2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. (Z)-Tyrphostin A51

(Z)-Tyrphostin A51 is the Z configuration of Lanoconazole A51. Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [3H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation.

Para uso exclusivo en investigación. No vendemos a pacientes.

(Z)-Tyrphostin A51

(Z)-Tyrphostin A51 Estructura química

No. CAS : 122520-90-5

Tamaño Precio Stock Cantidad
5 mg Obtener un presupuesto 3 - 4 Weeks 4 - 5 weeks 5 - 6 weeks 2 - 3 weeks
10 mg   Obtener un presupuesto  
50 mg   Obtener un presupuesto  
Synthetic products have potential research and development risk.

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 Customer Validation

Other Forms of (Z)-Tyrphostin A51:

(Z)-Tyrphostin A51 Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas EGFR:

Ver todas las isoformas
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

(Z)-Tyrphostin A51 is the Z configuration of Lanoconazole A51. Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [3H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation[1][2].

Cellular Effect
Cell Line Type Value Description References
A-431 IC50
8 × 10-1μM
Compound: 120
Inhibition of EGFR in human A431 cells
Inhibition of EGFR in human A431 cells
[PMID: 1479375]
Peso molecular

268.23

Fòrmula

C13H8N4O3
No. CAS
SMILES

N#C/C(C#N)=C(N)/C(C#N)=C/C1=CC(O)=C(O)C(O)=C1.[(Z)]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvente y solubilidad
In Vitro: 

DMSO : 20 mg/mL (74.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7281 mL 18.6407 mL 37.2814 mL
5 mM 0.7456 mL 3.7281 mL 7.4563 mL
View the Complete Stock Solution Preparation Table

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7281 mL 18.6407 mL 37.2814 mL 93.2036 mL
5 mM 0.7456 mL 3.7281 mL 7.4563 mL 18.6407 mL
10 mM 0.3728 mL 1.8641 mL 3.7281 mL 9.3204 mL
15 mM 0.2485 mL 1.2427 mL 2.4854 mL 6.2136 mL
20 mM 0.1864 mL 0.9320 mL 1.8641 mL 4.6602 mL
25 mM 0.1491 mL 0.7456 mL 1.4913 mL 3.7281 mL
30 mM 0.1243 mL 0.6214 mL 1.2427 mL 3.1068 mL
40 mM 0.0932 mL 0.4660 mL 0.9320 mL 2.3301 mL
50 mM 0.0746 mL 0.3728 mL 0.7456 mL 1.8641 mL
60 mM 0.0621 mL 0.3107 mL 0.6214 mL 1.5534 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

(Z)-Tyrphostin A51 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Z)-Tyrphostin A51122520-90-5(Z)-AG-183EGFREpidermal growth factor receptorErbB-1HER1aspartatetaurineastrocyte cultureshuman bone celltyrosyl phosphorylationInhibitorinhibitorinhibit

Productos vistos recientemente:

Consulta en línea

Your information is safe with us. * Required Fields.

Nombre del producto

  

Requested Quantity *

Nombre del solicitante *

 

Saludo

Direcciòn del E-mail *

 

Número de teléfono *

Department

 

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

      

Observaciones

Consulta para venta a granel

Inquiry Information

Nombre del producto:
(Z)-Tyrphostin A51
Cat. No.:
HY-101960
Cantidad:
MCE Japan Authorized Agent:

Revisión del cliente

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nombre del producto

  

Lot #

Nombre del solicitante *

 

Direcciòn del E-mail *

Número de teléfono

 

Department *

Nombre de la Organizaciòn *

 

Country or Region *

Observaciones

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.