Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium
Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) exhibits substantially longer t1/2 values than tenofovir in human liver microsomes, potent anti-HIV activity in vitro, and enhances pharmacokinetic properties in vivo. Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- CAS No.: 2611373-74-9
- Formula: C29H55N6O5PSi
- Molecular Weight:626.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | CC50 |
>100 μM
Compound: 23
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Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 48 hrs by CellTiter 96 Aqueous One Solution reagent based cell proliferation assay
Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 48 hrs by CellTiter 96 Aqueous One Solution reagent based cell proliferation assay
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[PMID: 34459598] |
Chemical Information
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CAS No. 2611373-74-9
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Molecular Weight 626.84
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Formula C29H55N6O5PSi
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SMILES
C[Si](C)(C)C#CCCCCCCCCCCCCOCCCOP(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)([O-])=O.[NH4+]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium Related Classifications
HY-139722 Related Classifications
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