2611373-74-9
Chemical Structure
Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium
- CAS No.: 2611373-74-9
- Formula:C29H55N6O5PSi
- Molecular Weight:626.84
IUPAC Name: ammonium 3-((14-(trimethylsilyl)tetradec-13-yn-1-yl)oxy)propyl (R)-(((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
InChIKey: VJLNQNZHVPHART-UFTMZEDQSA-N
SMILES: C[Si](C)(C)C#CCCCCCCCCCCCCOCCCOP(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)([O-])=O.[NH4+]
Biological Activity: Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) exhibits substantially longer t1/2 values than tenofovir in human liver microsomes, potent anti-HIV activity in vitro, and enhances pharmacokinetic properties in vivo. Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium | Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) exhibits substantially longer t1/2 values than tenofovir in human liver microsomes, potent anti-HIV activity in vitro, and enhances pharmacokinetic properties in vivo. Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | |||||||||||||||||||||
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