Lta4h - leukotriene A4 hydrolase Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16993

Summary

The protein encoded by this gene is an enzyme that contains both hydrolase and Aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The Aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Lta4h Products (2)

mRNA Protein Name
NM_001313897.1 NP_001300826.1 leukotriene A-4 hydrolase isoform 2
NM_008517.2 NP_032543.2 leukotriene A-4 hydrolase isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23055941 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leukotriene A-4 hydrolase

  • LTA-4 hydrolase

  • LTA4 hydrodase

  • tripeptide aminopeptidase LTA4H

Recombinant Lta4h Proteins

Cat. No. Product Name Accession Purity
HY-P74776 Leukotriene A4 Hydrolase/LTA4H Protein, Mouse (sf9, His) P24527 (M1-D611) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-10825 DG051 Inhibitor 99.86% Phase 2
HY-137298A LYS006 hydrochloride Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-137298 LYS006 Inhibitor 98.41% Unkown
HY-103226 SC-57461A Inhibitor 99.93% Unkown
HY-162710 LTA4H-IN-5 Inhibitor / Unkown
HY-10828 SC-57461 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lta4h NCBI NCBI:4048