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Tryptamine guanosine carbamate (Synonyms: TpGc)

Cat. No.: HY-138885
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Tryptamine guanosine carbamate (TpGc) is a selective HINT1 (histidine triad nucleotide-binding protein 1) inhibitor (Ki=34 μM, Kd=3.65 μM). Tryptamine guanosine carbamate significantly enhances morphine antinociception while preventing the development of tolerance.

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Tryptamine guanosine carbamate Chemical Structure

Tryptamine guanosine carbamate Chemical Structure

CAS No. : 1414808-96-0

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Description

Tryptamine guanosine carbamate (TpGc) is a selective HINT1 (histidine triad nucleotide-binding protein 1) inhibitor (Ki=34 μM, Kd=3.65 μM). Tryptamine guanosine carbamate significantly enhances morphine antinociception while preventing the development of tolerance[1].

In Vivo

Pretreatment with 20 nmol TpGc enhanced morphine antinociception in 129 HINT1+/+ mice and is devoid of effect in HINT1-/- mice.The administration of 7 and 20 nmol of TpGc 20min before the morphine priming dose significantly reduces the development of acute antinociceptive tolerance in HINT1+/+ mice but not in HINT1-/- animals[1].
TpGc reduces the recruitment of NMDAR activity promoted by morphine. In mice suffering from chronic constriction injury concurrent with increased NMDAR activity, a single intracerebroventricular administration of TpGc (20 nmol) attenuates NMDAR function and alleviated mechanical allodynia for several days[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

469.45

Formula

C₂₁H₂₃N₇O₆

CAS No.
SMILES

O[[email protected]]1[[email protected]](O[[email protected]@H]([[email protected]]1O)COC(NCCC2=CNC3=CC=CC=C23)=O)([H])N4C5=C(C(N=C(N5)N)=O)N=C4

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Tryptamine guanosine carbamateTpGcOthersantinociceptionchronicconstrictioninjurymechanicalallodyniaInhibitorinhibitorinhibit

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Tryptamine guanosine carbamate
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