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Tauro-ω-muricholic acid sodium (Synonyms: TωMCA sodium)

Cat. No.: HY-136066
Handling Instructions

Tauro-ω-muricholic acid sodium (TωMCA sodium) is a bile acid released by the liver and an analog of tauro-α-muricholic acid. Tauro-ω-muricholic acid sodium is investigated as a potential marker in plasma for early-onset neonatal sepsis (EOS) and cholestasis studies

For research use only. We do not sell to patients.

Tauro-ω-muricholic acid sodium Chemical Structure

Tauro-ω-muricholic acid sodium Chemical Structure

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Description

Tauro-ω-muricholic acid sodium (TωMCA sodium) is a bile acid released by the liver and an analog of tauro-α-muricholic acid. Tauro-ω-muricholic acid sodium is investigated as a potential marker in plasma for early-onset neonatal sepsis (EOS) and cholestasis studies[1][2]

In Vivo

Sprague–Dawley rats are fed a standard diet with 1 week, and then randomly assigned to the two groups. The control group received a normal diet (10 kcal%), while the NAFLD group is fed a high-fat diet (60 kcal%; 18 weeks)[1].
10 BAs from the NAFLD group are significantly decreased in the liver, including 4 tauro-conjugated BA species including taurolithocholic acid (TLCA), THDCA, taurodeoxycholic acid (TDCA) and tauro ω-muricholic acid (TωMCA). Furthermore, βDCA, HDCA, 6-ketoLCA, 23-nordeoxycholic acid (NorDCA), LCA and 3β-chenodeoxycholic acid (βCDCA) shows lower levels in the NAFLD group[2].

Molecular Weight

537.68

Formula

C₂₆H₄₄NNaO₇S

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Tauro-ω-muricholic acidTωMCAOthersHFDEOSearly-onsetneonatalsepsisNAFLDbileacidBAInhibitorinhibitorinhibit

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Tauro-ω-muricholic acid sodium
Cat. No.:
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