Thalidomide-O-amido-PEG1-azide
Thalidomide-O-amido-PEG1-azide is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Thalidomide-O-amido-PEG1-azide can be linked to a target protein ligand via a linker to form a PROTAC.
For research use only. We do not sell to patients.
- CAS No.: 2597167-25-2
- Formula: C19H20N6O7
- Molecular Weight:444.40
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2597167-25-2
-
Molecular Weight 444.40
-
Formula C19H20N6O7
-
SMILES
[N-]=[N+]=NCCOCCNC(=O)COC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)