Tryptamine guanosine carbamate
Based on 1 Customer Validation
Tryptamine guanosine carbamate (TpGc) is a selective HINT1 (histidine triad nucleotide-binding protein 1) inhibitor (Ki=34 μM, Kd=3.65 μM). Tryptamine guanosine carbamate significantly enhances morphine antinociception while preventing the development of tolerance.
For research use only. We do not sell to patients.
- Purity: 99.79%
- CAS No.: 1414808-96-0
- Formula: C21H23N7O6
- Molecular Weight:469.45
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
Tryptamine guanosine carbamate reduces the recruitment of NMDAR activity promoted by morphine. In mice suffering from chronic constriction injury concurrent with increased NMDAR activity, a single intracerebroventricular administration of Tryptamine guanosine carbamate (20 nmol) attenuates NMDAR function and alleviated mechanical allodynia for several days[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1414808-96-0
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Appearance Solid
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Molecular Weight 469.45
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Formula C21H23N7O6
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Color White to off-white
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C3=C(C(N=C(N3)N)=O)N=C2)O[C@@H]1COC(NCCC4=CNC5=CC=CC=C45)=O
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Synonyms
TpGc
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 125 mg/mL (266.27 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1302 mL | 10.6508 mL | 21.3015 mL | 53.2538 mL |
| 5 mM | 0.4260 mL | 2.1302 mL | 4.2603 mL | 10.6508 mL | |
| 10 mM | 0.2130 mL | 1.0651 mL | 2.1302 mL | 5.3254 mL | |
| 15 mM | 0.1420 mL | 0.7101 mL | 1.4201 mL | 3.5503 mL | |
| 20 mM | 0.1065 mL | 0.5325 mL | 1.0651 mL | 2.6627 mL | |
| 25 mM | 0.0852 mL | 0.4260 mL | 0.8521 mL | 2.1302 mL | |
| 30 mM | 0.0710 mL | 0.3550 mL | 0.7101 mL | 1.7751 mL | |
| 40 mM | 0.0533 mL | 0.2663 mL | 0.5325 mL | 1.3313 mL | |
| 50 mM | 0.0426 mL | 0.2130 mL | 0.4260 mL | 1.0651 mL | |
| 60 mM | 0.0355 mL | 0.1775 mL | 0.3550 mL | 0.8876 mL | |
| 80 mM | 0.0266 mL | 0.1331 mL | 0.2663 mL | 0.6657 mL | |
| 100 mM | 0.0213 mL | 0.1065 mL | 0.2130 mL | 0.5325 mL |
Tryptamine guanosine carbamate Related Classifications
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