DOTA-NHS-ester TFA
Based on 1 publication(s) in Google Scholar
DOTA-NHS-ester (TFA) is used as a linker for affibody molecules, and it can be employed in small animal positron emission tomography (PET), single photon emission computed tomography (SPECT), and CT scanning. DOTA-NHS-ester can be used to label radiotracers or imaging probes for tumor detection.
For research use only. We do not sell to patients.
- Purity: 95.0%
- Formula: C22H32F3N5O12
- Molecular Weight:615.51
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) DOTA-NHS-ester TFA
More
Customer Validation & Images
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In Vivo Efficacy Study
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In Vivo Efficacy Study
Biological Activity
Chemical Information
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Appearance Solid
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Molecular Weight 615.51
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Formula C22H32F3N5O12
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Color White to off-white
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SMILES
OC(C(F)(F)F)=O.O=C(ON1C(CCC1=O)=O)CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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DOTA-NHS-ester TFA purchased from MedChemExpress. Usage Cited in: Adv Nanobiomed Res. 2023 Sep 3.
PSP–NH2 was incubated with DOTA–NHS–ester for 1 h and conjugated with mPEG–NHS. Then, the particles were mixed with 64Cu (OAc)2 at 50 ℃ for 1 h to obtain the 64Cu-labelled PSP. PSP@Ab@PEG exhibited increased blood circulation in BALB/c mice with blood clearance half-life periods found to be 12 min.
DOTA-NHS-ester TFA purchased from MedChemExpress. Usage Cited in: Adv Nanobiomed Res. 2023 Sep 3.
PSP–NH2 was incubated with DOTA–NHS–ester for 1 h and conjugated with mPEG–NHS. Then, the particles were mixed with 64Cu (OAc)2 at 50 ℃ for 1 h to obtain the 64Cu-labelled PSP. More PSP–NH2 accumulated in the liver site while a lot more PSP@Ab@PEG accumulated in the spleen.
Solvent & Solubility
DMSO : 125 mg/mL (203.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6247 mL | 8.1233 mL | 16.2467 mL | 40.6167 mL |
| 5 mM | 0.3249 mL | 1.6247 mL | 3.2493 mL | 8.1233 mL | |
| 10 mM | 0.1625 mL | 0.8123 mL | 1.6247 mL | 4.0617 mL | |
| 15 mM | 0.1083 mL | 0.5416 mL | 1.0831 mL | 2.7078 mL | |
| 20 mM | 0.0812 mL | 0.4062 mL | 0.8123 mL | 2.0308 mL | |
| 25 mM | 0.0650 mL | 0.3249 mL | 0.6499 mL | 1.6247 mL | |
| 30 mM | 0.0542 mL | 0.2708 mL | 0.5416 mL | 1.3539 mL | |
| 40 mM | 0.0406 mL | 0.2031 mL | 0.4062 mL | 1.0154 mL | |
| 50 mM | 0.0325 mL | 0.1625 mL | 0.3249 mL | 0.8123 mL | |
| 60 mM | 0.0271 mL | 0.1354 mL | 0.2708 mL | 0.6769 mL | |
| 80 mM | 0.0203 mL | 0.1015 mL | 0.2031 mL | 0.5077 mL | |
| 100 mM | 0.0162 mL | 0.0812 mL | 0.1625 mL | 0.4062 mL |
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