α-Androstenol
Based on 1 Customer Validation
α-Androstenol (5α-Androst-16-en-3α-ol) is a steroid pheromone that has been found in boar testes and male axillary sweat. α-Androstenol is also a positive allosteric modulator of GABAA receptors, which enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50 of 0.4 μM). α-Androstenol produces anxiolytic-like, antidepressant-like, and anticonvulsant effects in mice. α-Androstenol can be used for the research of seizures.
For research use only. We do not sell to patients.
- Purity: 99.85%
- CAS No.: 1153-51-1
- Formula: C19H30O
- Molecular Weight:274.44
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
0.2 μM
Compound: Androstenol
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Cytotoxicity against HEK293 cells
Cytotoxicity against HEK293 cells
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[PMID: 18973326] |
α-Androstenol potently and stereoselectively enhances GABA-activated currents in primary cultured mouse cerebellar granule cells (DIV 7) with an EC50 of 0.382 μM[1].
α-Androstenol enhances GABA-activated currents in granule cells from mouse cerebellar slices (postnatal day 11-12) with an EC50 of 1.4 μM[1].
α-Androstenol (0.1-1 μM; 15-20 s preapplication, coapplied with GABA) potentiates GABA-activated currents in HEK 293 cells expressing recombinant α1β2γ2 or α2β2γ2 GABAA receptors in a concentration-dependent manner[1].
α-Androstenol (1-300 μM) directly activates α1β2γ2 GABAA receptors in HEK 293 cells, with maximal responses equivalent to ~30% of the 5 μM GABA response[1].
α-Androstenol (0.1 μM) prolongs the decay of spontaneous inhibitory postsynaptic currents in primary cultured mouse cerebellar granule cells (DIV 7) without altering peak amplitude[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
α-Androstenol (100-300 mg/kg; i.p.; single injection) causes motor impairment in the mouse horizontal screen test with a TD50 of 181 mg/kg[1].
α-Androstenol (5-30 mg/kg; i.p.; single injection) produces antidepressant-like effects in the mouse forced swim test at doses of 5 and 10 mg/kg, as measured by reduced immobility time, while the 30 mg/kg dose is inactive[1].
α-Androstenol (10-100 mg/kg; i.p.; single injection) protects against seizures in the mouse 6-Hz electroshock model with an ED50 of 21.9 mg/kg[1].
α-Androstenol (10-100 mg/kg; i.p.; single injection) protects against pentylenetetrazol-induced seizures in mice with an ED50 of 48.9 mg/kg[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NIH Swiss (male, 25-30 g)[1]
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Dosage:10 mg/kg; 30 mg/kg; 50 mg/kg
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Administration:i.p.; single injection
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Result:Produced significant increases in the area-under-the-curve values for percentage time spent in the center of the arena.
Increased the fraction of time spent in the center of the arena in a dose-dependent fashion.\nCaused a dose-dependent reduction in latency to first open-arm entry.
Caused a dose-dependent increase in the number of open-arm entries.
Caused a dose-dependent increase in percentage time spent in open arms, with significant effect observed at 50 mg/kg.
Chemical Information
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CAS No. 1153-51-1
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Appearance Solid
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Molecular Weight 274.44
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Formula C19H30O
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Color White to off-white
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SMILES
[H][C@@]12CC=C[C@]1(CC[C@]3([C@]2(CC[C@]4(C[C@@H](CC[C@]34C)O)[H])[H])[H])C
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Synonyms
5α-Androst-16-en-3α-ol
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 4.17 mg/mL (15.19 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Kaminski RM, et al. The pheromone androstenol (5 alpha-androst-16-en-3 alpha-ol) is a neurosteroid positive modulator of GABAA receptors. J Pharmacol Exp Ther. 2006 May;317(2):694-703. [Content Brief]
[2]. Starkenmann C, et al. 5α-Androst-16-en-3α-ol β-D-glucuronide, precursor of 5α-androst-16-en-3α-ol in human sweat. Chem Biodivers. 2013;10(12):2197-2208. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6438 mL | 18.2189 mL | 36.4378 mL | 91.0946 mL |
| 5 mM | 0.7288 mL | 3.6438 mL | 7.2876 mL | 18.2189 mL | |
| 10 mM | 0.3644 mL | 1.8219 mL | 3.6438 mL | 9.1095 mL | |
| 15 mM | 0.2429 mL | 1.2146 mL | 2.4292 mL | 6.0730 mL |
α-Androstenol Related Classifications
HY-W677042 Related Classifications
Powered by Bioz
- α-Androstenol
- 1153-51-1
- 5α-Androst-16-en-3α-ol
- GABA Receptor
- mouse cerebellar granule cells
- seizures
- Staphylococcus warneri DSM 20316
- Propionibacterium acnes ATCC 6919
- Streptococcus agalactiae
- antidepressant-like effects
- HEK 293 cells
- Staphylococcus haemolyticus DSM 20263
- GABAA receptor
- anxiolytic-like effects
- Inhibitor
- inhibitor
- inhibit