Thalidomide-O-PEG4-amine hydrochloride

Name: Thalidomide-O-PEG4-amine hydrochloride
Brand: MedChemExpress
SKU: HY-141010A
Rating: 4.5 (0 reviews)

製品番号: HY-141010A 純度: 95.24%: Data Sheet SDS COA 取扱説明書
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Thalidomide-O-PEG4-amine hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Thalidomide-O-PEG4-amine hydrochloride 構造式

CAS 番号 : 2820929-03-9

容量	価格（税別）	在庫状況	数量
Oil + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 371	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 371	在庫あり	Estimated Time of Arrival: December 31
Oil
50 mg	$338	在庫あり	Estimated Time of Arrival: December 31
100 mg	$540	在庫あり	Estimated Time of Arrival: December 31
250 mg	$960	在庫あり	Estimated Time of Arrival: December 31
500 mg		お問い合わせ
1 g		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Other Forms of Thalidomide-O-PEG4-amine hydrochloride:

Thalidomide-O-PEG4-amine お問い合わせ
Thalidomide-O-PEG4-amine TFA お問い合わせ

E3 Ligase Ligand-Linker Conjugates アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Thalidomide-O-PEG4-amine hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology^[1].

IC₅₀ & Target^[1]

Cereblon

体外実験

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

529.97

分子式

C₂₃H₃₂ClN₃O₉

CAS 番号

2820929-03-9

Appearance

Oil

Color

Colorless to yellow

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCOCCOCCOCCOCCN)=O.[H]Cl

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶剤 & 溶解度

体外:

DMSO : 250 mg/mL (471.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8869 mL	9.4345 mL	18.8690 mL
5 mM	0.3774 mL	1.8869 mL	3.7738 mL
10 mM	0.1887 mL	0.9434 mL	1.8869 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 95.24%

Select Batch:

データシート (268 KB) SDS (252 KB)

COA (244 KB) HNMR (277 KB) LCMS (89 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Zhang NN, et al. A Thermostable mRNA Vaccine against COVID-19. Cell. 2020;182(5):1271-1283.e16. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8869 mL	9.4345 mL	18.8690 mL	47.1725 mL
	5 mM	0.3774 mL	1.8869 mL	3.7738 mL	9.4345 mL
	10 mM	0.1887 mL	0.9434 mL	1.8869 mL	4.7172 mL
	15 mM	0.1258 mL	0.6290 mL	1.2579 mL	3.1448 mL
	20 mM	0.0943 mL	0.4717 mL	0.9434 mL	2.3586 mL
	25 mM	0.0755 mL	0.3774 mL	0.7548 mL	1.8869 mL
	30 mM	0.0629 mL	0.3145 mL	0.6290 mL	1.5724 mL
	40 mM	0.0472 mL	0.2359 mL	0.4717 mL	1.1793 mL
	50 mM	0.0377 mL	0.1887 mL	0.3774 mL	0.9434 mL
	60 mM	0.0314 mL	0.1572 mL	0.3145 mL	0.7862 mL
	80 mM	0.0236 mL	0.1179 mL	0.2359 mL	0.5897 mL
	100 mM	0.0189 mL	0.0943 mL	0.1887 mL	0.4717 mL