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Cat. No.: HY-N21978

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Steppogenin 4'-O-β-D-glucoside

Steppogenin 4'-O-β-D-glucoside is a flavanone glycoside hypoglycemic agent that can be isolated from the root bark of Morus alba L. Steppogenin 4'-O-β-D-glucoside reduces the fasting blood glucose level of alloxan-induced diabetic mice. Steppogenin 4'-O-β-D-glucoside can be used in studies related to diabetes.

For research use only. We do not sell to patients.

CAS No.: 247031-40-9
Formula: C₂₁H₂₂O₁₁
Molecular Weight:450.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Steppogenin 4'-O-β-D-glucoside Chemical Structure

CAS No.: 247031-40-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vitro

Steppogenin 4'-O-β-D-glucoside (compound 2) is isolated from the root bark of Morus alba L. via silica gel and Sephadex LH-20 column chromatography, and identified by spectral analysis^[1].
Steppogenin 4'-O-β-D-glucoside (compound 6) is isolated from the ethanol extract of the stem bark of Maclura tinctoria (L.) Gaud., and is identified as a flavanone β-D-glucoside by MS, UV, NMR, acid hydrolysis and sugar analysis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Steppogenin 4'-O-β-D-glucoside (compound 2) (50, 100 mg/kg; p.o.; 3 days) reduces the fasting blood glucose level in alloxan-induced diabetic male ICR mice; the fasting blood glucose levels of the 50 and 100 mg/kg groups are 16.34 and 18.33 mmol/L, respectively, while that of the model group is 23.58 mmol/L^[1].
Steppogenin 4'-O-β-D-glucoside (compound 32) (50 mg/kg; p.o.) exhibits hypoglycemic activity in alloxan-induced diabetic mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR (male, weight 18-22 g, alloxan-induced diabetes mellitus)^[1]
Dosage:

50 mg/kg; 100 mg/kg
Administration:

p.o.; daily; 3 days
Result:

Reduced fasting blood glucose level of alloxan-diabetic mice to 16.34 mmol/L.
Reduced fasting blood glucose level of alloxan-diabetic mice to 18.33 mmol/L.

Chemical Information

CAS No. 247031-40-9
Molecular Weight 450.39
Formula C₂₁H₂₂O₁₁
SMILES

OC1=C2C(O[C@@H](CC2=O)C3=C(O)C=C(O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)C=C3)=CC(O)=C1
Structure Classification
- Flavonoids
- Flavonones
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang M, et al. In vivo hypoglycemic effects of phenolics from the root bark of Morus alba. Fitoterapia. 2009 Dec;80(8):475-7.

[2]. el-Sohly HN, et al. Flavonoids from Maclura tinctoria. Phytochemistry. 1999 Sep;52(1):141-5.

[3]. Hung HY, et al. Recent discovery of plant-derived anti-diabetic natural products. Natural product reports. 2012 May 01;29(5):580-606.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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