TG11-77 hydrochloride
TG11-77 hydrochloride is a potent, selective, orally active and brain permeant EP2 antagonist, with a KB of 9.7 nM. TG11-77 hydrochloride inhibits PGE2-induced human EP2 receptor activation. TG11-77 hydrochloride exhibits anti-inflammatory activity. TG11-77 hydrochloride reduces delayed mortality and memory deficit.
For research use only. We do not sell to patients.
- CAS No.: 2550393-38-7
- Formula: C23H25ClN6O
- Molecular Weight:436.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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EP2 9.7 nM (Kb) |
Chemical Information
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CAS No. 2550393-38-7
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Molecular Weight 436.94
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Formula C23H25ClN6O
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SMILES
O=C(C1=CN=C(NC2=CC(C)=CC(C)=N2)N=C1)NCCC3=C(C)NC4=C3C=CC=C4.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Amaradhi R, et al. Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist for Use in Central Nervous System Disease Models. J Med Chem. 2020 Feb 13;63(3):1032-1050. [Content Brief]
[2]. Varvel NH, et al. Preclinical development of an EP2 antagonist for post-seizure cognitive deficits. Neuropharmacology. 2023 Feb 15;224:109356. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TG11-77 hydrochloride Related Classifications
HY-158659 Related Classifications
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