2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Trk Receptor
  4. TRK-IN-12

TRK-IN-12 (Compound 9e) is a potent inhibitor of TRK (TRKG595R IC50 = 13.1 nM). TRK-IN-12 is a macrocyclic derivative compound. TRK-IN-12 shows significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (IC50 = 0.080 μM). TRK-IN-12 has shown a better inhibitory effect (IC50 = 0.646 μM) than control agent LOXO-101 in Ba/F3-LMNA-NTRK1-G595R cell line.

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TRK-IN-12

TRK-IN-12 화학구조

CAS No. : 2823342-34-1

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TRK-IN-12 Related Antibodies

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제품 설명

TRK-IN-12 (Compound 9e) is a potent inhibitor of TRK (TRKG595R IC50 = 13.1 nM). TRK-IN-12 is a macrocyclic derivative compound. TRK-IN-12 shows significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (IC50 = 0.080 μM). TRK-IN-12 has shown a better inhibitory effect (IC50 = 0.646 μM) than control agent LOXO-101 in Ba/F3-LMNA-NTRK1-G595R cell line[1].

Cellular Effect
Cell Line Type Value Description References
BaF3 IC50
0.08 μM
Compound: 9e
Antiproliferative activity against mouse BaF3 cells harboring LMNA fused NTRKA1
Antiproliferative activity against mouse BaF3 cells harboring LMNA fused NTRKA1
[PMID: 34628036]
BaF3 IC50
0.646 μM
Compound: 9e
Antiproliferative activity against mouse BaF3 cells harboring LMNA fused NTRKA1 G595R mutant
Antiproliferative activity against mouse BaF3 cells harboring LMNA fused NTRKA1 G595R mutant
[PMID: 34628036]
분자량

439.89

화학식

C18H19ClFN5O3S
CAS No.
SMILES

CN1CC2=CC(F)=CC=C2OCCN(CC3=C4N=C1C=CN4N=C3)S(=O)(CCl)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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TRK-IN-12 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRK-IN-122823342-34-1Trk ReceptorTropomyosin related kinase receptorTRKmacrocyclic derivativeantiproliferativeInhibitorinhibitorinhibit

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상품명:
TRK-IN-12
Cat. No.:
HY-144451
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