LTA4H - leukotriene A4 hydrolase Gene

Homo sapiens

Gene ID: 4048 | Gene type: protein coding

About LTA4H

Cytogenetic location: 12q23.1 Genomic coordinates (GRCh38): 12:96,000,753-96,043,520 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues and 11 paralogues. Ubiquitous expression in lung (RPKM 63.8), bone marrow (RPKM 53.7) and 25 other tissues.

Summary

The protein encoded by this gene is an Enzyme that contains both hydrolase and Aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The Aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

LTA4H Products(7)

mRNA	Protein	Name
NM_000895.3	NP_000886.1	leukotriene A-4 hydrolase isoform 1
NM_001256643.1	NP_001243572.1	leukotriene A-4 hydrolase isoform 2
NM_001256644.1	NP_001243573.1	leukotriene A-4 hydrolase isoform 3
NM_001414263.1	NP_001401192.1	leukotriene A-4 hydrolase isoform 4
NM_001414264.1	NP_001401193.1	leukotriene A-4 hydrolase isoform 5
NM_001414265.1	NP_001401194.1	leukotriene A-4 hydrolase isoform 6
NM_001414266.1	NP_001401195.1	leukotriene A-4 hydrolase isoform 7

LTA4H Protein Structure

Peptidase_M1

Leuk-A4-hydro_C

0
100
200
300
400
500
611 a.a.

Protein Preferred Names

Protein Names

leukotriene A-4 hydrolase

LTA-4 hydrolase

Recombinant LTA4H Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70277	Leukotriene A4 Hydrolase/LTA4H Protein, Human (HEK293, His)	P09960 (M1-D611)	≥95%
HY-P73275	Leukotriene A4 Hydrolase/LTA4H Protein, Human (sf9, His)	P09960 (M1-D611)	≥95%

Related Diseases

Diseases

Alias

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Soft Palate Cancer

Malignant Tumor Of Soft Palate	Malignant Tumor Of The Soft Palate
Palate Cancer Soft Palate

Lymph Node Tuberculosis

King'S Evil	Scrofula
Tuberculous Adenitis	Tuberculous Lymphadenopathy
Tuberculosis, Lymph Node

Psoriasis

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Leprosy 3

Leprosy	Leprosy, Susceptibility To, 3
Hansen'S Disease	Leprosy, Susceptibility To
Hansen Disease	Infection Due To Mycobacterium Leprae
LPRS3	Leprosy, Type 3
Anaesthesia Leprosy	Anaesthetic Leprosy
Maculoanaesthetic Leprosy	Macular Leprosy
Leprosy Unspecified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0494	Bufexamac	Inhibitor	≥98.0%	Unkown

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137298	LTA4H-IN-1	Inhibitor	98.61%	Unkown
HY-W027340	ARM1	Inhibitor	99.32%	Unkown
HY-W004291	Methyl arachidate	Inhibitor	≥98.0%	Unkown
HY-156960	JNJ-40929837	Inhibitor	/	Unkown
HY-156960A	JNJ-40929837 succinate	Inhibitor	/	Unkown
HY-160646	LTA4H-IN-3	Inhibitor	/	Unkown
HY-161349	LTA4H-IN-4	Inhibitor	/	Unkown
HY-N8760	Batatasin IV	Inhibitor	/	Unkown
HY-RS07871	LTA4H Human Pre-designed siRNA Set A		/	Unkown
HY-W004291R	Methyl arachidate (Standard)	Inhibitor	/	Unkown
HY-162015	LTA4H-IN-2	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LTA4H	VGNC	VGNC:68100
Canis familiaris	LTA4H	VGNC	VGNC:42853
Rattus norvegicus	LTA4H	RGD	RGD:1311333
Macaca mulatta	LTA4H	VGNC	VGNC:74453
Mus musculus	LTA4H	MGD	MGI:96836
Bos taurus	LTA4H	VGNC	VGNC:31067
Others	LTA4H	NCBI

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