cisd2 agonist 2 (compound 6) is a Cisd2 activator (EC50=191 nM), and Cisd2 levels are associated with non-alcoholic fatty liver disease (NAFLD). Cisd2 agonist 2 has no significant in vivo toxicity in Cisd2hKO-het mice (heterozygous hepatocyte-specific Cisd2 knockout). Cisd2 (CDGSH iron sulfur domain 2) is a zinc finger protein that is mainly localized in the endoplasmic reticulum or mitochondrial membrane. Cisd2 participates in mitochondrial function by forming homodimers containing two redox-active 2Fe-2S clusters .
1
1 Cited Publications
Cat. No.: HY-P70039
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTCF; CFAP108; CCCTC-Binding Factor; FAP108; Transcriptional Repressor CTCF; CCCTC-Binding Factor (zinc finger Protein); 11-zinc finger Protein; 11 zinc finger Transcriptional Repressor; CTCFL Paralog; MRD21
1
1 Cited Publications
Cat. No.: HY-P70310
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: EGR1; TIS8; Early Growth Response 1; Transcription Factor Zif268; NGFI-A; zinc finger Protein Krox-24; AT225; zinc finger Protein 225; Nerve Growth Factor-Induced Protein A; zinc finger Gene 225; Early Growth Response Protein 1; ZNF225; Transcription Fact
1
1 Cited Publications
Cat. No.: HY-P86929
Synonyms: Histone acetyltransferase KAT6A EC:2.3.1.48 MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3 (MYST-3) Monocytic leukemia zinc finger protein Runt-related transcription factor-binding protein 2 zinc finger protein 220 KAT6A MOZ MYST3 RUNXBP2 Histone acetyltransferase KAT6A EC:2.3.1.48 MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3 (MYST-3) Monocytic leukemia zinc finger protein Runt-related transcription factor-binding protein 2 zinc finger protein 220 KAT6A MOZ MYST3 RUNXBP2 ZNF220
1
1 Cited Publications
Cat. No.: HY-P76262
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CISD1; CDGSH Iron-Sulfur Domain-Containing Protein 1; Prev. C10orf70; Chromosome 10 Open Reading Frame 70; Prev. ZCD1; zinc finger, CDGSH-Type Domain 1; MitoNEET; zinc finger CDGSH-Type Domain 1; MDS029; CDGSH Iron Sulfur Domain 1; Cysteine Transaminase C
1
1 Cited Publications
Cat. No.: HY-P702076
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: RBCK1; Hepatitis B Virus X-Associated Protein 4; Prev. C20orf18; RING finger Protein 54; UBCE7IP3; HOIL-1; RNF54; XAP3; XAP4; CDNA FLJ60704, Highly Similar To RanBP-Type And C3HC4-Type zincfinger-Containing Protein 1; RanBP-Type And C3HC4-Type zinc finger
1
1 Cited Publications
Cat. No.: HY-P81125
Synonyms: MGC126598 antibody;
Osterix antibody;
Osx antibody;
Sp 7 antibody;
SP7 antibody;
Sp7 transcription factor antibody;
SP7_HUMAN antibody;
Transcription factor Sp7 antibody;
zinc finger protein osterix antibody;
1
1
1 Cited Publications
Cat. No.: HY-P76079
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SMYD2; Histone Methyltransferase SMYD2; SET And MYND Domain Containing 2; ZMYND14; HSKM-B; Lysine N-Methyltransferase 3C; KMT3C; [Histone H3]-Lysine(4) N-Trimethyltransferase; SET And MYND Domain-Containing Protein 2; zinc finger, MYND Domain Containing 1
Species:
Source:
Cat. No.: HY-160695
CAS No.: 2924858-25-1
Target:
Research Areas:
PT-179 is an orthogonal Thalidomide (HY-14658) derivative that targets cereblon without causing off-target degradation effects. PT-179 is able to specifically bind CRBN, form a ternary complex with a target protein fused to a zinc finger (ZF) degron, and mediate the degradation of the tagged protein. For example, PT-179 binds to the ubiquitin ligase substrate receptor cereblon by forming a complex with SD40 and efficiently degrades proteins N- or C-terminally fused to SD40 or SD36 (DC50 for eGFP: 4.5 nM and 14.3 nM). PT-179 can be used to develop compact protein degradation tagging platforms .
Target:
Research Areas:
ALV2 is a potent and selective Helios molecular glue degrader. ALV2 binds CRBN, with an IC50 of 0.57 μM. Helios is the zinc-finger transcription factor that can maintain a stable Treg cell phenotype in the inflammatory tumor microenvironment .
Research Areas:
FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α). FPFT-2216 can be used for the research of cancer and inflammatory disease .
Cat. No.: HY-159647A
CAS No.: 2892065-49-3
Target:
Research Areas:
(S,S)-PLX-4545 (Compound I) is an orally active and cereblon-based molecular glue degrader of IKZF2 (zinc finger transcription factor Helios). (S,S)-PLX-4545 can be used for the study of IKZF2-mediated diseases or disorders, such as proliferative diseases or disorders and/or cancer .
Cat. No.: HY-159647B
CAS No.: 2892066-42-9
Target:
Research Areas:
(1S,2S,3R)-PLX-4545 is the (1S,2S,3R) enantiomer of PLX-4545 (HY-159647). PLX-4545 is an orally active and selective cereblon-based molecular glue degrader of IKZF2 (zinc finger transcription factor Helios). PLX-4545 can reprogram immunosuppressive regulatory T cells into pro-inflammatory effector T cells, thereby enhancing anti-tumor immune responses .
Cat. No.: HY-N0153R
CAS No.: 10236-47-2
Synonyms: Naringoside (Standard)
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
