SJF620 hydrochloride 

SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC₅₀ of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN^[1].

SJF620 hydrochloride is a PROTAC that retains potent degradation of BTK in cellular assays with a DC₅₀ of 7.9 nM in Burkitt lymphoma cell line NAMALWA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SJF620 hydrochloride has a super pharmacokinetic profile in mice (1 mg/kg; i.v.) with the half life (t_1/2) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

797.30

C₄₁H₄₅ClN₈O₇

2821938-05-8

Solid

White to off-white

O=C(N1)C(CCC1=O)N(C2=O)CC3=C2C=CC(OCCOCCOCCN4CCC(CC4)N5N=C(C6=C(N)N=CN=C65)C7=CC=C(C=C7)OC8=CC=CC=C8)=C3.[H]Cl

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.  [Content Brief]