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Cat. No.: HY-P5783

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δ-Buthitoxin-Hj2a

δ-Buthitoxin-Hj2a, a scorpion-venom peptide, is a potent NaV1.1 agonist with an EC₅₀ of 32 nM. δ-Buthitoxin-Hj2a can be used for the Dravet syndrome (DS) research.

For research use only. We do not sell to patients.

Formula: C₃₀₄H₄₅₈N₉₀O₉₃S₈
Molecular Weight:7117.96

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

δ-Buthitoxin-Hj2a Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

δ-Buthitoxin-Hj2a, a scorpion-venom peptide, is a potent NaV1.1 agonist with an EC₅₀ of 32 nM. δ-Buthitoxin-Hj2a can be used for the Dravet syndrome (DS) research^[1].

IC₅₀ & Target^[1]

Nav1.1

32 nM (EC₅₀)

All Sodium Channel Isoforms :

Chemical Information

Molecular Weight 7117.96
Formula C₃₀₄H₄₅₈N₉₀O₉₃S₈
Sequence

Gly-Arg-Asp-Ala-Tyr-Ile-Ala-Asp-Asp-Lys-Asn-Cys-Val-Tyr-Thr-Cys-Ala-Lys-Asn-Ser-Tyr-Cys-Asn-Asn-Glu-Cys-Thr-Lys-Asn-Gly-Ala-Glu-Ser-Gly-Tyr-Cys-Gln-Trp-Leu-Gly-Lys-Tyr-Gly-Asn-Gly-Cys-Trp-Cys-Lys-Asn-Leu-Pro-Asp-Lys-Val-Pro-Ile-Arg-Ile-Pro-Gly-Pro-Cys-Arg-NH2 (Disulfide bridge:Cys12-Cys63;Cys16-Cys36;Cys22-Cys46;Cys26-Cys48)
Sequence Shortening

GRDAYIADDKNCVYTCAKNSYCNNECTKNGAESGYCQWLGKYGNGCWCKNLPDKVPIRIPGPCR-NH2 (Disulfide bridge:Cys12-Cys63;Cys16-Cys36;Cys22-Cys46;Cys26-Cys48)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chun Yuen Chow, et al. Venom Peptides with Dual Modulatory Activity on the Voltage-Gated Sodium Channel NaV1.1 Provide Novel Leads for Development of Antiepileptic Drugs. ACS Pharmacol Transl Sci. 2019 Nov 25;3(1):119-134. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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δ-Buthitoxin-Hj2a

All Sodium Channel Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

δ-Buthitoxin-Hj2a Related Classifications

HY-P5783 Related Classifications