1. GPCR/G Protein
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. Sigma Receptor
    Potassium Channel
  3. Sigma-1 receptor antagonist 3

Sigma-1 receptor antagonist 3 

Cat. No.: HY-125820
Handling Instructions

Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM. Sigma-1 receptor antagonist 3 inhibits Human Ether-a-go-go-Related Gene (hERG) with an IC50 of 1.54 μM. Sigma-1 receptor antagonist 3 is for treating neuropathic pain.

For research use only. We do not sell to patients.

Sigma-1 receptor antagonist 3 Chemical Structure

Sigma-1 receptor antagonist 3 Chemical Structure

CAS No. : 1639220-17-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 784 In-stock
Estimated Time of Arrival: December 31
1 mg USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 980 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM. Sigma-1 receptor antagonist 3 inhibits Human Ether-a-go-go-Related Gene (hERG) with an IC50 of 1.54 μM. Sigma-1 receptor antagonist 3 is for treating neuropathic pain[1].

IC50 & Target

IC50: 1.54μM (hERG)[1].
Ki : 1.14 nM (Sigma-1 receptor); 1239 nM (Sigma-2 receptor) [1]

Molecular Weight

363.86

Formula

C₁₉H₂₃ClFN₃O

CAS No.

1639220-17-9

SMILES

CC1=NC(C2=CC=C(F)C=C2)=NC(OCCCN3CCCCC3)=C1Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (34.35 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7483 mL 13.7415 mL 27.4831 mL
5 mM 0.5497 mL 2.7483 mL 5.4966 mL
10 mM 0.2748 mL 1.3742 mL 2.7483 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (3.44 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Sigma-1 receptor antagonist 3Sigma ReceptorPotassium ChannelKcsAInhibitorinhibitorinhibit

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Product name:
Sigma-1 receptor antagonist 3
Cat. No.:
HY-125820
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