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Cat. No.: HY-175565

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Tubulin/VEGFR-2-IN-1

Tubulin/VEGFR-2-IN-1 is a dual inhibitor of tubulin and VEGFR-2 (IC₅₀ = 1.52 μM) with anti-angiogenic activity. Tubulin/VEGFR-2-IN-1 exhibits potent cytotoxicity against the cancer cells. Tubulin/VEGFR-2-IN-1 elevates ROS production, induces apoptosis and causes G0/G1 phase arrest in HepG-2 cells. Tubulin/VEGFR-2-IN-1 inhibits the migratory ability and the clonogenic ability in HepG-2 cells. Tubulin/VEGFR-2-IN-1 can be used for the study of cancer.

For research use only. We do not sell to patients.

Formula: C₂₉H₂₈BrN₃O₃
Molecular Weight:546.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Tubulin/VEGFR-2-IN-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

VEGFR-2

1.52 μM (IC₅₀)

All VEGFR Isoforms :

In Vitro

Tubulin/VEGFR-2-IN-1 (Compound 8u) (48 h) exhibits potent cytotoxicity against multiple cancer cell lines, with IC₅₀ values of 1.88 μM for HepG-2, 14.76 μM for A549, 16.47 μM for MCF-7, and 15.47 μM for HCT-116 cells^[1].
Tubulin/VEGFR-2-IN-1 (0.94-3.76 μM, 48 h) elevates ROS production, induces apoptosis and causes G0/G1 phase arrest in HepG-2 cells^[1].
Tubulin/VEGFR-2-IN-1 (0.94-3.76 μM, 48 h) inhibits the migratory ability and the clonogenic ability of HepG-2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

HepG-2 cells
Concentration:

0.94, 1.88, 3.76 μM
Incubation Time:

48 h
Result:

Showed a concentration-dependent increase in apoptotic cell populations.

Cell Cycle Analysis^[1]

Cell Line:

HepG-2 cells
Concentration:

0.94, 1.88, 3.76 μM
Incubation Time:

48 h
Result:

Caused G0/G1 phase arrest in HepG-2 cells in a dose-dependent manner.

Cell Migration Assay ^[1]

Cell Line:

HepG-2 cells
Concentration:

0.94, 1.88, 3.76 μM
Incubation Time:

48 h
Result:

Inhibited the migration of HepG-2 cells.

Chemical Information

Molecular Weight 546.45
Formula C₂₉H₂₈BrN₃O₃
SMILES

O=C([C@]12[C@H](C(N3CCN(CC4=CC=CC=C4)CC3)=O)[C@H]1C5=CC=C(OC)C=C5)NC6=C2C=C(Br)C=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dastari S, et al. Design, synthesis and biological evaluation of spirocyclopropyl oxindole-piperazine/morpholine-based carboxamides as potential anticancer agents. Bioorg Chem. 2025 Aug;163:108784. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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