2821938-05-8
2821938-05-8
Chemical Structure
SJF620 hydrochloride
- CAS No.: 2821938-05-8
- Formula:C41H45ClN8O7
- Molecular Weight:797.30
IUPAC Name: 3-(5-(2-(2-(2-(4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethoxy)ethoxy)ethoxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
InChIKey: RLEKBKXQGCJLQZ-UHFFFAOYSA-N
SMILES: O=C(N1)C(CCC1=O)N(C2=O)CC3=C2C=CC(OCCOCCOCCN4CCC(CC4)N5N=C(C6=C(N)N=CN=C65)C7=CC=C(C=C7)OC8=CC=CC=C8)=C3.Cl
Biological Activity: SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN[1].
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SJF620 hydrochloride | SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN. | |||||||||||||||||||||
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