LTA4H - leukotriene A4 hydrolase Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4048

About LTA4H

Cytogenetic location: 12q23.1 Genomic coordinates (GRCh38): 12:96,000,753-96,043,520 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues and 11 paralogues. Ubiquitous expression in lung (RPKM 63.8), bone marrow (RPKM 53.7) and 25 other tissues.

Summary

The protein encoded by this gene is an enzyme that contains both hydrolase and Aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The Aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

LTA4H Products (7)

mRNA Protein Name
NM_000895.3 NP_000886.1 leukotriene A-4 hydrolase isoform 1
NM_001256643.1 NP_001243572.1 leukotriene A-4 hydrolase isoform 2
NM_001256644.1 NP_001243573.1 leukotriene A-4 hydrolase isoform 3
NM_001414263.1 NP_001401192.1 leukotriene A-4 hydrolase isoform 4
NM_001414264.1 NP_001401193.1 leukotriene A-4 hydrolase isoform 5
NM_001414265.1 NP_001401194.1 leukotriene A-4 hydrolase isoform 6
NM_001414266.1 NP_001401195.1 leukotriene A-4 hydrolase isoform 7

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables aminopeptidase activity IDA
IDA: Inferred from direct assay
9774412 GOA
enables epoxide hydrolase activity IDA
IDA: Inferred from direct assay
15078870 GOA
enables epoxide hydrolase activity IMP
IMP: Inferred from mutant phenotype
11675384 GOA
enables leukotriene-A4 hydrolase activity IDA
IDA: Inferred from direct assay
9774412 GOA
enables metalloaminopeptidase activity IMP
IMP: Inferred from mutant phenotype
11675384 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
15078870 GOA
enables zinc ion binding IMP
IMP: Inferred from mutant phenotype
11675384 GOA
Biological Process GO Annotation Evidence References Source
involved in leukotriene biosynthetic process IDA
IDA: Inferred from direct assay
9774412 GOA
involved in leukotriene biosynthetic process IMP
IMP: Inferred from mutant phenotype
11675384 GOA
involved in peptide catabolic process IDA
IDA: Inferred from direct assay
9774412 GOA
involved in protein metabolic process IMP
IMP: Inferred from mutant phenotype
11675384 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LTA4H Protein Structure

Peptidase_M1

Peptidase_M1: Peptidase family M1 domain (19 - 387)

Leuk-A4-hydro_C

Leuk-A4-hydro_C: Leukotriene A4 hydrolase, C-terminal (464 - 608)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 611 a.a.
Protein Preferred Names Protein Names

leukotriene A-4 hydrolase

  • LTA-4 hydrolase

LTA4H Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LTA4H P09960 TINF2 Homo sapiens Q9BSI4
Pull Down
21044950
Intra
LTA4H P09960 TINF2 Homo sapiens Q9BSI4
BiFC
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LTA4H Proteins

Cat. No. Product Name Accession Purity
HY-P70277 Leukotriene A4 Hydrolase/LTA4H Protein, Human (HEK293, His) P09960-1 (M1-D611) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73275 Leukotriene A4 Hydrolase/LTA4H Protein, Human (sf9, His) P09960-1/NP_000886.1 (M1-D611) ≥ 95%, as determined by reducing SDS-PAGE.

LTA4H Antibodies

Cat. No. Product Name Application Reactivity
HY-P82655 Leukotriene A4 Hydrolase Antibody (YA2400) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Soft Palate Cancer

  • Malignant Tumor Of Soft Palate

  • Malignant Tumor Of The Soft Palate

  • Palate Cancer Soft Palate
Lymph Node Tuberculosis

  • King'S Evil

  • Scrofula

  • Tuberculous Adenitis

  • Tuberculous Lymphadenopathy

  • Tuberculosis, Lymph Node
Psoriasis
Myocardial Infarction

  • Heart Attack

  • Myocardial Infarction, Susceptibility To

  • Myocardial Infarction 1

  • Myocardial Infarction, Protection Against

  • Myocardial Infarction, Decreased Susceptibility To

  • Myocardial Infarction, Decreased

  • Myocardial Infarct

  • MCI1

  • Premature Myocardial Infarction

  • Myocardial Infarction, Susceptibility To, Type 1
Leprosy 3

  • Leprosy

  • Leprosy, Susceptibility To, 3

  • Hansen'S Disease

  • Leprosy, Susceptibility To

  • Hansen Disease

  • Infection Due To Mycobacterium Leprae

  • LPRS3

  • Leprosy, Type 3

  • Anaesthesia Leprosy

  • Anaesthetic Leprosy

  • Maculoanaesthetic Leprosy

  • Macular Leprosy

  • Leprosy Unspecified
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-10825 DG051 Inhibitor 99.86% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-137298 LYS006 Inhibitor 98.41% Unkown
HY-103226 SC-57461A Inhibitor 99.93% Unkown
HY-162710 LTA4H-IN-5 Inhibitor / Unkown
HY-10828 SC-57461 Inhibitor / Unkown
HY-137298A LYS006 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LTA4H VGNC VGNC:68100
Canis familiaris LTA4H VGNC VGNC:42853
Rattus norvegicus LTA4H RGD RGD:1311333
Macaca mulatta LTA4H VGNC VGNC:74453
Mus musculus LTA4H MGD MGI:96836
Bos taurus LTA4H VGNC VGNC:31067
Others LTA4H NCBI